双氯芬酸

双氯芬酸钠缓释胶囊在不同pH中释放度的考察实验

Releasing Rate of Diclofenac Sodium Sustained - release Capsule in Varied pH

HPLC法测定双氯芬酸钠缓释片的有关物质

Determination of Related Substances in Diclofenac Sodium Sustained Release Tablets by HPLC

HPLC法测定双氯芬酸钾片有关物质的探讨

Determination of Related Substances in Diclofenac Potassium Tablets by HPLC

双氯芬酸钾凝胶含量的HPLC测定

Determination of Diclofenac Potassium Gel by HPLC

双氯芬酸配位的SOD模拟物合成与清除O2~（·-）作用研究

Synthesis and O ~ (· - ) _2 Clean Out Action of Diclofenac Metal Complex

丝裂霉素C联合双氯芬酸钠在LASEK术中的应用

Application of mitomycin-C combining with diclofenac sodium in laser subepithelial keratomileusis

刺激性实验结果表明：本品对免眼结膜的刺激性明显低于双氯芬酸钠（P＜0.01）。

The experiments showed that the stimulation of diclofenac acid lysine to rabbit 's eyes was lower than that of diclofenac sodium ( P < 0.01 ) .

RP-HPLC测定血浆中双氯芬酸钠的研究

A study of determination of diclofenac sodium in serum by RP-HPLC

目的：建立HPLC测定复方双氯芬酸钠注射液中两组分含量的方法。

Objective : To establish a HPLC method for the simultaneous determination of diclofenac sodium and lidocaine hydrocride in injection .

结论兔眼玻璃体注入的双氯芬酸钠大于或／和等于700μg时，对视网膜有毒性作用。

Conclusion There is toxic effect on the cone and rod systems of retina when the diclofenac sodium 's dosage is more than 700 μ g.

HPLC法测定非洛地平缓释片释放度的探讨双氯芬酸钠缓释片体外实时释放的研究

Determination of Release of Felodipine Extended-Release Tablets in Vitro by HPLC Studies on the analysis process for dissolution of diclofenac sodium sustained release tablets

FDA建议，对于长期接受双氯芬酸治疗的患者，医生应定期监测其转氨酶水平。

The FDA is advising physicians to periodically measure transaminase levels in patients receiving long-term therapy with diclofenac .

LC-MS确定双氯芬酸钠含片中的有关物质

LC-MS Identification of Related Substances in Sodium Diclofenac Lozenges

结果：该方法双氯芬酸钠的检测限为4.5×10-4μg；进样的精密度RSD为1.7%。

Results : The detection limit is 4.5 × 10-4 μ g and the relative standard deviation for replicate injection is 1.7 % .

结果当兔眼玻璃体注入的双氯芬酸钠大于或／和等于700μg时，ERG检查发现暗适应和明适应b波波幅明显下降。

Results The b wave amplitudes of light and dark adaptation ERG were significantly reduced when the dosage of diclofenac sodium was more than 700 μ g.

特别是当卡波凝胶中是离子形式的双氯芬酸钠时，其有无促透剂的24h累积透过量之比值只为1.17。

Especially for that of diclofenac sodium as ion pair form in carbopol gel , the enhancement ratio was only 1.17 .

目的考察双氯芬酸钾（DP）双层片的体外释药行为和在家犬体内的药动学特征。

Objective To investigate the in vitro release profile of diclofenac potassium double-layer tablet (ⅰ) and study its pharmacokinetics in dogs .

目的研究双氯芬酸钾（DP）脂质体制剂的制备及体外的经皮吸收特点。

Objective To study the preparation of topical liposomal diclofenac potassium ( DP ) formulation and the percutaneous absorption in vitro .

0.1%双氯芬酸钠眼液能减轻PRK术后的疼痛且无明显毒副作用。

Diclofenac of 0.1 % could alleviate the pain after PRK without obvious side effects .

方法：选择20例轻度或中度癌痛的老年患者，口服双氯芬酸钠缓释胶囊100mg，每晚1次。

Methods : 20 senile patients with light or moderate cancer pain were selected .

双氯芬酸钾HPMC骨架片体外释药影响因素研究

Influence of different factors on the release properties of diclofenac potassium from HPMC matrix tablets in vitro

目的：比较双氯芬酸栓与山莨菪碱（anisodamine）注射液对前列腺切除术后膀胱痉挛的治疗效果。

AIM : To compare the clinical efficacy of diclofenac suppository and injection anisodamine in the treatment of cystospasm post-prostatectomy .

目的建立双氯芬酸胆碱（DAC）高效液相色谱测定方法。

Aim : To establish an HPLC method for the determination of diclofenac acid-choline ( DAC ) in aqueous humor of rabbits .

目的：报道了双氯芬酸钠含片中有关物质的LC-MS的鉴定方法。

Objective : A method was described for the identification of related substances in sodium diclofenac loz - enges with LC-MS.

结果山茶油可有效促进非甾体抗炎药的经皮渗透率（除双氯芬酸钠外），尤其对氟比洛芬，促渗效果最明显（P0.01），其增渗倍数达到3.51；

Results Camellia oil could effectively enhance the permeation of drugs through the excited rat skin especially for flurbiprofen ( P0.01 ) with the R_e value ( 3.51 . )

目的：用小鼠和大鼠对双氯芬酸钾（DK）原粉进行镇痛、抗炎的药效作用及急性毒性评价。

OBJECTIVE : Pharmacodynamics and acute toxicity on diclofenac potassium ( DK ) were studied with mice and rats .

目的制备双氯芬酸钠脉冲控释微丸（DSPRP）并考察体内外释药特性。

Aim To investigate the preparation of diclofenac sodium pulsatile release pellets ( DS PRP ), the release in vitro and the pharmacokinetics of the drug .

双氯芬酸和布洛芬的购入金额以绝对优势占据NSAIDs市场的前两位，但呈下降趋势；

Of which diclofenac and ibuprofen occupied the front two position in the market NSAIDs , but it showed a declining tendency .

Photo-Fenton法降解水中新型污染物双氯芬酸及降解产物的毒性评价

Degradation of the emergent pollutant Diclofenac in water by photo-Fenton and toxicity evaluation of its degradation products

双氯芬酸钠和磷酸可待因的平均回收率及RSD分别为99.85%，0.46%和99.80%，0.50%。

The average recoveries and RSD were 99 85 % , 0 46 % for diclofenac sodium and 99 80 % , 0 50 % codeine phosphate , respectively .