喹诺酮类

喹诺酮类Cu（Ⅱ）配合物的电子结构与抗菌活性

Electronic Structures and Antibacterial Activity of Cu (ⅱ) Complexes of Quinolones

结果各类喹诺酮类抗菌药具有不同的Rf值，能较好的进行区别。

RESULTS Different quinolones antibiotics had different Rf .

喹诺酮类N1位定量构效关系研究

Study on the Quantitative Structure-activity Relationship of N_1 Position of Quinolone

目的研究导致大肠埃希菌DNA回旋酶A亚单位的基因变异耐喹诺酮类药物的机制。

OBJECTIVE To study the mutation in DNA gyrase A of Escherichia coli resistante to quinolone antibiotics .

急性感染性腹泻选择首选喹诺酮类，A组87.5%，B组55%，C组72.19%。

Acute infection diarrhea : the percentage of Quinolone was 87.50 % in Group A , 55.00 % in Group B and 71.19 % in Group C.

多黏菌素B单用有很好的抗铜绿假单胞菌效果，与环丙沙星（喹诺酮类）、亚氨培南（β-内酰胺类）联合应用也有明显的联合抗菌效应。

Polymyxin B alone have a good effect against P. aeruginosa , and ciprofloxacin ( fluoroquinolone ), imipenem (β - lactam ) combined have significant antibacterial effects of combined .

目的：探讨喹诺酮类抗生素对重症肌无力（MG）治疗的安全性及其引起肌无力加重反应的可能机制。

Objective : To study the security of fluoroquinolone antibiotics and those underlying mechanisms of the exacerbation of myasthenia gravis ( MG ) following them .

新非核苷喹诺酮类HIV-1逆转录酶抑制剂的CoMFA研究

The CoMFA study on quinolones as novel inhibitors of HIV-1 reverse transeriptase

我院CAP治疗首剂抗生素选择以喹诺酮类抗生素居首位，与指南推荐方案基本符合。

Our hospital CAP treatment of initial antibiotic choice to quinolones ranked first , and guide the recommended scheme is basically consistent with the .

原小檗碱立体结构与四环素类和喹诺酮类结构叠合较好，提示作用机理有相似之处，可能通过抑制细菌核蛋白体30S亚基或DNA回旋酶A产生抑菌作用。

The 3D structures of berberine , tetracyclines and quinolones have been compared and overlapped well , which indicated probably their antibacterial mechanism is identical .

目的探讨人型支原体（Mh）对喹诺酮类药物的耐药机理，指导合理使用抗生素。

Objective To study the resistance of Mycoplasma hominis ( Mh ) to quinolones , and to instruct reasonable application of antibiotics clinically .

方法：在喹诺酮类化合物5与邻苯二胺缩合中，以PPA为脱水剂，可以得到3-脱羧反应的产物。

Methods : By condensing compound 5 with o-phenylenediamine , 3-decarboxylic quinolones can be obtained .

甲氧西林敏感表皮葡萄球菌（MSSE）对头孢菌素类、氨基糖苷类、喹诺酮类依然保持较低的耐药率。

MSSE still kept low resistance to cephalosporins , aminoglycosides and quinolones .

而基础疾病、免疫抑制剂、喹诺酮类药物的应用，与产ESBLs肺炎克雷伯菌和大肠埃希菌感染无统计学意义（P>005）。

Nevertheless basic diseases , using immunosuppressive drugs and using Quinolone did not effect significantly on ESBLs bacteria infection ( P > 0.05 ) .

目的研究伤寒杆菌DNA旋转酶A亚单位基因（gyrA）变异与其耐喹诺酮类的关系。

Objective To study the relationship between the gene mutations of DNA gyrase subunit A ( gyrA ) and quinolone resistance in Salmonella typhi .

在产ESBLs的情况下，细菌的外膜蛋白表达变化不是引起KPn对喹诺酮类耐药的主要原因。

In the case of producing ESBLs , OMP expression change was not the main resistant mechanism to quinolones . 5 .

喹诺酮类（Quinolones）药物是一类人工合成的人畜共用抗生素类药物，对革兰氏阴性菌和阳性菌、支原体、衣原体等有抗菌作用，常被用于水产养殖中的病害防治。

Quinolones were synthetic antibiotics for people and animals , acting on Gram-positive and Gram-negative bacterias , always used in preventing diseases in aquaculture .

