洛贝林

HPLC法测定盐酸洛贝林注射液中的有关物质

Determination of Related Substances in Lobeline Hydrochloride Injection by RP-HPLC

洛贝林可以增加人结肠癌多药耐药细胞株HCT-8/VCR细胞内的罗丹明123的荧光强度，抑制P-gp的外排。

Lobeline can increase the fluorescence intensity of rhodamine 123 in the cell line of Hct-8 / VCR and inhibit P-gp efflux .

结果：在新生儿继发性呼吸暂停的病因中，呼吸系统疾病占早产儿43%（19／44），足月儿31%（10／32），氨茶碱和洛贝林治疗结果的差异显著（P＜0.05）。

Results : Respiratory diseases account for 43 % of preterm babies ( 19 / 44 ) and 31 % of full term babies ( 10 / 32 ) . The difference in therapeutic effects between aminophylline and lobeline hydrochloride was remarkable ( P < 0.05 ) .

对照组则加用可拉明2.5μg/min和洛贝林20μg/min持续静脉点滴24h，治疗前后均抽动脉血进行血气分析，并记录症状。

Using Coramine 2.5 μ g / min and Lobeline 20 μ g / min by vein drop on the control group for 24 hours . Arterial blood gas analysis and symptom were observed at pretreatment and post-treatment .

洛贝林（Lobeline），是一种哌啶类生物碱，能选择性地兴奋颈动脉体化学感受器，反射地兴奋呼吸中枢，大剂量也能直接兴奋呼吸中枢。

Lobeline is a kind of piperidine alkaloid which can selectively active carotid chemoreceptor , reflectively actives respiratory center , and directly actives respiratory center with large dose .

洛贝林逆转结肠癌细胞株HCT-8/VCR多药耐药的实验研究

Study of the Reversal Effect of Lobelin on Multidrug-resistance of Colon Cancer Cell Lines HCT-8 / VCR

洛贝林逆转人乳腺癌细胞MCF-7/ADM耐药作用及其机制

Reversal effect and mechanism of lobeline on the multidrug-resistance of human breast cancer cells MCF-7 / ADM

盐酸洛贝林（山梗菜碱）黑龙江西部盐碱地甜菜播种期的试验

Experiment of Beet on Sowing Time Cultivated in the Saline and Alkali Land of Western Heilongjiang Province

方法：对83例新生儿继发性呼吸暂停的临床分析及氨茶碱和洛贝林治疗进行比较，用统计学卡方检验。

Methods : Aminophylline and lobeline hydrochloride were used in treatment of 83 newborn babies with intermittent apnea and statistics by tested in Chi square test for comparison .

用非水毛细管电泳成功地分离了洛贝林、托吡卡胺、普萘洛尔、阿替洛尔、环扁桃酯、沙丁胺醇、苯海索、芬氟拉明和异丙嗪等9种手性化合物。

Chiral separation of nine enantiomers , which include lobeline , tropicamide , promethazine , propranolol , atenolol , cyclandelate , salbutamol , fenfluramine and benzhexol , has been for the first time achieved by nonaqueous capillary electrophoresis ( NACE ) .