移码

错义突变和移码突变占全部突变的73%。

Missense mutation and frame shift mutation accounted for 73 percent of all .

错义和移码突变可能是其失活的主要原因。

Missense mutation and frame shift mutation were possibly the main reason of its mactivation ;

在蛋白N端58位碱基后多一G，造成移码突变。

At the N terminal , there was a frameshift mutation at 58 site .

Bax和TGFβRⅡ基因在肺癌组织中的移码突变

Bax and TGF β R ⅱ frameshift mutations in lung cancer

TGFβRⅡ的（A）10未发现移码突变。

TGF β R ⅱ ( A ) 10 frameshift mutations were not found .

测序结果提示无PCR引起的突变，基因无移码，质粒构建成功。

Sequencing results suggest successful plasmid construction , with no PCR caused mutations or frame shifts . 2 .

一例前列腺癌P53基因第6外显子中的移码突变

A case of prostate cancer with a frame shift mutation in exon 6 of p53 gene

14例肿瘤DNA样品中检出p16基因外显子2的19个点突变和1个移码突变。

In 14 NSCLC tissues , 19 point mutations and a frameshift were detected .

结果：12例瘢痕疙瘩标本中有9例p53基因外显子4,5,6,7出现点突变和移码突变，正常瘢痕标本、正常皮肤标本均未检出突变。

RESULTS : Point and frameshift mutations in the exon 4 - 7 of p53 gene were identified in 9 keloid fibroblast tissues .

Ames试验也说明辐照淀粉不诱发DNA中碱基对的置换型和移码型突变。

Ames test showed that both of the base pair transversion and frameshift mutant in DNA was not induced by irradiated starch .

由此推测，该移码突变可能是导致hd（t）突变体推迟抽穗的原因。

This mutation might be the cause that leaded to delay heading date in hd ( t ) mutant .

1例46，XY女性性反转综合征患者有移码突变和点突变并存。

Both frameshift mutation and point mutation concurred in one patient of 46 , XY female ;

方法用PCR变性聚丙烯酰胺凝胶电泳银染法，检测50例肺癌组织Bax和TGFβRⅡ基因移码突变及微卫星改变。

Methods Frameshift mutations and microsatellite alterations were detected in 50 primary lung cancer tissues by PCR , 8 % denature polyacrylamide gel electrophoresis and silver staining .

目的探讨Bax和TGFβRⅡ基因在肺癌组织中的移码突变及其与微卫星改变的关系。

Objective To explore frameshift mutations in the Bax and TGF β R ⅱ genes and the relationship between frameshift mutations and microsatellite alterations in lung cancer .

该突变为移码突变，导致HPGD基因编码的15-羟基前列腺素脱氢酶发生NAD结合位点的缺失。

This mutation is an frame-shift mutation , and causes the loss of NAD binding site .

进一步DNA测序结果显示插入片段与tsbp编码序列一致，阅读框架完整，并且无移码。

Further DNA sequencing manifested that the insertion element was tsbp sequence with complete reading frame and no frame shift .

但实验结果证明改进后的类PTT法用于检测基因阅读框移码突变确实是一种快速有效的方法。

GST fusion protein expression system combined with protein truncation test ( PTT ) protocol was used to detect gene frame shift mutation .

所有移码突变表现为1～2个碱基的缺失或插入，大多（7/9）发生在简单核苷酸重复序列，特别是单腺苷酸重复序列（A）n（5/9）。

All of frameshift mutations were deletion or insertion of 1 2 bp and most of them ( 7 / 9 ) happened at simple nucleotide repeat sequences , particularly within ( A ) n tracts ( 5 / 9 ) .

他们的实验证明，AD脑部存在由于GA缺失造成移码突变的β淀粉样蛋白前体和泛素－B，并推测这种移码突变是AD病理的重要起始因子。

They proved mutants of β - amyloid precursor protein and ubiquitin-B , caused by GA deletion and subsequent frameshift mutation , existed in AD brain and surmised that transcript mutation was a critical factor for initiating neuropathology in nonfamilial AD.

Lis1基因的这种阅读框移码突变是否与肝癌相关，有待进一步验证。但实验结果证明改进后的类PTT法用于检测基因阅读框移码突变确实是一种快速有效的方法。

This improved PTT assay was proved to be a fast and effective way in detecting gene frame shift mutation .

该插入序列造成GRA1基因移码突变。

The frameshift mutation for GRA1 gene resulted from the insertion of exogenous sequence .

结果：从7个ADPKD家系，11例病人中检测到6种突变，其中无义突变2个，错义突变3个，移码突变1个。

Results : 6 mutations and 2 polymorphisms were identified , including 2 nonsense mutations , 3 missense mutations and 1 deletion mutation .

结果：重质芳烃无移码突变和碱基置换效应，微核试验显示在316～1580mg/kg·bw剂量范围小鼠骨髓嗜多染红细胞微核率显著增加（与阴性对照组比较P<0.01）；

Results : Ames test was negative in all dosage groups . The frequencies of bone marrow micronucleus were increased significantly at the dose of 316 ~ 1 580 mg / kg · bw .

角蛋白14基因发生错义和移码突变导致3例严重的Dowling-Meara型单纯型大疱性表皮松解症

Three severe cases of EBS Dowling-Meara caused by missense and frameshift mutations in the keratin 14 gene

结论多于半数的HNPCC发生APC突变，其突变多发生在编码区单核苷酸重复序列（移码突变）或CpG岛（点突变）上，提示APC基因失活在HNPCC为常见的分子事件；

Conclusion Mutational inactivations of APC gene were detected in more than half of HNPCC patients in this study , indicating that APC mutation is a common molecular event in the tumorigenesis of HNPCC .

经序列分析，CMO基因转录本的异常加工将导致移码后提前终止及翻译起始密码或功能结构域的丢失。

Sequence analysis revealed that abnormally processed transcripts resulted in frame-shifts with premature termination by introducing stop codon , removal of translation initiation codon and deletion of functional domain .

对其cDNA插入片段测序后Blast比对并进行阅读框分析，发现该片段翻译时发生了移码，仅表达出一段32个氨基酸残基的未知小肽段，说明该质粒是假阳性。

The cDNA insert was sequenced and Blast in the Genebank . We analyzed the translation reading frame and found that a frameshift occurred , thus the fragment can only express an unknown 32-amino acid residues peptide . This result indicates that the plasmid is still a false positive .

分析结果表明两株生产菌的purA基因发生了1个碱基缺失，导致阅读框发生移码突变；

A one base deletion is discovered in purA gene from inosine producing strain and guanosine producing strain , which will cause the open reading frame shift mutation .

结果19例病例中有11例（13个突变点）发生APC突变，发生率为58%（11/19），其中移码突变9个，无义突变4个，移码突变占多数（69%）。

Results Eleven cases with thirteen mutations were determined . The frequency of APC mutation was 58 % ( 11 / 19 ) . The exhibiting mutations consisted of 9 frameshift mutations and 4 nonsense ones , indicating the existence of more frameshift mutations ( 69 % ) .

测序显示重组质粒上MHCⅠα链胞外区序列与轻链β2m成熟肽基因的靶序列由一柔性的linker相连，阅读框正确且无移码。

Sequencing result proved that expression reading frame of recombinant plasmid was composed of the expected MHC ⅰ α chain extracellular domains sequence of interest and β 2m mature protein gene target sequence , which linked by a limp linker , and there was no base malposition .