喹啉酸

目的建立用于测定大鼠血清中喹啉酸含量的气质联用（GasChromatography-massSpectrometry，GC-MS）技术。

Objective To establish a sensitive and accurate gas chromatography-mass spectrometry method for determination of quinolinic acid in rat serum .

方法采用大鼠脑室内微量反复注射喹啉酸（quinolinicacid，QA）造成的学习记忆障碍模型和自然衰老大鼠，测定其学习记忆功能和脑内胆碱能神经系统的变化。

Methods The learning and memory impairment model was established through intraventricular injecting quinolinic acid ( QA ) repeatedly .

方法：采用脑立体定向颅内注射喹啉酸所致阿尔茨海默氏病（Alzheimer′SDisease，AD）大鼠模型的方法。

METHOD : Experimental model of Alzheimer ′ s disease was made with rats induced by intracranial injection of quinolinic Acid .

高效液相色谱法测定SHR尿液中犬尿喹啉酸含量的变化

Measurement of urine kynurenic acid by high-performance liquid chromatography in SHR

喹啉酸所致Huntington病动物模型的建立及行为学和组织病理学研究

Establishment of animal model of Huntington disease by use of quinolinic acid and its ethological and histopathological observation

方法用立体定位技术对海马CA1区微量注射喹啉酸（QA）造成AD模型；Y形迷宫检测大鼠学习记忆水平；

Methods The AD pathological model was made by hippocampal CA 1 lesions due to stereotaxic mini injection of quinolinic acid ( QA ), the rat 's learning and memory were observed by Y maze ;

目的：应用喹啉酸损毁Meynert基底核建立非遗传性阿尔茨海默病大鼠模型。

AIM : To establish rat models of non-hereditary Alzheimer 's disease ( AD ) by dama ging bilateral nucleus basalis of Meynert ( NBM ) with quinolinic acid .

【方法】采用醋酸-伊文思兰模型、二甲苯模型、CMC囊法模型、棉球肉芽肿模型和碳粒廓清法模型，研究喹啉酸剂量0.35mg/10g、0.07mg/10g灌服给予对实验性急性和亚急性炎症的影响。

【 Method 】 Acetic acid-Evans Blue model , dimethylbenzene model , CMC-air chamber model , tampon-granuloma model , and carbon granule clearance model were selected to investigate effect of exogenous quinolinic acid with dosage of 0.35mg/10g and 0.07mg/10g on acute and subacute animal models of inflammation .

新型喹啉酸咪唑乙酯类化合物的合成及活性研究

Studies on the synthesis and antibacterial activity of quinolone analogues

喹啉酸的螺旋神经节神经兴奋毒性研究

Studies on neurotoxic effects of quinolinic acid on spiral ganglion

雌激素对喹啉酸致大鼠纹状体神经元损害的影响

Effects of estrogen on striatal neurons damage in rats induced by quinolinic acid

电针抗氧应激对喹啉酸损毁大鼠海马的保护作用

Anti-oxygen Stress Effect of Electro-acupuncture on the Hippocampus Injury in the Rats by Quinolinic Acid

喹啉酸诱发实验性癫痫作用机制的初步研究

A preliminary study on mechanism of experimental epilepsy induced by icv quinolinic acid in mice

2-甲基-3-喹啉酸乙酯衍生物的合成

Synthesis of 3-Carbethoxy-2-Methyl Quinoline Derivatives

用此法合成喹啉酸，产品总收率74.5%，产品纯度98.2%。

The total yield and purity of quinolinic acid was 74.5 % and 98.2 % , respectively .

高效液相色谱&紫外、荧光双检测器同时测定人尿中犬尿氨酸和犬尿喹啉酸

Simultaneous determination of kynurenine and kynurenic acid in human urine by HPLC with ultraviolet and fluorescence detector

喹啉酸的合成研究

Synthesis of Quinolinic Acid

方法：采用D-半乳糖、喹啉酸致痴呆大鼠模型，使用大鼠Y型电迷宫法，研究药物对大鼠学习记忆的影响；

Methods : Y-electronic maze was used to study the behavior of dementia rats induced by D-galactose and QA .

喹啉酸致脑损伤大鼠中枢与外周胆碱能受体活性的变化

Changes of cholinergic receptor activities in central and peripheral system after quinolinic acid ( QA ) caused cerebral injury in rats

参归煎剂对喹啉酸损毁海马所致痴呆大鼠学习记忆的影响

Effect of Ginseng and Angelica Sinensis Decoction ( GASD ) on Learning and Memory of Dementia Rat with Hippocampal Lesions Induced by Quinolinic Acid

结论：喹啉酸对急性和亚急性炎症具有较好的抗炎作用和一定的免疫抑制作用。

Conclusion : Exogenous quinolinic acid is endowed with quite evident anti-inflammatory effects on either acute or subacute animal models with somewhat immunological inhibition .

结果：槲皮素可明显提高喹啉酸所致痴呆大鼠学习记忆水平；

Results : It is showed that quercetin could improve learning ability and memory dificiency in rats with bilateral hippocampal lesions induced by quinolinic acid .