尼美舒利

目的HPLC法测定尼美舒利胶囊中的有关物质。

Objective To detect the impurities in nimesulide capsules by RP-HPLC .

尼美舒利对结肠腺癌细胞MMP-2表达的影响

Effects of Nimesulide on Expression of Matrix Metalloproteinase-2 in Human Colonic Cancer Cell Lines

HPLC法测定尼美舒利片和胶囊的含量及溶出度

Dissolution and content determination of nimesulide in nimesulide tablets and nimesulide capsules by HPLC

尼美舒利对结肠癌细胞株PGE2及VEGF表达的影响

Effect of Nimesulide on the Expression of PGE2 and VEGF of Human Colon Cancer Cells

尼美舒利联合5-Fu对胃癌细胞BGC-823的抗癌作用研究

Anticancer action of combined use of Nimesulide and 5-Fluorouracil on BGC-823 strain

尼美舒利对人肺癌A549细胞株增殖和凋亡的影响

Effects of nimesulide on the proliferation and apoptosis of human lung adenocarcinoma cell line A549

尼美舒利治疗汉族人群类风湿关节炎的疗效和不良反应的Meta分析

Meta-analysis on the effectiveness and side reaction of Nimesulide for the treatment of rheumatoid arthritis among Han Nationality

结果舒林酸、尼美舒利可以抑制人胃癌SGC-7901细胞生长并具有浓度、时间依赖性；

Results Tumor cells proliferation was inhibited in dose and time dependent manner .

尼美舒利致突变的Ames试验研究

Study on Mutagenicity of Nimesulide in Ames Test

环氧合酶-2、核因子（-K）B在胃癌、癌前病变中的表达及尼美舒利逆转其表达的实验研究

The significance of the expression of COX-2 and NF - κ B in gastric atypical hyperplasia and gastric cancer and the inhibitory effects of nimesulide on these expressions in human gastric carcinoma cell line SGC-7901

目的比较研究尼美舒利（NIM）和肠溶阿司匹林（ASP）治疗牙科手术后疼痛的疗效和安全性。

Objective The efficacy and safety of nimesulide and aspirin were evaluated in the treatment of patients postoperative dental surgery pain .

尼美舒利对人胃癌SGC-7901细胞PGE2合成及COX-2、VEGF表达的影响

Inhibitory effects of nimesulide on synthesis of PGE_2 and expression of COX-2 and VEGF in human gastric cancer SGC-7901 cells

应用尼美舒利可以上调HT-29细胞E-cadherin表达，而对HCT-116细胞E-cadherin表达无明显作用；

Nimesulide induced an increased expression of E-cadherin in HT-29 cells but not HCT-116 cells .

目的：了解尼美舒利治疗骨关节炎（OA）及类风湿关节炎（RA）的疗效及副作用。

AIM : To study the clinical effects and side effects of nimesulide in treating osteoarthiritis ( OA ) and rheumatoid arthritis ( RA ) .

目的：观察国产尼美舒利对类风湿关节炎（RA）和骨性关节炎（OA）的疗效和安全性。

OBJECTIVE : To test the efficacy and safety of nimesulide in patients with rheumatoid arthritis ( RA ) and osteoarthritis ( OA ) of knee .

尼美舒利抑制了HT-29细胞的MMP-2表达，而对HCT-116细胞MMP-2的表达的抑制作用不明显。

Nimesulide down-regulated the MMP-2 expression in HT-29 cells , whereas the expression in HCT-116 cells remained unchanged .

应用尼美舒利可以减少HT-29细胞的MMP-2酶活性成分表达，而对HCT-116细胞MMP-2成分的表达无明显作用。

Nimesulide reduced the MMP-2 's expression of HT-29 cells , whereas the expression level of HCT-116 cells was unchanged .

[结果]MTT分析结果显示尼美舒利对人结肠癌细胞的生长抑制作用呈现时间-剂量依赖模式，肿瘤细胞周期分布分析提示尼美舒利具有明显促进肿瘤细胞G0／G1期阻滞作用；

Results : Nimesulide inhibited tumor cells proliferation in a time and dose-dependent fashion , and caused cancer cells ' G0 / G1 arrest , the inhibitary effect on HT-29 cells were stronger than on HCT-116 cells .

