他莫昔芬

结论EAC／ADR细胞膜流动性增加与其对阿霉素的耐药性有着密切关系，他莫昔芬在降低EAC／ADR细胞膜流动性的同时降低细胞对阿霉素的耐药性。

CONCLUSION The elevated membrane fluidity in EAC / ADR cell is correlated with Dox resistance tightly . Tam reduces Dox resistance in EAC / ADR cells while cell membrane fluidity is decreased .

结论他莫昔芬在雌激素受体阳性的人乳腺癌细胞中具有抗氧化活性。

Conclusions TAM has the antioxidant activity in human breast cancer cells .

枸橼酸他莫昔芬联合维生素E治疗痛经52例分析

Analysis on the Effect of Tamoxifen Citrate Combined with Vitamin E to Treat Dysmenorrhea

他莫昔芬和腺病毒转染对瘢痕疙瘩成纤维细胞p53表达及细胞周期影响的实验研究

Effects of the Tamoxifen-Treatment and p53 Adenovirus Transfection on the p53 Expression and Cell Cycle in Keloid Fibroblasts

应用基因芯片（Microarray）和实时监测聚合酶链反应（Real-timePcR）技术检测他莫昔芬和雌二醇对人类乳腺癌细胞基因表达的调控

Identification of Genes Involved in the Action of Tamoxifen and Estrogen in the Human Breast Cancer Cells Using Microarray and Real-time PCR Analysis

他莫昔芬的作用包括改变RNA转录的合成，抑制细胞的增殖，使细胞周期停滞于G1期。

Pharmacological effects of tamoxifen include the alteration of mRNA transcriptional synthesis , decrease of cellular proliferation , ceasing of cell cycle in the G1 phase .

目的观察他莫昔芬对体外培养的人白血病细胞系K562细胞增生抑制及诱导凋亡作用。

Objective To investigate the impact of tamoxifen on proliferation and apoptosis in human leukemia cell lines K562 cells .

绝经期乳腺癌妇女服用他莫昔芬后子宫内膜雌、孕激素受体变化及Ki-67的表达

Effects of Tamoxifen on Expression of Oestrogen Receptors , Progesterone Receptors and Ki-67 in Postmenopausal Endometrium

口服他莫昔芬法建立ICR小鼠子宫腺肌病模型

Establishment of an ICR Mouse Model of Adenomyosis by Oral Administration of Tamoxifen

目的：临床分析他莫昔芬（三苯氧胺，TAM）对眼的毒性。

Objective : To Investigate the ocular toxicity related to tamoxifen therapy to breast cancer .

乳癌他莫昔芬（Tamoxifen）治疗反应和雌激素受体的依赖关系

The dependence of response rate on estrogen receptor status in advanced breast cancer treated with tamoxifen

目的：研究γ-干扰素（γ-IFN）对他莫昔芬（TAM）抗乳腺癌细胞的增强作用。

Objective : To investigate the enhancing effect of γ - interferon on anticancer effect of tamoxifen against breast cancer cells in vitro .

而雌激素和VEGF同时存在时，对HVEC的促增殖作用更加显著，二者存在协同作用；他莫昔芬能抑制这种协同促增殖作用。

Estrogen and VEGF enhance the cell proliferation in a synergistic fashion , which in turn can be inhibited by tamoxifen .

在55例晚期乳癌病人中研究了抗雌激素他莫昔芬（TAM）治疗效果和乳癌雌激素受体（ER）状态的关系。

The objective response to antiestrogen tamoxifen ( TAM ) in advanced breast cancer with respect to its estrogen receptor ( ER ) Status was studied in 55 patients .

SHG-44人胶质瘤细胞的离子通道特性及他莫昔芬抗胶质瘤作用的机制研究

Research on Ion Channel Characteristics and Mechanisms of Glioma Inhibition by Tamoxifen in SHG-44 Glioma Cell Line

目的：探讨他莫昔芬（TAM）对人胰腺癌细胞增殖的影响及其机制。

OBJECTIVE : To study the effect and the mechanism of tamoxifen ( TAM ) on the proliferation of human pancreatic cancer cell lines .

