断裂基因

DNA双链断裂修复基因多态性与乳头状甲状腺癌基因重排的相关性分析

Association Study of the Polymorphism in DNA Double Strand Break Repair Gene and Gene Rearrangement in Papillary Thyroid Carcinoma

辐射可以导致生物组织一系列的后果，诸如DNA断裂、基因突变以及细胞的癌变和死亡等。

The radiation can cause several consequences to biological tissue , such as breaks of DNA , gene mutation , canceration or death of the cells or organs .

低能重离子引起DNA链断裂和诱发基因突变谱的研究

Study on DNA Strand Breaks and Mutation Spectrum Induced by Low-energy Heavy Ions

结论随SO2浓度增加，细胞遗传物质损伤加重，且有明确的剂量-效应关系，表明SO2空气污染物是染色体断裂剂和基因毒性因子。

Conclusion With the increase of concentrations of SO2 , the damage of cytogenetic material became more serious and revealed a more clear dose-effect relationship . It suggested that SO2 was a clastogen and genotoxic agent .

Northern杂交分析和质粒DNA断裂分析检测bcl2基因表达和DNA拓扑异构酶II活性。

Expression of bcl 2 gene and DNA topoisomerase II activity were examined with Northern blot analysis and plasmid DNA breakage analysis , respectively .

而且脆性部位与癌基因断裂点及癌基因座位相关。

Furthermore , chromosomal fragile site is closely correlated with oncogene breakage and oncogene seat .

许多分子能与核酸发生相互作用，破坏其模板作用，使核酸链断裂，进而影响基因调控和表达功能。

Many small molecular can interact with nucleic acid , make it rupture and affect the gene 's function of adjust , control and expression .