吸收促进剂
- 网络absorption enhancer;permeation enhancer;sorbefacient
![吸收促进剂](../cache/1537528.jpg)
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聚乙二醇1000维生素E琥珀酸酯(TPGS)是维生素E的水溶性衍生物,在国外现已广泛应用于制剂研究中,作为增溶剂、吸收促进剂、乳化剂、增塑剂以及脂溶性药物传递系统的载体。
Alpha-tocopherol polyethylene glycol 1000 succinate ( TPGS ), a water-soluble derivative of natural-source vitamin E , has been extensively applied at abroad as a pharmaceutical excipient , such as solubilizing agent , absorption enhancer , emulsifier , plasticizer and vehicle for controlled drug delivery application .
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复合吸收促进剂对葛根素肠吸收及毒性的影响
Effect of multi-combination absorption enhancer on puerarin intestinal absorption and its toxicity
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方法:在正常大鼠小肠分别给予含与不含吸收促进剂DOC的INSPLANP后,观察降血糖效果。
METHODS : After Ins-PLA-NP that contained or did not contain DOC was administered to small intestine of normal rats , the hypoglycemic effect was observed .
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结论:CGRP可以用于鼻腔给药,其吸收促进剂初步确定为4%MDβCD。
Conclusion : CGRP can be used as a drug for the nasal absorption . 4 % MD β CD wes initially defined as accelerating absorption agent of nasal absorption preparation for CGRP .
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Caco-2细胞转运试验结果显示:与对照组相比,六种吸收促进剂均可显著增加胶原酶的转运效率(P0.05),但促吸收效果依吸收促进剂的不同而有所差别。
The results of transport assay on Caco-2 cells demonstrated that compared with the control group , the absorption enhancers all significantly increased the absorption of collagenase ( P0.05 ), although the promotion degrees were various .
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Unigene的片剂使用肠道大衣,蛋白酶抑制剂和吸收促进剂,以口头提供的多肽和蛋白质。
Unigene 's tablet formulations use an enteric coat , protease inhibitors , and absorption enhancers to deliver peptides and proteins orally .
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采用Carbopol940作为凝胶基质,Azone和丙二醇为透皮吸收促进剂,用均匀实验设计,以芍药苷和绿原酸的累积释放百分率为指标,优选处方基质及透皮吸收促进剂的配比。
Carbopol 940 was used as the gel matrix , Azone and propylene glycol as penetration enhancer . With the Uniform design , regarding the cumulative release amount of Paeoniflorin and Chlorogenic acid as index , the optimise prescription matrices was selected .
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透皮吸收促进剂应用及研究的新进展
New Development of Application and Research of Transdermal Penetration Enhancers
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中药透皮吸收促进剂的研究与发展
Research and development of penetration enhancer of Chinese materia medica
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5种吸收促进剂对胰岛素肠道吸收的影响
Effects of five absorption enhancers on intestinal absorption of insulin
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7种吸收促进剂的鼻黏膜毒性及评价方法
Influence of seven absorption enhancers on nasal mucosa & assessment of toxicity
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几种吸收促进剂和酶抑制剂对胰岛素结肠吸收的影响
Effects of Absorption Enhancers and Protease Inhibitors on Colonic Delivery of Insulin
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柠檬酸和牛胆酸钠作为吸收促进剂将血清内干扰素浓度提高了30~50倍。
The serum concentration increased by about 30-50 times with the absorption promoters .
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肽类药物的口服吸收促进剂氯化N-三甲基壳聚糖
Recent Development of N-trimethyl Chitosan Chloride as an Absorption Enhancer of Oral Peptide Drugs
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不同吸收促进剂对大鼠口腔胰岛素吸收作用的影响
Effects of the various absorption enhancers on the buccal absorption of insulin in rats
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我院2003~2005年钙制剂及钙吸收促进剂利用分析
Utilization of Calcium Products and Calcium Absorption Enhancers
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复合型透皮吸收促进剂对黄芩苷透皮吸收的影响
Study on the effects of compound transdermal enhancers on the transdermal kinetics of baicalin
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目的:介绍桉叶油透皮吸收促进剂研究进展。
OBJECTIVE : Introduce the development of the eucalyptus oil as a transdermal absorption enhancer .
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透皮吸收促进剂对大黄中蒽醌类有效成分透皮吸收的影响
Effects of Skin Penetration Enhancers on the Transdermal Absorption of Effective Components in Anthraquinones from Rhubard
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丁卡因、利多卡因联合透皮吸收促进剂对静脉留置针穿刺镇痛的临床研究
Clinical study of venous indwelling needle analgesia by Tetracaine , Lidocaine combined with Transdermal absorption enhancers
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肠吸收促进剂可改善肠粘膜透过能力低药物的口服生物利用度。
Intestinal absorption enhancers are used to improve oral bioavailability of those compounds with poor membrane permeability .
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肠吸收促进剂的研究进展
Development of Intestinal Absorption Enhancers
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目的:研究复合型透皮吸收促进剂对黄芩苷体外渗透动力学的影响。
OBJECTIVE To study the effect of penetration enhancers on the permeability of papaverine gel through skin .
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目的:对降钙素基因相关肽鼻腔给药制剂的吸收促进剂进行初选。
Objective : Primarily to select absorption accelerating agent of nasal absorption preparation for calcitonin gene related peptide .
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吸收促进剂对鼻腔黏膜毒性影响:1%去氧胆酸钠、1%氮酮和1%甘草酸二钾毒性大;
1 % sodium deoxycholate , 1 % azone and 1 % dipotassium glycyrrhizinate had serious nasal toxicity ;
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综述了近年来肠道、皮肤、鼻腔、眼、呼吸道、直肠等制剂中的药物吸收促进剂毒性的研究概况。
Effects of absorption promoter on drug permeability in one-way slow release of compound tinidazol from the drug film ;
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目的:研究不同的吸收促进剂及酶抑制剂对胰岛素透过口腔黏膜的影响。
To study the effects of various absorption enhancers and enzyme inhibitors on insulin permeation in vitro and in vivo .
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方法用0.5%去氧胆酸钠作吸收促进剂的鼻喷胰岛素治疗8例Ⅱ型糖尿病病人。
Methods Intranasal spray insulin containing 0.5 % sodium deoxycholate as an absorptive promoter was used in 8 NIDDM patients .
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本文综述了肠吸收促进剂研究的实验方法、制剂及生理因素对其促吸收作用的影响、安全性问题以及近年重点研究的促进剂类型。
The experiments , formulation , physiologic variables and toxicity problem are reviewed to exemplify the use of several absorption enhancers .
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结论:初步确定降钙素基因相关肽鼻腔给药的吸收促进剂为4%二甲倍他环糊精。
Conclusion : 4 % MD β CD was initially defined as accelerating absorption agent of nasal absorption preparation for CGRP .