选择性抑制

氯化花椒碱对核内依赖于DNA的RNA聚合酶Ⅰ具有选择性抑制作用。

The nitidine possesses a selective inhibition on DNA-dependent RNA polymerase I in nuclei .

选择性抑制γ-分泌酶的活性是抗AD药物研发中面临的一大挑战。

The selective inhibition of γ - secretase is a challenge in the development of anti-AD drugs .

这些说明选择性抑制TOPⅡα的活性可能来源于中间B环上的酚羟基。

These illustrated that selective inhibition of TOP ⅱα might originate from the middle of the phenolic hydroxyl groups on the B ring .

脉冲Nd∶YAG激光对培养肥厚性瘢痕成纤维细胞胶原合成的选择性抑制作用研究

Selectively inhibitor effects of pulsed Nd ∶ YAG laser on collagen synthesis of cultured fibroblasts of hypertrophic scar

GABA和甘氨酸选择性抑制STR，多巴胺对STR有明显抑制作用。

GABA and glycine selectively suppressed the STR , Dopamine heavily suppressed the STR.

选择性抑制COX-2是预防治疗FAP的有效靶点。

Selective inhibition of COX-2 may be an effective strategy for preventing FAP .

目的：观察重组血管基膜衍生多功能肽（Vascularbasementmembranederivedmultifunctionalpeptide，VBM-DMP）对人肺癌细胞增殖的选择性抑制作用。

Objective To investigate the selective inhibitory effect of recombinant vascular basement membrane derived multifunctional peptide ( VBMDMP ) on proliferation of lung cancer cells .

咪苯嗪酮对TXA2和HHT生成的选择性抑制作用

Selective inhibition of ci-914 on the production of txa_2 and HHT

电针治疗CIA大鼠慢性炎症及对COX-2的选择性抑制作用

Therapeutic Effect of Electroacupuncture on Chronic Inflammation in Collagen-induced Arthritic Rats and Its Selective Inhibitory Action on COX-2

结论一定能量密度（1000J/cm2）脉冲Nd∶YAG激光对体外培养肥厚性瘢痕成纤维细胞胶原合成具有选择性抑制作用。

Conclusion Pulsed Nd : YAG laser at energy density of 1000J / cm 2 can selectively suppress collagen synthesis of cultured fibroblasts in HS .

结论ADHD儿童智力、记忆力、注意力水平低于正常儿童，且具有选择性抑制、语音信息的工作记忆和计划的执行功能缺陷。

ADHD children have deficiency in executive functions , such as selective inhibition , working memory and plan implementation .

酸化水玻璃对萤石－石英型矿石中的SiO2具有很强的选择性抑制作用。

Acidized water glass has selective depressing effect on SiO2 in fluorite-quartz type ore. ( 2 ) C shape ; ( 3 ) D shape .

角叉菜诱导大鼠胸膜炎中环氧酶-2的生成及NS-398对其选择性抑制作用

Selective Cyclooxygenase 2 Inhibitors : A Review INDUCTION OF CYCLOOXYGENASE 2 IN RAT CARRAGEENIN INDUCED PLEURISY AND ITS

最后通过小肠传输实验观察了具有COX-2选择性抑制作用的中药青藤碱对早期移植肠运动功能障碍的疗效。

At last , through intestinal transit test , the functional motility effect of Sinomenine , a Chinese herbal extraction that was believed to have selective COX-2 inhibition , was determined .

小干扰RNA（siRNA）选择性抑制基因表达使基因治疗达到最大的特异性，但是弱小的细胞内导入能力、有限的血液稳定性及非特异的免疫原性阻碍了siRNA基因治疗的发展。

SiRNA selectively inhibiting gene express makes gene therapy achieving maximal specificity . But puny introduction capability into cell , definite blood stability and non-specific immunogenicity hinder siRNA development for gene therapy .

通过选择性抑制对S抗原的迟发型皮肤超敏反应，说明仅有环孢霉素能完全抑制EAU的发生。

Only cyclosporine completely inhibited EAU development with selective suppression of delayed type hypersensitivity skin response to S-antigen .

结果表明TFP选择性抑制胞质内依赖Ca~（2+）/CaM的PDE活性。

Results indicate that TFP selectively inhibits Ca ~ ( 2 + ) / CaM-dependent PDE activity rather than the PDE-binding activity of CaM in drug-treated cells of both types .

上述结果基本证实，CI-914在大鼠中性白细胞和血小板对TXA2合成酶具有选择性抑制作用。

It is suggested that CI-914 might selectively inhibit the activity of TXA_2 synthetase in rat platelets and pleural neutrophils .