尼美舒利对食管癌Eca-109细胞增殖及COX-2和P27~（kip1）表达的影响

Effect of nimesulide on proliferation of esophageal carcinoma Eca-109 cell line and on COX-2 、 P27 ~ ( kip1 ) expression

结果：尼美舒利的总有效率为83%，萘普生的总有效率为75%（P＜0.05）。不良反应发生率分别为23%和32%（P＞0.05），以胃肠反应为主。

RESULTS : Both nimesulide and naproxen improved the inflammatory signs and symptoms of patients with to_ tal effective rates 83 % and 75 % respectively ( P 0.05 ) and adverse reaction rates of 23 % and 32 % respectively ( P0.05 ) .

尼美舒利对氯化钴诱导的人胃癌细胞HIF-1a、VEGF表达的抑制作用和机制研究

The Inhibitory Effects and Mechanisms of Nimesulide on the Expression of HIF-1 α and VEGF in Cobalt Chloride Induced Human Gastric Cancer Cells

本研究目的是观察选择性COX-2抑制剂尼美舒利对SGC7901胃腺癌细胞PGE2释放及增殖和凋亡的影响。

At present , influence of selective COX 2 inhibitor on proliferation of human gastric cancer cells and mechanism were not very clear .

选择性COX-2抑制剂尼美舒利对COX-2表达不同的人卵巢癌细胞株移植瘤生长的不同影响

The Different Effects of a Selective COX-2 Inhibitor Nimesulide on the Growth of COX-2-Negative / Postive Human Epithelial Ovarian Cancer ( EOC ) Cell Line Xenograft Tumor in Nude Mice

尼美舒利对脑膜瘤细胞ETS-1及MMP-1表达和对脑膜瘤细胞增殖及凋亡的影响

The Effect of Nimesulide on Proliferation , Apoptosis and Expression of ETS-1 , MMP-1 on Human Primary Cultured Meningioma Cells

MIL-100（Fe）不仅是无毒材料，而且具有良好的生物相容性，因此我们研究了该材料对药物尼美舒利的缓释性能。

The material of MIL-100 ( Fe ) is suitable for the application of drug delivery due to their non-toxicity and good biocompatibility .

目的：本实验采用慢性不可预见性温和应激（Chronicunpredictablemildstress，CUMS）建立大鼠抑郁模型，观察尼美舒利对慢性应激大鼠抑郁行为的影响。

Bjective : Chronic unpredicted mild stress was taken to establish rat depression model . To investigate the effect of nimesulide on the depressive-like behaviors caused by chronic mild unpredictable mild stress ( CUMS ) in rats .

结论舒林酸、尼美舒利可以抑制人胃癌SGC-7901细胞增殖，抑制NF-κB，COX-2的蛋白表达在二者抑制肿瘤机制中可能具有一定作用。

Conclusion The proliferation of SGC-7901 cells was inhibited after treated by sulindac and nimesulide . Suppressing COX-2 , NF - κ B expression may play some roles in the antitumor process of these two drugs .

方法对人胃癌SGC-7901细胞采用细胞培养，MTT法检测不同浓度舒林酸、尼美舒利对人胃癌SGC-7901细胞增殖抑制作用，免疫组化、westernblot方法检测药物对COX-2、NF-κB表达的影响。

Methods SGC-7901 cells were treated by sulindac and nimesulide . The anti-proliferative effect was measured by using MTT assay ; COX-2 and NF - κ B protein expression were examined by immunohistochemical stain and western-blot analysis .

结论尼美舒利可抑制食管癌Eca-109细胞增殖，使细胞周期受阻于G0/G1期并诱导细胞凋亡。

Conclusion Nimesulide can inhibit the proliferation of Eca-109 cells , cause G_0 / G_1 phase cell cycle arrest and induce apoptosis .

采用小鼠制作手术创口模型，然后运用COX-2选择性抑制剂尼美舒利对动物皮肤创口愈合过程进行干预。同时设有对照组及3种不同浓度的实验组。

Form surgical wound model using strain Kunming mouse , and intervene the skin wound healing process using COX-2 selective inhibitor nimesulide with the control group and 3 experimental groups with different concentrations of nimesulide .