转录后调控

目前逆转心脏重构的手段仍较缺乏，之前的研究主要集中在心脏重构发病的神经体液和信号转导通路的翻译后调控，对于转录后调控的机制研究较少。

The methods to reverse cardiac remodeling was still deficiency in nowadays , people in the previous researches always focused on the post-translational regulation of neurohumor and signal transduction pathway in the pathogenesis of cardiac remodeling , while the research of the mechanisms of post-transcriptional control was not so much .

缺氧诱导因子-1（HIF-1）是一种具有转录活性的核蛋白，能与靶基因结合并通过转录和转录后调控，使机体对缺氧、缺血产生适应性反应。

Hypoxia inducible factor 1 ( HIF-1 ), a nuclear protein with transcription activity , can make the body produce adaptive response to hypoxia / ischemia by binding to target gene , transcription and post-transcriptional control .

mRNA降解就是通过控制翻译次数在基因表达的转录后调控阶段发挥重要作用。

The mRNA degradation plays an important role in post-transcriptional regulation of gene expression by controlling the number of translation times .

转录后调控包括mRNA的稳定性，定位和翻译效率，其中mRNA稳定性的调节对于基因表达的调控非常重要。

Post-transcription-al regulation include mRNA stability , location and translation efficiency , and mRNA decay plays a critical role in gene expression regulation .

microRNA介导HAb18G/CD147分子转录后调控及其机制

Post-transcriptional Regulation of HAb18G / CD147 Expression by MicroRNA and Its Molecular Mechanism

真核细胞中，在基因的表达转录后调控的过程中涉及到多种蛋白质的参与，其中最重要的是RNA结合蛋白。

In eukaryotic cells , regulation of gene expression at the post-transcriptional level is mainly achieved by proteins , which containing well defined sequence motifs involved in RNA binding .

RNA结合蛋白（RBPs）是一类参与转录后调控的重要蛋白。

RNA binding proteins ( RBPs ) are the key factors that involve in the post-transcriptional regulation .

我们的研究提供了一个全新的以hnRNPK为枢纽的转录后调控通路，对中枢神经系统轴突的成功再生有重要的指导意义。

Our study therefore provides evidence of a novel post-transcriptional regulatory pathway orchestrated by hnRNP K that is essential for successful CNS axon regeneration .

miRNA通过对大量基因进行转录后调控，对骨髓间充质干细胞的分化方向产生重要的调控作用。

MiRNA regulates the direction of differentiation of bone marrow stem cells by regulate a large amount of genes by a post transcriptional protocol .

p16~（CDKN2A）在大鼠白斑病损发生发展中的转录后调控机制

Posttranscriptional mechanism of p16 ~ ( CDKN2A ) in the experimental rat tongue leukoplakia

研究发现小RNA广泛存在于各种生物中，它们作为转录后调控因子在细菌的碳源代谢、铁代谢、群体感应、应激反应、以及致病过程等过程中发挥重要的调控作用。

It has been shown that sRNAs are widely distributed in all living organisms , acting as post-transcriptional regulators and playing important role in bacterial cellular process including iron metabolism , carbon metabolism , quorum sensing , stress respone and pathogenesis .

miRNAs通过转录后调控靶基因参与各种生物学过程，它对哺乳动物中枢神经系统的发育分化具有重要作用。

MicroRNAs ( miRNAs ) are related to diverse biological processes via post-transcriptional regulation of target mRNAs . miRNAs have important functions in the development of mammalian CNS .

尤其是近年来microRNA对转录后调控作用的日益显现，使得更多在转录后和翻译过程的重要信息需要进一步进行多角度的研究探讨。

Especially in recent years on post-transcriptional regulation of microRNA is increasing apparently and the process of transcription and translation after the important information are needed for further study of multiple perspectives .

真核生物编码的小分子非编码RNA是一类重要的转录后调控因子，包括动植物中普遍存在的microRNA，siRNA，以及在哺乳动物生殖细胞中发现的piRNA等。

Small non-coding RNAs are a group of important regulators involved in post transcription regulation in eukaryotes , including microRNA , siRNA that are widely exist in animal and plant , and piRNA identified from mammalian germ lines .

piRNA是在生殖系细胞中发现的一类小RNA，已有的研究表明piRNA可能参与表观遗传学调控、基因转位抑制、转录后调控等。

PiRNA is a class of small RNA found in germ line cells , previous studies show that the piRNA may be involved in epigenetic regulation , gene translocation inhibition , transcriptional regulation and so on .

