包衣片

结肠定位魔芋胶-羟丙甲纤维素包衣片的制备及体外释药研究

Study on preparation of konjac glucomannan-hydroxypropyl methyl cellulose compression coated tablets for colonic delivery and in vitro release

体外药物释放及衣膜溶蚀研究表明，在含酶介质中，魔芋胶包衣片的药物释放及衣膜溶蚀随酶浓度增加而加快（P<0.05），具有结肠定位释放特性；在含0.1g。

Drug released and coating film erosion were accelerated with the increase of enzyme contents ( P < 0.05 ), konjac glucomannan coated tablets was used as colon-specific drug delivery system ;

维生素C缓释包衣片的研究

Study on sustained release coating tablet of vitamin C

HPLC法测定保健食品包衣片中合成色素的研究

Determination of Synthetic Colors in Coating Tablet of a Health Food by HPLC

结果表明：与PVP、PAA均聚物和物理混合物相比，PAA/PVP复合物作为药物载体能使萘普生具有肠溶包衣片的性质；

It shows that , compared with PVP , PAA homopolymers and physical mixtures , the complexes of PVP and PAA as drug carriers make naproxen have the property of enteric-coated pellets .

犬口服后，包衣片在升结肠开始释药，并在结肠内停留6～7h。

The coated tablet starts to release drug in ascending colon and remain in colon for 6 ~ 7 h after taking orally .

由血药浓度－时间图可见，给予片芯的对照组时滞很短，而给予吲哚美辛结肠靶向释放片者时滞在5h左右，可见在动物体内包衣片可以控制药物延时释放。

From the fig of blood drug concentration-time curve , we can find that the time lag is very short in the control group which was given the tablets core .

大鼠连续给药5d后，对结肠部位的大体形态学改变、组织学损伤以及组织髓过氧化物酶（MPO）活性进行评分或测定，评价4-氨基水杨酸（4-ASA）结肠定位包衣片在大鼠体内的药效学。

Several indices including macroscopic change , histological damage , and tissue myeloperoxidase ( MPO ) activity were examined after 5 consecutive oral drug administration to assess pharmacodynamics of the coated tablets .

将包衣片在人工胃液中滞留1h，取出放入人工肠液中3h，包衣膜被部分溶蚀，出现大量孔洞，但无放射性漏出；3.5h后有放射性漏出，表明包衣膜开始破裂释药。

Coated tablet is take out after laid in artificial gastric juice for 1 h and placed in artificial intestinal liquid , partial coating is corroded and appears a great quantity of hole in a utensil at 3 h , and coating starts to burst and release at 3.5 h.

鞣酸小檗碱结肠定位包衣片的制备及体外释放度考察

Preparation and Release in Vitro of Berberine Tannate Colon-specific Coated Tablets

对乙酰氨基苯酚生产技术氨酚曲马多薄膜包衣片的工艺控制及质量研究

Study on Tramadol Hydrochloride / Acetaminophen Film Coated Tablet Process Control and Quality

丁香提取物结肠定位包衣片在家兔体内的药物动力学研究

Study on Pharmacokinetics on Colon-specific Delivery Coated Tablet of Syringa Extract in Rabbit Body

以进口尼莫地平薄膜包衣片为参考，比较国内两厂家的尼莫地平固体分散片溶出度。

To comparatively study dissolution of two kinds of nimodipine solid dispersion tablets with domestic tablets .

双氯芬酸钠乙基纤维素水性分散体包衣片影响药物释放因素的研究

The factor of influencing drug release from diclofenac sodium tablet coated with the ethylcellulose aqueous dispersion

复方利血平薄膜包衣片研究

Studies on Compound Reserpine Tablets

目的考察自制的口服5氨基水杨酸结肠定位释药包衣片在体内的结肠靶向性。

OBJECTIVE To investigate the colon targeting property of the self prepared 5 ASA colon specific coated tablets .

目的提高包衣片的稳定性，同时优化选择包衣的生产工艺条件。

OBJECTIVE To improve the stability of the film coated tablets and optimize the condition of the film coating process .

海藻酸钠的最佳浓度是4%。4-氨基水杨酸钠结肠定位包衣片的制备及释放度测定

Preparation of 4 - Paramisan Sodium Colon - specific Delivery Coated Tablets and the Determination of Its Drug - releasing Rate

结论：采用紫外分光光度法测定对氨基水杨酸钠包衣片的含量，比永停滴定法更为简单、快速。

Conclusion : this new method can be used for the determination content of the enteric coated tablet of sodium p-aminosalicylic acid .

目的：考察影响双氯芬酸钠乙基纤维素水性分散体包衣片体外释药的因素。

OBJECTIVE : To study the factor of influencing drug release from diclofenac sodium ( DS ) tablet coated with ethylcellulose aqueous dispersion .

结论：与非包衣片比较，自制的4-氨基水杨酸口服结肠定位包衣片在治疗大鼠溃疡性结肠炎方面有更好的疗效。

CONCLUSION : The self-made 4-ASA oral colon-specific delivery coated tablet showes higher effect than non-coated tablets to treat ulcerative colitis in rats .

目的制备5氨基水杨酸（5ASA）肠溶包衣片，使药物在结肠释放。

OBJECTIVE To prepare the 5 aminosalicylic acid ( 5 ASA ) enteric time controlled released tablets with site specific drug delivery in colon .

目的：评价自制的4-氨基水杨酸口服结肠定位包衣片在大鼠体内的药效学。

AIM : To examine the pharmacodynamics of a self-developed oral colon-specific delivery coat - ed tablets of 4-aminosalicylic acid ( 4-ASA ) on rats .

目的研制时间依赖型口服结肠定位释药双氯芬酸钠包衣片。

Objective To develop a time dependent colon specific delivery system using the diclofenac sodium as a model drug and ethylcellulose ( EC ) as the coating material .

目的建立盐酸小檗碱体内含量测定方法，并考察盐酸小檗碱生物黏附包衣片体内十二指肠靶向性。

OBJECTIVE To develop a sensitive RP-HPLC method for the determination of berberine chloride in beagle dogs , and to evaluate the duodenal targeting property of coated-bioadhesive tablets ( CBT ) .

结果PVP-K30制成的片有光泽，测定脆碎度后有少许崩边缺角现象，包衣后片表面粗糙；

RESULTS The tablet produced by using polyvinylpyrrolidone was glossy , the edge of the tablet was irregular after measuring fragility , the surface was rough after coating ;

对乙酰氨基酚薄膜包衣异型片的药代动力学及生物利用度研究

Studies on bioavailability and pharmacokinetics of film coating special shaped tablet of acetaminophen

我们对渗透泵型控释制剂的研究，从包衣膜和片芯处方两个方面着手。

Our research in osmotic pump formulations will start from two aspects , the core prescription and the coating film .

结论本文采用的包衣材料使包衣片到达升结肠时开始释放药物，药物释放时间可达10h以上。

Conclusion The coating could protect the drug until the tablets reached the ascending colon , where drug was released slowly for over 10 h.

方法：分别考察稀释剂、崩解剂、黏合剂及包衣对氯沙坦钾片溶出度的影响。

METHODS The effects of diluents , disintegrants , bonding agents and coating process on the dissolution profile of the losartan potassium tablets were studied .