结论：塞来昔布通过选择性抑制COX-2有效减少了胃肠道的毒性作用，避免了与COX-1抑制相关的生理效应，具有良好的安全性和耐受性。

Conclusion : Because of selective COX-2 inhibition , celecoxib can effectively reduce the gastroenteric toxicity and avoid the physiologic effection in related to COX-1 inhibition , which have good safety and tolerability .

结果黄芩苷元能选择性抑制人白血病K562细胞生长且呈浓度依赖关系，并能诱导细胞凋亡，细胞增殖被阻滞于S期；

Results Baicalein was shown to significantly inhibit the proliferation of K562 cell in a dose-dependent manner and selectively induce apoptosis of human leukemia K562 cells . Flow cytometric analysis showed that baicalein arrested K562 cells in the S phase .

报道了流感病毒体外诱导狗肾细胞系（MDCK）细胞凋亡的检测结果，对黑色素选择性抑制流感病毒诱导细胞凋亡的可能性进行了探讨，同时与临床上常用的抗病毒药物病毒唑的效果进行比较。

The apoptosis induced by influenza virus in cultured MDCK cells was reported and the selective inhibitory effect of melamin on the apoptosis induced by influenza virus was investigated .

结论Thiotepa滴眼液对各种细胞有明显的生长抑制作用；0.05%Thiotepa滴眼液对各种人癌细胞和正常细胞均有强的细胞毒作用，且对人癌细胞无明显的选择性抑制作用。

Conclusions 0.05 % Thiotepa Eye Drops had markedly cytotoxic effects against human cancer cells and human normal cells , no exhibited selective inhibition .

拟青霉代谢物提取物100mg/kg1次性给药对小鼠脑组织单胺氧化酶A具有一定的选择性抑制作用，拟青霉代谢物提取物给药后4h，对小鼠脑组织单胺氧化酶A的抑制率达到66.7%。

Once administration of 100 mg / kg BCPT had certain inhibition effect on MAO-A in brain tissues of mice , while 4 hours after administration with BCPT , the inhibition ratio of MAO-A was 66.7 % .

[结论]电针对胶原性关节炎大鼠慢性炎症具有良好的抗炎效应，其抗慢性炎症作用途径可能通过对COX-2进行选择性抑制；电针抗炎无胃肠道副反应。

[ Conclusion ] EA has a pronounced anti-inflammatory effect on collagen-induced arthritis , and the pivotal mechanism and also the advantage of its therapeutic result may be due to selective suppression of COX-2 gene activation , without destroying COX-1 activity in stomach .

结论：内毒素休克早期给予rBPI（21）能选择性抑制肝组织iNOS活性并改善局部微循环，其作用机理可能与降低组织GTP－CHI活性及其介导生物喋呤诱生有关。

Conclusions : Early treatment with rBPI_ ( 21 ) can selectively inhibit endotoxin-induced hepatic iNOS activity and improve local microcirculatory perfusion , probably through the down-regulation of GTP-CHI activity and biopterin formation in the liver .

结论：7-硝基吲唑通过选择性抑制中枢nNOS活性增强异丙酚麻醉效能，提示中枢NO／cGMP信号转导途径在异丙酚全麻作用机制中发挥作用。

CONCLUSION : 7-NI can increase the anesthetic action of propofol by selectively inhibition of the activity of central nNOS , indicated that central NO / cGMP signal trans-duction pathway play an important role in the general anesthesia machanism of propofol .

方法采用选择性抑制法使s-AST形成免疫复合物后失去活性，然后测出余下的m-AST。

Methods The s AST with anti s AST forms antigen antibody complex and loss of activity by select inhibition way , then m AST activity was determined .

研究结果表明：①利用游离氨和溶解氧对硝酸菌的选择性抑制，通过高的NH3-N浓度和低的溶解氧浓度，可培养出亚硝酸菌为优势菌的活性污泥。

Experimental results demonstrate ( 1 ) With the selective inhibition of free ammonia and dissolved oxygen on nitrate bacteria , the activated sludge predominated by nitrite bacteria may be obtained when the concentration of NH3-N is high and the concentration of dissolved oxygen is low .

结论：青蒿琥酯能选择性抑制人骨肉瘤细胞株HOS细胞增殖，具体机制可能与其诱导HOS细胞凋亡，阻滞细胞周期G2期有关。

Otherwise , caspase-3 and caspase-9 were activated in a dose dependent manner . Conclusions : ART could selectively inhibit the proliferation of human osteosarcoma cell line HOS . The mechanisms might be related with induction apoptisis of HOS cells and G2 / M cell cycle arrest .

结论：以1000J／cm~2脉冲Nd：YAG激光照射能选择性抑制增生性瘢痕成纤维细胞的胶原合成和Ⅰ型前胶原基因表达。

Conclusion : Pulsed ND : YAG laser at energy density of 1 000J / cm ~ 2 can selectively suppress collagen synthesis and type ⅰ procollagen mRNA level in HS fibroblasts .