基因表达调控因其重要性日益成为生命科学领域的研究重点，其中，转录后调控更是研究的热点之一。

The research on gene express regulation becomes an important aspect in the field of life science , in which post-transcription is an even hotter issue .

我们也发现，RNA表现量与其活性的高低并没有相关性，这表示其中可能牵涉到基因转录后的调控。

The lack of correlation between RNA levels and activities of those enzymes indicate the presence of post-translational control .

MicroRNAs（miRNAs）是一类内源性表达的小分子非编码RNA，能够在转录后水平调控基因的表达，已成为当前研究的热点。

MicroRNAs ( miRNAs ) are a class of endogenous expression of small molecule non-coding RNA which could modulate posttranscriptional gene expression , has become a research hotspot .

RNA干涉（RNAinterference，RNAi）技术作为一项新的生物学技术，能通过基因转录后的调控，抑制特定基因的表达，此方法的优点在于只改变目的基因，而不改变植物本身的遗传背景。

As a new biological technology , RNA interference technology ( RNAi ) can suppress specific gene expression by the regulation of gene transcription . This method has the advantage that only change the target gene without changing the genetic background of the plant itself .

这些实验表明，FFC和外核体是组成转录后负调控反馈环路的组成部分。

Taken together , these results suggest that FFC and the exosome are part of a posttranscriptional negative feedback loop that regulates frq transcript levels and the circadian output pathway .

它主要通过介导靶基因（靶）的裂解或抑制靶的翻译从转录后水平调控靶的表达，在植物的生长、发育、分化、凋亡、新陈代谢、应激反应等方面起着重要的调控作用。

Plant miRNAs can regulate gene expression mainly by degrading targeted mRNAs or repressing gene translation at the post transcriptional level , playing an important regulatory role in controlling plant growth , development , differentiation , apoptosis , metabolism and stress response .

RNA分子生物学研究表明RNA的转录后修饰在调控基因表达方面发挥着重要的作用。

In recent years , research focusing on RNA molecular biology has shown that this post-transcriptional event plays important roles in the overall regulation of gene expression .

转录后基因表达调控在线粒体转录本后期的修饰中起着关键的作用，主要体现在蛋白质的丰度变化比mRNA的丰度高。

Post-transcriptional regulation of gene expression play a key role in mitochondrial transcript modification , and it is mainly reflected in change of the protein abundance is higher than mRNA .

大量研究证明再水化期间Tortularuralis基因表达的改变，主要在转录后水平上调控，从性质上稳定的mRNA库选择和/或编码不同rehydrinmRNAs的结果。

It is suggestive that the alteration in gene expression associated with rehydration is mediated mainly by an alteration in translational controls at the level of differential selection and / or recruitment by translational machinery from a qualitatively constant mRNA pool .

然而它的转录后修饰以及调控机制还没有被研究过。

However , the post-translational modification and regulation of this protein has not been studied yet .

基因沉默的机制是多方面的，包括转基因多拷贝之间的异位配对，转基因序列的甲基化，插入位点在染色体结构上的改变及转录后的衰退调控等。

The mechanisms of gene silencing include the ectopic pairing among multi_copy of genes , methylation on the sequences of genes , structure changing of chromosome on insertional locus , and the declining control of post_transcription .

这些蛋白主要参与转录后水平的各种调控（比如mRNA稳定性或翻译增强/沉默）。

These proteins are involved mainly in various posttranscriptional regulations ( e.g. , mRNA stabilization or translational activation / silencing ) .

RNA结合蛋白是转录后水平基因表达调控的主要承担者。

RNA & binding proteins ( RBPs ), which usually have conserved RNA-binding motifs , are key molecules in posttranscriptional gene expression control .

MicroRNAs（miRNAs）是一类在转录和转录后水平调控基因表达的小RNA分子。

MicroRNAs ( miRNAs ) are noncoding small RNAs which regulate gene expression at transcription and post-transcription level .

miRNAs是一类内源性RNA分子，可以在转录和转录后水平调控基因的表达。

MicroRNAs ( miRNAs ) are a class of small endogenous RNAs that play a regulatory role in cells by negatively affecting gene expression at transcriptional and post-transcriptional levels .