蛋白质家族

根据E值和训练分数进行蛋白质家族的识别和分类。

By E values and training scores an experiment for recognition and classification of protein family is given .

金属蛋白酶解离素家庭（ADAMs）是锚定于细胞膜的细胞表面蛋白质家族，其成员具有广泛的生物学活性。

ADAMs is a protein family of cell surface anchored-membrane . Whose members have extensive biological activities .

目的：热休克蛋白（Heatshockprotein，HSP）是一个广泛存在却又高度保守的多肽类蛋白质家族，按其分子量大小可分为HSP27、HSP60、HSP70、HSP90等。

Objectives : Heat shock protein ( HSP ) is a ubiquitous highly conserved polypeptide protein family .

热休克蛋白（HSP）是一个成员庞大的多肽类蛋白质家族。

Heat shock protein ( HSP ) is a family of poly-peptdic-proteins with many members .

Caspase是一组与凋亡密切相关的蛋白质家族，参与多种神经疾病的发病机制。

Caspase is a family of cysteine proteases closely associated with apoptosis and is involved in the pathogenesis of many neurologic diseases .

BcL2蛋白质家族&定位与转位

Bcl-2 Protein Family : Localization and Translocation

运用BLAST方法对EST序列进行分析，初步预测该EST序列为光裂合酶／蓝光受体蛋白质家族中一个成员的部分cDNA。

This EST was analyzed by method of BLAST , and the conclusion suggests that the sequence probably be a partial cDNA that can code one of protein family of photolyase / blue light photoreceptor .

目的：解偶联蛋白2（UncouplingProtein2，UCP2）是线粒体内膜解偶联蛋白质家族成员。

Objectives : Uncoupling protein 2 ( UCP2 ) is a member of the anion carrier family localized in the inner mitochondrial membrane .

基质金属蛋白酶（MMPs）是一类能够联合降解细胞外基质的蛋白质家族，目前已发现20多种。

The Matrix metalloproteinases ( MMPs ) are a family of enzymes that collectively degrade the components of the extracellular matrix , and more than 20 kinds of MMPs have been discovered .

Hsp-s是一种高度保守的蛋白质家族，广泛存在于真核生物和原核生物中。

Hsp-s is a highly conserved protein family widespread in eukaryotes and prokaryotes .

热休克蛋白（HSPs，也称为应激蛋白）是一个高度保守的蛋白质家族，广泛分布于现知的所有活体组织内。

Heat shock proteins ( also known as stress proteins ) constitute a family of highly conserved and abundant proteins present in all living organisms investigated thus far .

根据分析结果及已发表文献，讨论了U-box蛋白质家族的结构与功能的关系。

We discuss the relationship between the structure and function of the U-box family proteins based on these results and published information .

Bcl2蛋白质家族的抗凋亡和促凋亡成员，在线粒体水平上决定细胞的存活或死亡。

Bcl 2 protein family members , including anti apoptotic and pro apoptotic members , act on mitochondria controlling the fate of cell between life and death .

Synaptotagmin（Syt）是一个广泛存在于神经和内分泌细胞内的分泌囊泡上的蛋白质家族。

Synaptotagmin ( Syt ) is a large protein family existed on secretory vesicles and granules in neuron , neuroendocrine and endocrine cells .

根据已知的四类蛋白质家族（酶，GPCR，离子通道和核受体）以及与之相互作用的药物数据，提出了一种基于改进的二分图学习方法来预测药物靶标相互作用网络。

An improved bipartite graph learning approach was developed to predict drug-target interaction network for four classes of enzymes , ion channels , G-protein coupled receptors ( GPCR ) and nuclear receptors .

AOX属于双核铁羧基蛋白质家族，由小的核基因所编码。AOX的表达受到多种生物和非生物胁迫所诱导。

The alternative oxidase is a member of the binuclear iron carboxyl proteins family . The alternative oxidase is encoded by a small family of nuclear genes , and expression of AOX genes is induced by diverse biotic and abiotic stress .

转化酶抑制子（INVINH）是高等植物中一类全新的由小基因编码的蛋白质家族，近年来成为在翻译后水平研究植物光合运转糖调控植物产品器官发育和品质的重要因子。

Invertase inhibitor ( INVINH ) is the new proteins encoded by small gene family in higher plants , it play an important role of research on plant photosynthesis functioning sugar organ development and quality of plant products at level of post-translational in recent years .

参与植物膜泡运输的蛋白质家族及功能研究进展

Current Progress on the Protein Families Involved in Plant Vesicular Traffic

利用神经网络对蛋白质家族进行预测

The Application of Artificial Neural Net to Prediction of Protein Family

膜结合鸟苷酸激酶蛋白质家族的结构与功能

Structure and Function of Membrane-associated Guanylate Kinase Family Proteins

为一包含了许多多重序列校准，以及“隐藏式马尔科夫模型”的巨大集合，里面涵盖了许多常见的蛋白质家族。

Pfam is a large collection of multiple sequence alignments and hidden Markov models covering many common protein families .

关于蛋白质家族、结构和新功能的统计推断是应用数理统计的一个前沿交叉研究方向。

The statistical inference for the protein families , structures and new functions is a frontier research field in the applied statistics .

蛋白偶联受体，有超过一千个成员，是人类基因组中最大和最多样性蛋白质家族。

G protein-coupled receptors , with more than one thousand members , is the largest and most diverse protein family in the human genome .

由于自然选择法则的作用，在一个蛋白质家族中与分子功能相关的氨基酸残基在进化过程中呈现保守性特征，蛋白质与外界的作用依赖于这些关键的残基。

Under the works of natural selection , amino acid residues that are involved in the function of a given protein family are more conservative . The interaction between proteins and environments depends on these important residues .

蛋白激酶是最大的、也是最重要的蛋白质家族之一。在真核细胞内，大约有2%的基因编码激酶蛋白，有约30%的蛋白至少有一个位点被磷酸化。

It has been estimated that 30 % of all cellular proteins are phosphorylated on at least one residue in a typical eukaryotic cell . Therefore , protein kinases ( PKs ) are one of the largest protein families , comprising ~ 2 % of all eukaryotic genes .

核受体组成一个蛋白质大家族，它们作为配体调节的转录因子，能够直接与DNA结合，调节下游靶基因的表达。

The nuclear receptors constitute a large family of proteins and can be considered as ligand-inducible transcription factors , which can bind directly to DNA and regulate expression of downstream target genes .

DNA结合抑制蛋白（InhibitorofDNAbinding，Id），属于螺旋-环-螺旋蛋白质超家族，相对分子质量为13000～20000，它是一组缺乏碱性DNA连接结构域的HLH因子。

DNA binding protein ( Inhibitor of DNA binding , Id ), are helix-loop-helix protein super-family , relative molecular mass of 13000 ~ 20000 , which is a group of the lack of basic HLH domain of DNA connecting factor .

进一步对其功能的研究发现，多药转运体是一类ATP结合蛋白质超家族，能够识别多种作用机制不同的抗癫痫药物，能够主动将药物泵出到血脑屏障以外。

To investigate its function find that multi-drug transporters are ATP-binding cassette superfamily , they can accept a wide range of antiepileptic drugs with different mechanisms as their potential substrates , and actively efflux drugs out of the brain .

蛋白质超家族模体保守性及物理化学性质的分析

Analysis of the Conservative and Statistical Features of the Motifs in Protein Superfamilies

全α类蛋白质超家族保守模体特征的分析

Analysis of Conservative Motif Features of the Protein Superfamilies in All α Class