尿毒症毒素

AOPP随着慢性肾功能衰竭及氧化应激的进展，在患者的循环和组织中潴留，是一类新的尿毒症毒素。

AOPP rise as novel uremic toxins with the progression of chronic renal failure ( CRF ) and oxidative stress and accumulate in patients ' plasma and tissues .

新的尿毒症毒素结合蛋白-晚期氧化蛋白产物结合蛋白分离成功

Successful isolation of novel uremic toxins binding proteins for advanced oxidation protein products

结论：前稀释高容量联机HF清除较大分子量尿毒症毒素明显优于低通量HD。

Conclusion Pre-dilution high volume on-line hemofiltration are markedly superior to low permeable hemodialysis in the clearance of larger uremic toxin molecules .

目的：探讨尿毒血清对人近端肾小管上皮细胞株（HK-2）增殖及转分化的影响，以期阐明尿毒症毒素在人肾小管-间质纤维化中的作用。

AIM : To explore the effects of uremic serum on proliferation and trans-differentiation of human renal tubular epithelial cells . METHODS : Human renal tubular epithelial cell line ( HK-2 ) was cultured in RPMI-1640 medium .

目的通过观察尿毒症毒素对骨髓红系祖细胞红细胞生成素受体（EPOR）的影响，探讨EPOR抑制在尿毒症肾性贫血发生发展中的作用。

Objective To explore the important role of erythropoietin receptor ( EPOR ) in the mechanisms of renal anemia by observing the inhibitory effect of the uremic toxins on EPOR of clone forming unit erythroid ( CFU E ) of rat bone marrow in vitro .

结论尿毒症毒素通过影响HK-2细胞TGF-β1基因表达和蛋白分泌从而在人肾小管-间质纤维化中起重要作用，而以分子质量大于10000u的尿毒症毒素起主要作用。

Conclusion Human renal tubulointerstitial fibrosis is accelerated significantly by uremic toxin , especially molecular weight 10 000 u uremic toxin , through promoting the gene expression and protein excretion of TGF - β _1 of renal tubular epithelial cells in patients with chronic renal failure .

高通量血液透析清除尿毒症毒素疗效观察

The clearance effect of highly permeable dialysis on toxin in uremia

尿毒症毒素多肽二级结构的测定和预测

Determination and Forecast of Secondary Structure of Uremic Toxic Polypeptide

但两组对小分子尿毒症毒素的清除率差异均无显著性（P>0.05）；

No dominant variation of clearing of mini-molecular uremic toxin in both groups were found ( P > 0.05 ) .

结论无醋酸盐血液透析能避免透析中的头痛症状，并能有效清除尿毒症毒素及改善电解质水平。

Conclusion The acetate-free bicarbonate hemodialysis can avoid hemodialysis related headache , and clear uremic toxins and improve serum electrolyte level .

结论：慢性肾衰竭患者体内蓄积的尿毒症毒素可能通过促进肾小管上皮细胞增殖及转分化从而加速肾小管-间质纤维化进程，导致肾功能进行性恶化。

CONCLUSION : Uremic toxin may accelerate renal tubulointerstitial fibrosis through promoting renal tubular epithelial cell proliferation and trans-differentiation in patients with chronic renal failure .