头孢噻肟

双纸片协同法用头孢噻肟检测此20株全部为ESBLs阳性，用头孢他啶检出14株ESBLs阳性。

All of the 20 strains were ESBLs positive by double disc synergy test with cefotaxime , but only 14 were the ESBLs positive with ceftazidime .

目的对比观察头孢噻肟（CTX）与其他两种抗菌药物治疗方案对30例血液病合并感染患者杀菌活性（SBA）及临床疗效。

Aim The serum bactericidal action ( SBA ) of cefotaxime and its clinical effect were observed and compared with two schedules of antimicrobial chemotherapy in patients with hematopathy complicated by infection .

HPLC法测定注射用头孢噻肟钠/舒巴坦钠的含量

Determination of cefotaxime sodium / sulbactam sodium for injection by HPLC

HPLC测定烧伤患者肾脏透析排出液中头孢噻肟钠的含量

Determination of Sodium cefotaxime in renal dialysate from burn-injured patients by HPLC

HPLC测定注射用头孢噻肟钠他唑巴坦钠的含量及有关物质

Determination of two components and related substances in Cefotaxime sodium and Tazobactam sodium for injection by HPLC

目的：头孢噻肟iv，drip与头孢肟、头孢布烯序贯疗法治疗下呼吸道感染的成本效果分析。

AIM : To evaluate the cost - effectiveness of sequential therapy of cefotaxime plus ceftibuten for lower respiratory tract infection .

在最佳反应条件下（催化剂用量、反应物用量、结晶pH已经优化）头孢噻肟酸的合成摩尔收率超过98%。

Under the optimum conditions ( catalyst amount used , reactant amount used , crystal pH already optimized ) we got over 98 % yield in cefotaxime acid synthesis .

其中耐药率最高的是多黏菌素B，达65.2%；诺氟沙星、头孢噻肟、磷霉素、林可霉素和呋喃妥因的耐药率也较高，均在30.0%以上。

The resistance rate of Polymyxin B is highest , up to 65.2 % . The resistance rate of Norfloxacin Cefotaxime , Fosfomycin , Lincomycin , and Nitrofurantoin is more than 30.0 % .

结论长程住院、入住ICU等是ESBLs肺炎克雷伯菌医院获得性肺炎发生的危险因素，尤以头孢噻肟的使用是主要危险因素。

Conclusion The reasonable use of cefotaxime is an important measure to control the prevalence of ESBLs-producing strains of Klebsiella pneumoniae .

目的考察注射用头孢噻肟钠在聚氯乙烯（PVC）输液袋、聚丙烯（PP）塑料输液瓶、非聚氯乙烯（NPVC）多层共挤膜输液袋及玻璃瓶包装输液中的稳定性差异。

OBJECTIVE : To observe the stability of cefotaxime sodium for injection in PVC infusion bags , PP plastic infusion bottle , non-PVC multilayer polymer infusion bags and glass bottles .

方法采用现版的不同药典的相关HPLC法及HPLC-MS分析，研究头孢噻肟钠的完全杂质谱。

Methods The current HPLC methods in different pharmacopoeia and HPLC-MS analysis were performed to study on the complete impurity profile of Cefotaxime Sodium .

用头孢噻肟，头孢噻肟/克拉维酸、头孢他啶，头孢他啶/克拉维酸这两对纸片同时进行筛检超广谱β-内酰胺酶，可有效降低ESBLs漏检率。

Using both CTX , CTX / Clavulanic acid and CAZ , CAZ / Clavulanic acid simultaneously can reduce the missing rate of ESBLs .

目的：考察4℃、25℃、37℃下24h内替硝唑葡萄糖注射液与注射用头孢噻肟钠的配伍稳定性。

OBJECTIVE : To evaluate the stability of tinidazole and cefotaxime sodium mixed in infusion fluid at 4 ℃ , 25 ℃ and 37 ℃ for 24 hours .

结论：在4℃6h内、25℃2h内、37℃1h内，替硝唑葡萄糖注射液与注射用头孢噻肟钠的配伍液稳定。

CONCLUSION : Tinidazole and cefotaxime sodium mixed in infusion fluid were stable at 4 ℃ for 6 ℃ hours , 25 for 2 hours and 37 ℃ for 1 hour .

治疗组：静脉注射头孢噻肟钠，每次1.0～2.0g，每8h静注1次，疗程7～14d；

Treatment group : 1.0 ~ 2.0g cefotaxime sodium was given by intravenous injection three times a day for7 ~ 14d ;

方法：186例细菌性肺炎患者随机分为A、B、C组，分别给予头孢噻肟钠、左氧氟沙星、氯唑西林钠治疗，观察各组疗效、不良反应，并运用药物经济学方法进行分析。

METHODS : 186 patients with bacterial pneumonia were selected and randomly divided into 3 groups . Group A were treated with cefotaxime , Group B with levofloxacin and Group C with cloxacillin sodium . The curative effects and adverse drug reactions were observed and analyzed by pharmacoeconomics method .

