头孢哌酮

用HPLC法测定头孢曲松钠、头孢噻肟钠、头孢哌酮钠聚合物

Determination of the polymers in ceftriaxone sodium cefotaxime sodium and cefoperazone sodium by HPLC

方法建立HPLC法测定不同厂家的注射用头孢哌酮舒巴坦钠的初始含量、高温加速及引湿后含量，并比较其性状及含量变化的情况。

METHODS The contents of Cefoperazone Sodium and Sulbactam Sodium for Injection was determined by HPLC .

[方法]将注射用头孢哌酮钠-舒巴坦钠分别与上述4种输液进行配伍，在0~6h内测定pH值、微粒变化、细菌内毒素含量及含量变化。

[ Methods ] The pH value , particles , content of bacterial endotoxin , content of injection were measured for 0 ~ 6 h.

ADR发生率最高的是头孢哌酮舒巴坦注射剂；

Cefoperazone Sodium and Sulbactam Sodium injection has the highest incidence rate of ADR .

HPLC法测定配伍后头孢唑林钠、头孢哌酮钠、哌拉西林钠含量的经时变化。

The HPLC was used to measure the ongoing change of content of cefazolin sodium , cefoperazone sodium and piperacillin sodium after compatibility .

目的评价氨苄西林-舒巴坦组（A组）、头孢哌酮组（B组）、左氧氟沙星组（C组）三种方案对治疗社区获得性肺炎药物经济学成本与效果。

OBJECTIVE To evaluate the cost-effectiveness of three therapeutic schemes , ampicillin-sulbactam injection ( A ), cefoperazone injection ( B ) and levofloxacin injection ( C ) in treatment of the community acquired pneumonia infections .

结论从头孢哌酮钠的溶解时间和输液不溶性微粒的情况来看，推荐临床使用C或F。

CONCLUSION It is suggested that C or F might be used better in clinical according to the dissolved time of Cefoperazone Sodium for Injection and the particulate matter in fusion in this experiment .

结果：阿莫西林钠克拉维酸钾组的C/E值最小，头孢哌酮钠舒巴坦钠组的ΔC/ΔE值最低。

Results : The group of amoxicillin / clavulanic was the lowest C / E group . The group of cefoperazone / sulbactam sodium was the lowest △ C / △ E group .

前言：目的：了解头孢哌酮与中药柴芩承气汤配伍治疗急性重症胰腺炎与IL-6、IL-8相关性。

Objective : To explore the relationship between SAP treated with Cefoperazone together with Traditional Chinese Medicine ( TCM ) and IL-6 and IL-8 .

头孢哌酮钠联用乳酸左氧氟沙星可减低血浆TF含量，提高TFPI/TF比值。

The treatment with Cefoperazone sodium and Levofloxacin lactate may inhibit the level of TF , but raise TFPI / TF ratio .

敏感率最高的为多粘菌素B为100%，其他依次减少的头孢哌酮/舒巴坦78.3%，头孢他啶72.8%，亚安培南68.0%，阿米卡星66.9%等。

The sensitivity rate of polymyxin rate was the highest ( 100 % ), the others were Cefoperazone / Sulbactam ( 78.3 % ), Ceftazidime ( 72.8 % ), Imipenem ( 68.0 % ), Amikacin ( 66.9 % ) in turn .

头孢哌酮和哌拉西林与β-内酰胺酶抑制剂复方对产酶E.coli和K.pneumonia的抗菌活性及其后效应的研究

A Study on Antimicrobial Activity and Persistent Effects of Combinations Consisted of β - Lactams and β - Lactamase Inhibitors Against β - Lactamase-producing E.coli and K. pneumonia

结论10mg／0.1mL的头孢哌酮／舒巴坦玻璃体腔注射是一个安全剂量。

Conclusion 10 mg of Celoperazone / Sulbaclam is a safe dosage for rabbit intravitreal injection .

体外抑菌试验表明，特异性IgY浓度在1～20mg/ml之间能抑制肺炎克雷伯杆菌的生长且呈剂量依赖性，但其活性低于阳性对照头孢哌酮。

Specific IgY at concentrations of 1 ~ 20 mg / ml inhibited the growth of K. pneumonia in a dose dependent manner .

在限定日剂量（DDDs）排序中前3位抗微生物药物分别为左氧氟沙星片、头孢哌酮/舒巴坦、左氧氟沙星注射液。

In addition , the three antibacterial drugs ranked in primacy in DDDs were levofloxacin tablet , cefoperazone / sulbactam for injection , levofloxacin injection .

结果在25,37℃条件下，冻干型和溶媒结晶型注射用头孢哌酮钠与5种输液配伍后6h内基本稳定。

RESULTS Freezing dried and crystalline cefoperazone sodium for injection were stable within 6 hours after they coexisted with 5 kinds of injections at 25 ℃ and 37 ℃ .

结果：盐酸川芎嗪注射液与注射用穿琥宁和注射用头孢哌酮钠配伍后产生沉淀，与氨茶碱注射液配伍后pH逐渐下降，与其他25种药物配伍后无显著改变。

Results : The mixture of ligustrazine hydrochloride injection with andrographolide and cefoperazone resulted in precipitation , with aminophylline in significant drop pH , but with other 25 drugs no significant change was found in the aspect , pH , particulate and UV absorbance .

