路易氏剂

为证实口服二巯基丁二酸（DMSA）治疗路易氏剂中毒的效价，以狗为实验动物，进行实验治疗研究。

To confirm the antidotal action of dimercaptosuccinic acid ( DMSA ) against lewisite intoxication , a study on experimental therapy in dogs was carried out .

目的：制备抗重度路易氏剂中毒静脉注射用的二巯基丁二酸类抗毒药（DMSA）。

Objective : To prepare antidote of the type of dimercaptosuccinic acid ( DMSA ) for the treatment of animal with heavy lewisite intoxication through intravenous injection .

固相微萃取衍生化与GC-MS测定水中痕量路易氏剂的方法研究

Study on determination of trace amounts of lewisite in water with solid phase micro-extraction direct derivatization and GC-MS

狗口服DMSA40mg／kg可对抗路易氏剂1个致死量中毒，其效价与静脉注射同剂量DMSA（钠盐）相当。

An oral dose of DMSA ( 40 mg / kg ) could antagonize one lethal dose of lewisite intoxication in dogs . Such effectiveness could be compared to the same dose level of DMS Na given intravenously .

建立了固相微萃取（SPME）与气相色谱/脉冲火焰光度检测器（GC/PFPD）联用测定大气和水中路易氏剂及其水解产物的方法。

A novel method for the determination of Lewisite and its hydrolysates in ambient air and water by solid phase microextraction ( SPME ) coupled with gas chromatography and pulsed flame photometric detector ( GC / PFPD ) was developed .

建立了土壤基质中不同浓度的路易氏剂的测定方法，即液液萃取-气相色谱法（LLE-GC）和固相微萃取-气相色谱法（SPME-GC）。

Two methods for the determination of lewisite in soil after derivatization have been developed , namely , liquid-liquid extraction-gas chromatography ( LLE-GC ) and solid_phase micro_extraction-gas chromatography ( SPME-GC ) .

以上结果证明，口服DMSA可以代替静脉注射途径给药对抗路易氏剂中毒，作者推荐的人用剂量为口服每次2g／人，每日2次。

It could promote the arsenic excretion just similar to the intravenous route . These results show that intravenous DMS Na may be replaced by oral DMSA to antagonize the lewisite intoxication . The authors recommend the oral dose of DMSA in human to be 2 g twice daily .

结论：口服胶囊中DMSA粗品经纯化后，可供静脉注射之用，抗动物路易氏剂中毒效果好，为下一步药物制剂研究及临床应用研究提供了实验数据。

Conclusion : DMSA raw material in the oral capsule can be used for intravenous injection after purification , its effectiveness in treating the lewisite intoxication in animal experiments is quite satisfactory . These results will provide some experimental data for the pharmaceutical and clinical researches .

口服巯基解毒剂治疗路易氏剂中毒的疗效

Antidotal Effect of oral administration of two SH-compounds on lewisite intoxication

气相色谱-原子发射光谱法测定水中微量路易氏剂的水解产物

Determination of Micro-amount of Hydrolysate of Lewisite in Polluted Water by Gas Chromatography-Atomic Emission Spectrometry