结论以头孢噻肟，头孢噻肟/克拉维酸这对纸片可达到有效进行CTX-M酶的表型检测的目的；

Conclusions The phenotypic confirmatory tests for CTX-M enzymes can be detected only by CTX and CTX / Clavulanic acid effectively .

CTX-M-1V对第三代含肟基头孢菌素头孢噻肟和头孢噻呋均有较强的亲和力。

CTX-M-1V possessed stronger affinity to third generation cephalosporins containing hydroxyimino - cefotaxime and ceftiofur .

偶数组：B组（传统术后用药组）。A组50例，选用头孢噻肟钠与替硝唑，于手术前30min内单次静脉冲击给药，术中冲洗宫腔、子宫切口及腹腔留置；

Groups A of 50 cases were given tinidazole and cefotaxime sodium in a single intravenous stoss medication in preoperative 30 minutes , douching the uterine cavity and uterine incision during operation , and retaining antibiotics in abdominal cavity postoperatively .

产ESBLs株对亚胺培南敏感率达100%，对哌拉西林/他唑巴坦敏感率为67.74%，对头孢噻肟耐药率为80.65%，对头孢他啶耐药率为19.35%。

MIC results showed that the sensitivity of ESBLs producing strains to imipenem was 100 % . And the susceptibility rate to piperacillin / tazobactam was 67.74 % . The resistance rate to cefotaxime was 80.65 % .

结论：奥硝唑注射液与注射用头孢噻肟钠的配伍液在配伍后4℃8h内、25℃4h内、37℃1h内可使用。

Conclusion : The mixture of ornidazole injection and cefotaxime sodium for injection can be used after ( storing ) at 4 ℃ for 8 h , 25 ℃ for 4 h and 37 ℃ for 1 h.

目的观察成人肝细胞微粒体乙基吗啡N-脱甲基酶（EDM）的活性水平、酶动力学特征及乙醇和头孢噻肟对酶动力学的影响。

Objective To observe the activity level and kinetics characteristic of adults liver mi - crosome ethylmorphine N-demethylase ( EDM ), and to evaluate the effects of ethanol and cefotaxime on the activities and kinetics parameters ( Km and Vm ) of EDM .

进行竞争性结合实验，头孢噻肟的主要靶位是PBP3，Mecillinam的主要靶位是PBP2。

Competition experiments showed that mecillinam binds exclusively PBP 2 , the first target of cefotaxime is PBP 3 . This is a rapid , simple and economic method .

头孢噻肟和他唑巴坦（5∶1,7∶1）治疗作用与头孢噻肟单剂相比无明显差异，ED50比较P>0.05。

The ED 50 of cefotaxime and tazobactam ( 5 ∶ 1,7 ∶ 1 ) on intraperitoneal infections showed no significant difference with that of cefotaxime alone ( P > 0.05 ) .

单次给药中剂量组10h头孢噻肟钠和他唑巴坦钠累计尿排率为49.6±0.58%和80.0±7.0%。

The cumulative urinary excretion rates of cefotaxime sodium and tazobactam sodium were ( 49.6 ± 0.58 ) % and ( 80.0 ± 7.0 ) % after intravenous drip of a single 2.4 g dose , respectively .

采用二倍琼脂稀释法测定头孢噻肟、头孢他啶等十二种抗菌药物对所有菌株的最低抑菌浓度（MIC），统计MIC范围、MIC50、MIC90、耐药率（R%）、敏感率（S%）。

MIC ( minimal inhibitory concentration ) of 12 kinds of antibacterial drugs were detected with double agar dilution method , and statisticed the MIC range , MIC 50 , MIC 90 , resistance rate , susceptibility rate .

头孢噻肟和他唑巴坦（1∶1,3∶1）合剂对金黄色葡萄球菌产酶耐药菌腹腔感染小鼠的治疗作用明显优于头孢噻肟单剂，ED50比较P<0.01。

The therapeutic effect of cefotaxime and tazobactam ( 1 ∶ 1,3 ∶ 1 ) on intraperitoneal infections induced by β - lactamases-producing S.aureus was better than that of cefotaxime alone ( P < 0.01 ) .

结果注射用头孢噻肟钠在各温度条件下于4种包装输液中各检测项目均无明显变化，4组间比较无显著性差异（P0.1）。

RESULTS : No significant change was noted in the detection results of all the items of cefotaxime sodium for injection in 4 kinds of infusion packages and under different temperatures ;

目的：研究头孢呋辛（CXM）、头孢噻肟（CTX）、头孢哌酮（CPZ）、头孢地嗪（CDZM）的抗生素后效应及药物浓度、接触时间、菌种等因素的影响。

AIM : To study the postantibiotic effect ( PAE ) of cefuroxime ( CXM ), cefo-taxime ( CTX ), cefoperazone ( CPZ ), and cefodizime ( CDZM ) and influence of the drug concentrations , exposure time , bacterial species to PAE were studied .

舒巴坦/头孢哌酮与头孢噻肟随机对照多中心临床研究

Multicenter randomized controlled clinical trial on sulbactam / cefoperazone versus cefotaxime