质粒qnr介导的肠杆菌科细菌对喹诺酮类药物耐药机制研究进展

Advances in plasmid-mediated qnr quinolone resistance mechanism of enterobacteria

临床治疗MP感染主要选择抑制或影响蛋白质和核酸合成的药物，如大环内酯类、四环素类、氨基糖苷类、喹诺酮类。

Antibiotics which can affect the protein and nucleic acid synthesis , including macrolide , quinolone , aminoglycosides , and tetracycline , were effective for the therapy for MP infection .

结论：喹诺酮类抗生素加重MG症状的机理可能与药物提高血清AchRab水平，增加肌无力评分和肌肉电活动的衰减，从而加重MG神经肌肉接头间传递功能的障碍有关。

Conclusion : Fluoroquinolone antibiotics can aggravate the symptom of MG in related with the increased level of serum AchRab , the elevated decremental rate of neuromuscular junction and then exacerbated blockade .

DBU在喹诺酮类药物合成中催化消除反应研究

Study on catalytic deacidification of DBU in Quinolones synthesis

目的考察不同的喹诺酮类抗生素在蒸发光散射检测器（ELSD）中的响应因子是否一致，进而评价利用ELSD迅速测定该类药物含量的可行性。

Aim To analyze the response factors of different quinolone antibiotics detected by evaporative light scattering detector ( ELSD ) .

ESBL阳性与ESBL阴性大肠埃希菌相比较其对，喹诺酮类、氨基糖甙类、磺胺类的耐药性差异存在显著性（P<0.05）；

Between the positive strains for ESBL and the negative strains , there were some significant antimicrobial resistance differences ( P < 0.05 );

结论：蒙脱石对常用剂量的喹诺酮类药物有强大的吸附作用，服用上述药物应在服用蒙脱石散之后1～2h。

CONCLUSION The adsorption gastric fluid effects of smecta normal usual dose of quinolone agents is very strong , the drugs should be administered after taking smecta 1 ~ 2 hours later .

发现了在不同pH介质中喹诺酮类药物的荧光波长和荧光强度的变化规律，并对喹诺酮类药物质子化作用及互变异构现象与荧光性质的相关性进行了考察。

Rules of wavelength and intensity of the fluorescence in different pH medium were discovered . The correlation between the protonation , tautomerism and luminescence characteristics of quinolone are studied . It is found that in pH 6-8 or 2-4 there are two luminescence species .

目的：研究新喹诺酮类药物培氟沙星（Pefloxacin，PFLX）的抗生素后效应（PAE）。

Objective : To study on the post - antibiotic effect ( PAE ) of the new fluoquinolone pefloxacin ( PFLX ) .

外排泵为肺炎克雷伯菌对喹诺酮类的一种耐药机制，产ESBLs不会增加KPn的外排泵阳性率。

Efflux pump system is one of resistance mechanisms to quinolones of KPn . Producing ESBLs will not increase the positive rate of efflux pump in KPn . 3 .

结论武汉地区社区内STM对喹诺酮类药物的耐药性严重，其主要机制是喹诺酮类耐药决定区（QRDR）的基因突变，特别是多个位点同时突变导致高水平耐药；

Conclusions The resistance of STM from community acquired infection in WuHan is very severe . The resistance mechanism was associated with mutations of the quinolone resistance-determining regions .

方法根据美国临床实验室标准化委员会标准使用微量肉汤稀释法，检测192株肺炎链球菌对红霉素、克林霉素、青霉素、喹诺酮类抗菌药物的最低抑菌浓度（MIC）。

Pneumoniae . Methods The minimum inhibitory concentration ( MIC ) of erythromycin , clindamycin , penicillin and fluoroquinolones against 192 strains of S.pneumoniae was tested with broth microdilution method according to the guidelines of the National Committee for Clinical Laboratory Standards .

以上β-内酰胺类、氨基糖苷类基因型与耐药表型一致，携带qnr基因的菌株不一定对喹诺酮类抗菌药物耐药。

Genotype phenotype of beta-lactamase and aminoglycoside resistant gene was consistent with drug-resistant phenotype . The strains carried gene qnr were not always resistant to quinolone . 3 .