结果显示绿脓杆菌对Ceftazidime和头孢哌酮的耐药菌株分别由10%和28%增至37%和46%。

Results showed resistant strains of Pseudomonas aeruginosa to ceftazidime and cefoperazone have increased from 10 % to 37 % and 28 % to 46 % reespectively ;

头孢哌酮含量测定用流动相的改进以对消实验研究EGCG能否逆转脱氧胞苷（dCdR）的补救作用；

Nullification assay was used to examine whether EGCG nullify the rescue effect of deoxycytidine ( dCdR ) to AraC .

目的：测定头孢哌酮和哌拉西林与克拉维酸、舒巴坦、三唑巴坦3种β内酰胺酶抑制剂的复合制剂的最小抑菌浓度（MIC）、杀菌曲线。

Objective : To measure the minimal inhibitory concentration ( MIC ), time-kill curve of the composite preparation of β - lactams and β - lactamase inhibitors against β - lactamase-producing Gram-negative bacteria in vitro .

目的探讨头孢哌酮钠-磷酸钙骨水泥复合体（C-CPC-C）在生物体内、外的药物释放特性。

Objective To investigate the release characteristics of C-CPC-C in vitro and vivo .

产ESBLs株对亚胺培南均呈敏感，对头孢西丁、头孢哌酮-舒巴坦及哌拉西林-三唑巴坦耐药率较低，对其他抗菌药物的耐药率均较不产ESBLs株高。

All ESBLs producing strains in our study were susceptible to imipenem , and relatively susceptible to cefoxitin , cefoperazone-sulbactam and piperacillin-tazobactam . ESBLs-producers had much higher resistance rates to other antimicrobial agents compared with ESBLs non-producing strains .

目的：根据上海市药品不良反应监测中心提供的药物不良反应（ADR）报表，分析注射用头孢哌酮钠及其复方制剂引起皮肤及其附属器ADR后的药物治疗方案。

Objective : To investigate the medication for adverse drug reaction ( ADR ) of skin and its accessories induced by cefoperazone sodium injection and its compound preparations according to the reports provided by the ADR monitoring ( center ) of Shanghai .

从杀菌曲线分析，绝大多数复合制剂为时间依赖性，而头孢哌酮/克拉维酸（1/1）对产ESBL的肺炎克雷伯菌有浓度依赖趋势。

According to the time-kill curves , most of composite preparations killed the bacteria in a time-dependent manner , but the composite preparations of cefoperazone / clavulanicacid ( 1 / 1 ) killed K.

方法对88例急诊重症感染患者，给予头孢哌酮/舒巴坦治疗，采用静脉滴入方式，每12h给药4.0g，观察其临床疗效及安全性。

Methods A total of 88 emergency patients with severe infections were given cefoperazone / sulbactam 4.0g / 12h , iv drip and the clinical efficacy and safety were observed .

ESBLs阳性株除对亚胺培南、头孢哌酮/舒巴坦高度敏感外，对其它抗生素的耐药性明显高于ESBLs阴性株。AmpC酶阳性株均呈多重耐药，其对多种抗生素的耐药性明显高于AmpC酶阴性株。

ESBL producing strains were susceptible to imipenem and cefoprazone / sulbactam , showing more resistant to other antibiotics than ESBLs negative strains . AmpC enzyme positive strains were multiplex resistant , and more resistant to antibiotics than AmpC enzyme negative strains .

目的研究头孢哌酮（CPZ）及不同配比头孢哌酮/舒巴坦（CPZ/SBT）对临床分离致病菌的体外抗菌活性，为临床提供用药依据。

Objective To study the antibacterial activity in vitro of cefoperazone ( CPZ ) and different ratio of cefoperazone / sulbactam ( CPZ / SBT ) and to supply the clinical doctors with useful information .

头孢哌酮/舒巴坦的杀菌指数最大、T>MIC最长，对大部分胆道感染常见致病菌均可形成MIC90100倍以上的浓度，T>MIC长达5～8h；

Cefoperazone / sulbactam had the largest bactericidal index and the longest T > MIC , and it could form 100 times of concentration than the MIC90 of the common pathogens in bile . Also its T > MIC maintained 5 ~ 8h .

目的：建立快速测定犬血浆中头孢哌酮钠和他唑巴坦钠含量的液相色谱-质谱-质谱（LC-MS-MS）联用方法。

Objective : To develop a rapid and sensitive liquid-chromatography-tandem mass spectrometry ( LC - MS-MS ) method for determination of cefoperazone sodium and tazobactam sodium in dog plasma .

亚胺培南、头孢他啶和头孢哌酮/舒巴坦的耐药率为0，除氨苄西林、羧苄西林和头孢唑林外，其他9种抗生素对非ESBL菌株的耐药率<6%。

The resistant rates of imipenem , ceftazidime and cefoperazone / sulbactam to ESBL strains were null percent . Except ampicillin , carbenicillin and cefazolin , other 9 β lactam antibiotics to ESBL negative strains were less than 6 % .