多黏菌素

一种合成肽增强多黏菌素B中和内毒素的能力

A synthetic peptide enhances the endotoxin-neutralizing capability of polymyxin B

复方多黏菌素B软膏治疗细菌性皮肤病临床实验研究

Clinic Study of Bacterial Infected Skin Diseases Treated by Polymyxin B Plus Ointment

多黏菌素B及其模拟肽与脂多糖类脂A结合的比较研究

Comparative study of binding power of polymyxin B and its simulating peptide to lipopolysaccharides lipoid A

亚胺培南、多黏菌素E是治疗鲍氏不动杆菌感染最有效的抗生素。

Imipenem and polymyxin E are the most effective antibiotics for Acinetobacter baumannii .

多黏菌素B对内毒素诱导大鼠肺泡巨噬细胞I-κB激酶mRNA表达的影响

Effects of polymixin B on I - κ B kinase mRNA expression in lipopolysaccharide-induced pulmonary alveolar macrophages

其次是多黏菌素E和美罗培南，敏感率分别>88.0%和84.0%；

The susceptibility rate to polymyxin E and meropenem were more than 88.0 % and 84.0 % , respectively .

目的评价复方多黏菌素B软膏与环丙沙星软膏治疗细菌性皮肤病1周的疗效和安全性。

Objective To assess the effect and safety of polymyxin B plus ointment versus ciprofloxacin ointment in 1-week treatment on bacterial infected skin diseases .

目的：探讨多黏菌素B对多重耐药铜绿假单胞菌（PAE）的体外作用。

Objective : To explore the effect of polymyxin B against multi-resistant pseudomonas aeruginosa ( PAE ) .

多黏菌素B单用有很好的抗铜绿假单胞菌效果，与环丙沙星（喹诺酮类）、亚氨培南（β-内酰胺类）联合应用也有明显的联合抗菌效应。

Polymyxin B alone have a good effect against P. aeruginosa , and ciprofloxacin ( fluoroquinolone ), imipenem (β - lactam ) combined have significant antibacterial effects of combined .

对亚胺培南、美罗培南、多黏菌素B、多黏菌素E的耐药性较低，分别为22.4%、22.4%、0%、10.2%。

The resistant rates of imipenem , meropenem , polymycin B and polymycin E were 22.4 % , 22.4 % , 0 % and 10.2 % separately .

其中耐药率最高的是多黏菌素B，达65.2%；诺氟沙星、头孢噻肟、磷霉素、林可霉素和呋喃妥因的耐药率也较高，均在30.0%以上。

The resistance rate of Polymyxin B is highest , up to 65.2 % . The resistance rate of Norfloxacin Cefotaxime , Fosfomycin , Lincomycin , and Nitrofurantoin is more than 30.0 % .

应用生物传感器及FASTfit作图，比较MP-1、多黏菌素（PMB）与LPS的亲和力，以Kd值表示。

In vitro , the affinity of MP-1 and PMB to LPS was compared by biosensor and FAST fit construct and expressed as Kd .

方法：在内毒素刺激人THP-1细胞分泌细胞因子TNF-α模型上，观察合成肽、多黏菌素B、合成肽和多黏菌素B对内毒素激活THP-1细胞的影响。

METHODS : By model of LPS-induced TNF - α secretion in human THP-1 cells , the affects of anti-endotoxin capability of the peptide , polymyxin B , and the peptide plus polymyxin B were examined .

目的：观察多黏菌素B（PMB）对内毒素（LPS）刺激大鼠肺泡巨噬细胞（PAM）中核因子κB（NFκB）激活通路的影响，并探讨PMB可能的抗炎效应。

AIM : To observe effects of polymyxin B ( PMB ) on LPS induced activation of NF κ B of pulmonary alveolar macrophages ( PAMs ) and explore the possible anti inflammation efficiency of PMB . METHODS : Rat PAMs were isolated and cultured .

结果表明，给鸡饮服多黏菌素后，低剂量组鸡于8d后血浆SOD活性明显升高（P<0.05），MDA含量显著降低（P<0.05），且保持较低的水平；

SOD activity increased significantly and MDA decreased significantly in the low dose group on day 8 after chickens being taken orally polymyxin B in comparison with that in the control group , then MDA kept the low level in the group .

治疗多重耐药革兰氏阴性菌感染的有效抗菌药&多黏菌素

Polymyxin : a Polypeptide Antibacterial Applied to Multidrug-resistant Gram-negative Bacterial Infection

增效硫酸多黏菌素口服液治疗仔猪黄白痢临床试验

Clinical trials of efficiency sulfuric acid colistin oral on controlling yellow and white scour of piglet

药物敏感性实验显示，外科病房医院感染病原菌对亚胺培南、美罗培南和多黏菌素抗菌药物敏感性较好（98%），但产β内酰胺酶的菌株较多，对其他常规抗生素耐药性严重。

The results of antibiotic susceptibility tests showed that pathogens from nosocomial infection in surgery ward were sensitive to such antibiotics as imipenem , meropenem and polymyxin ( 98 % ), but , ESBLs-producing strains were seen more and their drug-resistance to the other common antibiotics were very severe .

对多药耐药和泛耐药菌株，为减少用药量和毒副作用，提高抗菌效果，可考虑多黏菌素B与这些抗生素联合用药。

Multi-drug resistance and pan-resistant strains , in order to reduce the dosage and side effects , improve the antibacterial effect of polymyxin B which could be considered with the combination of these antibiotics . 2 .