据本实验所得结果提示ERβ表达水平可能影响乳腺癌内分泌治疗效果，其高表达者可能对TAM等药物不敏感甚至可能引起对他莫昔芬治疗抵抗和耐药。

According to our study , obtained results suggested thatER β expression levels could affect the treatment of breast cancer on endocrinetherapy , and its overexpression may lead to tamoxifen resistance .

本试验还采用他莫昔芬（Tamoxifen，Tam）拮抗试验和凋亡检测对OP、NP、BPA的作用机理进行了初步探讨。论文共分二部分。

Also , the paper makes some research on the function mechanism of OP , NP and BPA by tamoxifen ( Tam ) resistant test and apoptosis detection method .

但跟这项新研究同时发表的一篇社论说，那些发现乳房X光检查有利于女性的早期研究，是在如今常规使用的药物大幅降低乳腺癌死亡率之前进行的，这些药物包括他莫昔芬（Tamoxifen）；

But an editorial accompanying the new study said that earlier studies that found mammograms helped women were done before the routine use of drugs like tamoxifen that sharply reduced the breast cancer death rate .

目的评估他莫昔芬（TAM）对绝经后妇女子宫内膜的雌激素样作用与性激素受体的改变是否相关，以及细胞增生核抗原Ki-67在子宫内膜中的表达。

Objective To investigate the effects of tamoxifen ( TAM ) on expression of oestrogen receptors ( ER ), progesterone receptors ( PR ) and Ki-67 antigen in postmenopausal endometrium .

目的：研究Cl-通道抑制剂他莫昔芬（tamoxifen）对G1期和S期鼻咽癌细胞容积激活性电流的抑制效应。

AIM : To investigate the inhibitory effects of Cl-channel blocker , tamoxifen , on volume-activated Cl-currents of nasopharyngeal carcinoma cells ( CNE-2Z cells ) in G1 and S phases .

目的研究他莫昔芬体外降低EAC／ADR细胞对阿霉素耐药性的作用及耐药性与细胞膜流动性的相关性。

AIM To study the effect of tamoxifen ( Turn ) reducing doxorubicin ( Dox ) resistance in EAC / ADR cells in vitro , and the correlation of drug resistance with cell membrane fluidity .

目的：探讨雌二醇（E2）和他莫昔芬（TAM）对淋巴因子激活的杀伤细胞（LAK细胞）杀伤卵巢癌细胞3AO作用的影响。

Objective : To investigate the effect of estradiol ( E 2 ) and tamoxifen ( TAM ) on cytotoxicity of lymphokine activated killer cells ( LAK cell ) to lysis human ovarian tumors .

目的：观察氯通道阻断药5硝基2（3苯丙胺）苯甲酸（NPPB）和他莫昔芬对小鼠心室肌容积敏感性氯通道的影响。

Objectives : To examine the effect of chloride blocker ( NPPB and tamoxifen ) on volume sensitive chloride channels in mouse cardiac ventricular myocytes .

目的：通过不同浓度的他莫昔芬（TAM）对体外培养的MCF-7细胞周期进程的影响，探讨TAM治疗乳腺癌的作用机制。

Objective The effect of different dose of tamoxifen ( TAM ) on the growth of human breast cancer cell line MCF-7 in cell culture in vitro has been observed , indicated that TAM may inhibit the growth process of MCF-7 cell .

方法采用了体外MCF7细胞增殖试验检测了OP的类雌激素活性，并用生长曲线分析、细胞周期分析、他莫昔芬拮抗试验和凋亡检测对其作用机制进行了初步探讨。

Methods The estrogenic activity of OP was detected by cell proliferation test of MCF 7 cells in vitro and the mechanism was preliminarily studied by growth curve analysis , cell cycle analysis , tamoxifen ( Tam ) antagonistic test and apoptosis detection .

其中化合物14和21对子宫的抑制作用与他莫昔芬相当或强于他莫昔芬，值得进一步研究。

Compounds № 14 and 21 are superior antagonists to tamoxifen .

他莫昔芬治疗女性绝经后晚期乳腺癌50例

Tamoxifen therapy in 50 postmenopausal patients with advanced breast cancer

绝经后乳腺癌患者服用他莫昔芬发生子宫内膜息肉危险因素的探讨

Risk factors of endometrial polyps in postmenopausal breast cancer patients treated with tamoxifen

他莫昔芬对小鼠淋巴细胞功能的影响

The effects of tamoxifen on lymphocyte function of mice