错配修复系统

幽门螺杆菌与DNA错配修复系统

Relationship between Helicobacter pylori and DNA mismatch repair system

DNA错配修复系统研究进展

Advances of Researches on DNA Mismatch Repair System

DNA错配修复系统基因多态性与大肠癌易感

Polymorphisms of the DNA Mismatch Repair Genes and Susceptibility to Colorectal Cancer

微卫星不稳定性可间接反映DNA错配修复系统功能的缺陷。

Microsatellite instability can thus reflect the deficiency in DNA mismatch repair system to some extend .

DNA错配修复系统可以识别并修复这种错误，对维持微卫星长度稳定相当重要。

DNA mismatch repair system is one of the systems in maintaining the length of Microsatellites loci .

错配修复系统广泛的存在于生物体中，由于这个系统的存在保证了DNA复制过程中的保真度。

Mismatch repair systems exist in a wide range of organisms , due to the existence of this system to ensure that the process of DNA replication fidelity .

DNA错配修复系统不仅通过矫正在DNA重组和复制过程中产生的碱基错配而保持基因组的稳定，而且通过诱导DNA损伤细胞的凋亡而消除由突变细胞生长形成的癌变。

DNA MMR system not only ensures the precision of chromosomal replication and maintains genomic stability by correcting the mismatches during the replication and recombination , but also eliminate cancer cells by promoting apoptosis of cells with severely damaged DNA .

近年来研究发现DNA修复基因突变引起DNA错配修复系统的功能降低或丧失，从而引起遗传物质不稳定，主要表现为微卫星不稳定性（Microsatelliteinstability，MSI），进而导致肿瘤的发生。

For the past few years , some research discovered that genetic mutation of DNA repair gene resulted in functional depression and deprivation of DNA mismatch repair system , which caused instability of genetic material , its main appearance is microsatellite instability ( MSI ) that led to carcinogenesis .

血液系统肿瘤中的人类错配修复系统

Human Mismatch Repair System in Hematologic Malignancies

通常认为，基因突变异常累积会导致一些肿瘤的发生，其中包括错配修复系统缺陷和抑癌基因突变。

It is usually considered that abnormal ac - cumulation of gene mutation result in tumorigenesis , which includes the deletion of mismatch repair genes ( MMR ) and the mutation of tumor suppressor genes .

其中修复DNA复制中发生的碱基错配的系统称为错配修复系统，可避免复制错误的产生与积累。

The system is called mismatch repair system whose function is to repair the mismatch of nucleotide in replication and avoid the accumulation of replication errors .

错配识别蛋白MutS是错配修复系统行使修复功能的第一个蛋白，具有识别并结合错配的能力。

DNA mismatch binding protein MutS , is the first protein which initiate the function of MMR . MutS has the ability to recognize and binding mismatched base pair .

异源双链DNA体外错配修复功能检测模型的构建及弥漫性大B细胞性淋巴瘤中错配修复系统的分析

Construction of Heteroduplex DNA and in Vitro Model of Functional Analysis of Mismatch Repair as Well as Its Application in the Diffuse Large B Cell Lymphoma