他汀类药物

早期应用他汀类药物对急性心肌梗死病人总胆固醇、高敏C反应蛋白及不良事件的影响

Influence of early use of statins on the total cholesterol , hypersensitivity-c reactive protein and adverse event in patients acute myocardial infarction

LDL胆固醇水平较高且无法耐受他汀类药物的的人群。

and people with high levels of LDL who cannot tolerate statins .

从另一方面来看，能够帮助增加微生命的行为有：喝2到3杯咖啡或吃降低胆固醇的他汀类药物（1个微生命），吃水果蔬菜（4个微生命），每天锻炼20分钟（2个微生命）。

On the positive side , behaviors that can add half hours of life expectancy include : drinking 2-3 cups of coffee or taking statins , cholesterol-lowering drugs ( one microlife ) , eating fruits and vegetables ( four microlives ) , and working out 20 minutes per day ( two microlives ) . ( Source : time . com )

他汀类药物相关性肌病的肌肉辅酶Q（10）水平

Muscle coenzyme Q_ ( 10 ) level in statin-related myopathy

他汀类药物治疗、LDL胆固醇、C反应蛋白与冠状动脉疾病的关系

Statin therapy , LDL cholesterol , C-reactive protein , and coronary artery disease

现主要从他汀类药物影响小G蛋白信号通路方面，阐述其抑制心肌细胞肥大的主要机制。

This article reviews the main mechanisms of preventing cardiac myocyte hypertrophy via small GTP-binding proteins pathways .

根据卫生保健研究公司IMSHealth统计，去年他汀类药物在美国市场的销售额累计达到216亿美元。

S.sales of $ 21.6 billion last year , according to health-care research firm IMS Health .

他汀类药物抗心房颤动作用的随机对照试验Meta分析

A Meta-Analysis on Randomized Controlled Trial of Statins to Prevent Atrial Fibrillation

抗血小板剂、ACE抑制剂和他汀类药物联合治疗降低卒中的严重程度和高危组织状态

Antiplatelets , ACE inhibitors , and statins combination reduces stroke severity and tissue at risk

他汀类药物预防心房颤动的Meta分析

The randomized control trials of statins for the prevention of atrial fibrillation : a meta-analysis

处方他汀类药物治疗个体中LDL达标率的种族差异

Racial differences in reaching target low-density lipoprotein goal among individuals treated with prescription statin therapy

国内关于他汀类药物在PCI介入患者的使用与冠状动脉粥样硬化病变进展关系的研究尚不多见。

The are not many studies about the relation of usage of statins on the PCI patients and the progress of coronary atherosclerosis .

结论他汀类药物抗炎机制与抑制炎性因子的渗出、降低CRP含量及消除自由基、抑制脂质过氧化有关。

Conclusion The mechanism of anti-inflammatory action of staitns are related to the reduction of inflammatory agent and CRP and MDA contents .

LDL胆固醇水平下降了40%到65%，即使他们之前一直在服用他汀类药物来控制胆固醇。

LDL cholesterol levels plunge by 40 to 65 percent , even if the starting level was achieved with a statin .

一些人认为，他汀类药物之所以能减少心肌梗死的风险，是因为它不仅降低了LDL水平，而且还减少了炎症。

Some had argued that statins reduced heart attack risk not just by lowering LDL levels but also by reducing inflammation .

科学家们认为，他汀类药物之所以可以降低心血管问题的风险，是因为它们可降低坏胆固醇，既即LDL低密度脂蛋白胆固醇的水平。

Statins reduce cardiovascular risk and scientists believe it is because they decrease low-density lipoprotein , or LDL , the so-called bad cholesterol .

他说，他汀类药物可能会降低这类患者的VTE风险。

Statins may reduce the risk for VTE in this patient population , he said .

但到目前为止，他汀类药物增加HDL-C作用并没有直接表现出任何有益的临床效果。

But to date , increases in HDL-C observed during statin therapy have not been directly linked to any beneficial clinical outcome .

冠心病及其高危人群在他汀类药物的应用应加强并且有很大空间。通过药物开发提高HDL-C水平在防治冠心病事件方面将有很好的前景。

Increasing HDL - C level by medicine development will have a bright future in prevention and cure of coronary heart disease events .

医学在线新闻：他汀类药物治疗可能有助于预防心房颤动（AF）复发，一项对植入起搏器患者的观察性研究显示。

MedWire News : Statin treatment may help to prevent atrial fibrillation ( AF ) recurrence , suggests an observational study of patients implanted with a pacemaker .

目的了解冠心病患者经皮冠状动脉内介入治疗（PCI）围术期心肌损伤标记物的变化，探讨他汀类药物预处理是否能够减弱围术期心肌的急性损伤。

Objective To know the changes of myocardial damage markers during elective percutaneous coronary intervention ( PCI ) and to investigate whether to weaken the changes with simvastatin therapy before PCI .

结果：①随着TC基线增高，两种他汀类药物降低TC的绝对幅度增加，而相对幅度增加不明显；

Results : ① With increases of baseline TC level , the absolute reduction of TC was increased for both statins , while no marked increase of relative reduction was observed ;

他汀类药物对大鼠腹腔巨噬细胞分泌MMP-1及TIMP-1的影响

Experimental Study on the Effect of Statins on Matrix Metalloproteinase-1 ( MMP-1 ) and Matrix Metalloproteinase Tissue Inhibitor-1 ( TIMP-1 ) Secreted by Rat Macrophage

最近的研究发现，他汀类药物对人白血病细胞株HL-60、黑素瘤、纤维瘤、乳腺癌等多种细胞有明显抑制增殖及诱导凋亡的作用。

Recent studies have demonstrated that statins inhibit the cell growth and induce apoptosis in various cancer cells such as HL-60 , melanoma , fibroma , breast cancer .

他汀类药物可能通过调节脑内胆固醇代谢、抑制载脂蛋白E表达、减少β淀粉样蛋白形成、降低卒中风险和增强胆碱能神经元功能等机制起到防治痴呆的作用。

Statins may prevent dementia through several mechanisms , such as regulation of cholesterol metabolism , inhibition of apolipoprotein E expression , inhibition of β - amyloid formation , reduction of stroke risk , and enhancement of cholinergic neuronal function .

他汀类药物通过降低肝脏产生的胆固醇而发挥作用，并且在降低低密度脂蛋白或LDL（所谓的坏胆固醇）方面最为有效。

Statins work by lowering the production of cholesterol by the liver , and are most effective at reducing low-density lipoprotein , or LDL , the so-called bad cholesterol .

他说，“即使考虑到所有能想到的混淆因素，（他汀类药物降低VTE）风险的作用仍很显著”。

" Even including all the confounding factors I could find , the risk reduction was still significant ," he said .

另外更为重要的是，他汀类药物同时还能够适度提高循环中HDL-C的水平。

It can further promote intake and catabolism of LDL-C. What is more important is that statins can moderately increase HDL-C level in circulation at the same time .

对四组临床试验的总结研究显示，他汀类药物治疗所致高密度脂蛋白胆固醇（HDL-C）水平增加可改善冠状动脉粥样硬化。

Increases in high-density lipoprotein cholesterol ( HDL-C ) levels during statin therapy are associated with regression of coronary atherosclerosis , a review of four clinical trials has confirmed .

根据目前RCT研究尚不能确定他汀类药物对COPD患者生存率、死亡率等方面的影响。

However , according the currently RCTs studies , the effects of statins on survival and mortality rate of stable COPD patients cannot be determined . [ Conclusion ] 1 .