颗粒酶

人颗粒酶B基因的克隆、蛋白纯化及表达分析

Cloning , Purification and Prokaryotic Expression of Human Granzyme B Gene

原发性肝细胞癌、肝硬化组织中颗粒酶B的研究

Investigation of the Granzyme B within Hepatocellular Carcinoma and Cirrhosis Tissues

穿孔素和颗粒酶B在移植排斥中的研究进展

Research Advancement of Perforin and Granzyme B in Graft Rejection

穿孔素及颗粒酶B在肝移植排斥反应中的表达及意义

Perforin aud granzyme B expression in liver allograft rejection

截短型转位肽重组抗体/颗粒酶B基因的构建及表达

Construction and expression of recombinant antibody / granzyme B containing truncated translocating peptide

病毒性心肌炎心肌颗粒酶B表达的实验研究

Expression of granzyme B in myocardium with viral myocarditis

Fas/FasL及颗粒酶B在口腔扁平苔藓中的表达及意义

Expression of Fas / FasL , granzyme B and their significance in oral lichen planus

穿孔素与颗粒酶B在鼻NK/T细胞淋巴瘤诊断中的意义

Significance of the expression of perforin and granzyme B in nasal NK / T cell lymphoma

外周血淋巴细胞穿孔素和颗粒酶B在诊断移植肾急性排斥中的作用

Effect of perforation and granzyme B in peripheral blood lymphocytes during acute rejection in renal transplantation

苏木对大鼠同种异位心脏移植心肌颗粒酶bmRNA表达的影响

Effect of Sappan Wood on Expression of Granzyme B mRNA in Rats of Allogeneic Transplantation

病毒性心肌炎小鼠心肌颗粒酶B的表达及清心胶囊的干预作用

Expression of Granzyme B in Myocardium of Mice with Viral Myocarditis and Intervention Effect of Qingxin Capsule on it

心肌中穿孔素和颗粒酶B基因表达水平与心脏移植急性排斥反应的关系

The relationship between acute rejection after heart transplantation and mRNA expression levels of perforin and granzyme B in rat myocardium

结果建立了可诱导表达人颗粒酶B融合蛋白基因的HeLa细胞系。

Results The HeLa cells inducibly expressing granzyme B fusion protein were obtained .

心理性应激可降低颗粒酶B的mRNA表达，虽然也降低颗粒酶A的mRNA表达，但无显著性差异。

It also decreased the mRNA transcripts of granzymes A , but the decreases were not significant .

穿孔素和颗粒酶B蛋白表达对胰腺移植急性排斥反应早期诊断的研究

The Experimental Research on the Perforin and Granzyme B Expressions to the Early Diagnostic Value of Acute Rejection Response after Pancreatic Transplantation

NK/T细胞淋巴瘤的穿孔素和颗粒酶B表达程度与T、B淋巴瘤比较，差异有显著性（P<001）。

Both the expression in B-cell lymphoma , T-cell lymphoma and NK / T-cell lymphoma was significantly different ( P < 0.01 ) .

人颗粒酶B融合蛋白基因的诱导表达导致HeLa细胞凋亡

Apoptosis in HeLa cells caused by the inducible expression of human granzyme B fusion protein gene

人颗粒酶B融合蛋白对转染的HeLa细胞的作用

The effect of human granzyme B - PE domain ⅱ fusion protein on transfected HeLa cells

在CD56bright和CD56dim亚群中，CD95brightCD8+亚群高表达颗粒酶B和穿孔素。

In CD56 bright and CD56 dim subpopulations , CD95 bright and CD8 + subsets had higher percentage of granzyme B and perforin expression .

颗粒酶B与自身免疫疾病及抗病毒感染密切相关，在恶性肿瘤细胞杀伤方面的应用价值正日益受到关注。

Granzyme B is closely related to autoimmune diseases and anti-virus infection process . It is attracting increasing attention for its application in cancer treatment .

以RT-PCR技术检测鼠脾细胞中杀伤效应介质&穿孔素、颗粒酶A及B的mRNA表达水平。

And using RT-PCR analysis to detect the mRNA transcripts of perforin and granzymes A and B in murine splenocytes .

目的：构建人颗粒酶B基因的可诱导表达载体，并将其在Hela细胞中诱导表达。

AIM : To construct inducible expression vector for human granzyme B gene and express it in Hela cell line .

穿孔素和颗粒酶B基因多态性与幼年特发性关节炎相关性分析含穿孔-多分层混合损伤平面编织层合板自振特性

Association of Perforin and Granzyme B Gene Single Nucleotide Polymorphisms and Juvenile Idiopathic Arthritis Free vibration characteristic of plain woven fabric laminates with multiple delaminations around a central hole

电镜和TUNEL分析表明，颗粒酶B融合蛋白基因的诱导表达使部分细胞呈现凋亡的典型特征。

Electronic microscopy and TUNEL analysis showed that the inducible expression of granzyme B fusion protein gene caused typical features of apoptosis .

TNF-α、TNFRⅠ、Fas、FasL和颗粒酶B在口腔扁平苔藓中的表达及意义

Significance of TNF - α, TNFR ⅰ, Fas , FasL and Granzyme B Expression in Oral Lichen Planus

方法：用PCR法获取人活性型颗粒酶B基因序列，克隆入pIND诱导表达载体中。

METHODS : Human active granzyme B gene was obtained by PCR and cloned into the inducible expression vector pIND .

目的探讨肠道病毒（EVs）持续感染、穿孔素及颗粒酶B在扩张型心肌病（DCM）发病机理中的作用。

Objective To explore the role of enterovirus ( EVs ), perforin and granzyme B in the pathogenesis of dilated cardiomyopathy .

凋亡有三条途径：死亡受体途径、线粒体途径和CTL介导的颗粒酶途径。

There are three pathways to apoptosis : death receptor pathway , the mitochondrial pathway and the CTL-mediated granzyme pathway .

颗粒酶A诱导Caspases非依赖性细胞死亡

Granzyme A Induces a Cell Death Pathway Independently of Caspases Activation

在1型糖尿病中，胰岛β细胞主要通过死亡受体介导的信号转导途径及颗粒酶B途径发生凋亡，而在2型糖尿病中，线粒体途径是胰岛β细胞凋亡的主要信号转导途径。

In type 1 diabetes , signal transduction pathway mediated by death receptor and granzyme B pathway participate in the beta-cell apoptosis , however , the main transduction pathway leading to beta-cell apoptosis in type 2 diabetes is mitochondria pathway .