蛋白质药物

口服蛋白质药物AC缓释微球的膜性能研究

Studies on the Membrane Characteristics of Alginate-Chitosan ( AC ) Microspheres for Oral Protein Delivery

复乳法制备蛋白质药物PLGA微球的影响因素

Influence Factors on Preparation of Protein Drugs Loaded PLGA Microspheres by Double Emulsion Method : A Review

TOFMS提供了一种测定蛋白质药物纯度快速准确的新方法。

MALDI / TOF MS can be used as a quick accurate analytical method for the determination of the purities of protein drugs .

复乳法是制备蛋白质药物PLGA微球最常用的方法。

The double emulsion method is the often used technique for preparation of protein drugs loaded PLGA microspheres .

结论PLGANPs可能成为大分子蛋白质药物口服给药的新型载体。

CONCLUSION PLGA NPs might be used as a new oral carrier for protein drug delivery systems in the future .

改善蛋白质药物PELA控释微球释放性能的研究

Study on Improvement of Release Behavior of Protein Drugs from PELA Microspheres

[目的]探索可生物降解乳酸/羟基乙酸共聚物[poly（lactic-co-GlycolicAcid），PLGA]纳米粒（nanoparticle，NP）作为大分子蛋白质药物的载体经鼻黏膜给药的可能性。

[ Objective ] To investigate the possibility of [ poly ( lactic-co-glycolic acid ) , PLGA ] nanoparticles ( NP ) as a new kind of protein drug carrier for nasal administration .

MVLs纯化后将导致大量的未包封蛋白质药物流失，而且分离MVLs本身也是一个比较复杂的过程。

Furthermore , after purification of MVLs , it is likely to make much more unencapsulated protein lost , and purification of MVLs itself is a more complicated process .

冷冻干燥是制备蛋白质药物常用方法。

The method most commonly used for pharmaceutical protein products is lyophilization .

摘要目的制备蛋白质药物非注射给药载体。

Aim to prepare the carries for non-injection administration of protein drugs .

壳聚糖季铵盐纳米粒子的制备、表征及其缓释蛋白质药物性能

Preparation and Controlled Release of Quaternized Chitosan Nanoparticles as a Protein Carrier

生物降解多肽和蛋白质药物的控制释放研究

Studies on controlled delivery for peptide-protein drug with biodegradability

动物细胞表达的基因重组蛋白质药物

Gene recombinant protein drug produced by animal cell line

蛋白质药物长效化技术的现状和进展

Current Status and Progress on the Techniques for Prolonging Half-life of Protein Pharmaceuticals

结果与结论多肽、蛋白质药物缓释微球在药学领域有着广阔的发展前景。

Results and Conclusions Polypeptide-protein microspheres have broad prospects in the pharmaceutical filed .

蛋白质药物新剂型的研究和进展

The development of new dosage forms of protein drugs

可生物降解聚合物微球化蛋白质药物的稳定性研究

Research on stability of proteins in biodegradable microspheres

蛋白质药物的入脑转运

Delivery of protein - drugs into brain

治疗脑内疾病的有效途径是用载体向脑内运送蛋白质药物（如抗体、神经营养因子、生物活性酶等）。

Delivery of protein-drugs into brain is an effective way for treating diseases in brain .

合理的分子设计与工程化蛋白质药物

Rational Design and Engineering of Therapeutic Proteins

蛋白质药物的海藻酸钙/壳聚糖微球控释载体制备及性能研究

Preparation of Calcium Alginate / Chitosan Microsphere for Protein Oral Delivery and Its Properties Study

迅速发展中的生物质谱仪及相关高新技术为蛋白质药物代谢产物结构分析与蛋白质药物的体内代谢途径研究奠定了基础。

Bio-Mass Spectrometry in Progress and Related Technology protein drugs were analyzed and identified by bio-mass spectrometry .

多肽、蛋白质药物缓释微球研究进展

Research development on Polypeptide-Protein microspheres

蛋白质药物在高聚物基质中的扩散行为

Proteins diffusion in polymer matrices

亲和层析与生物质谱联用技术在生物体内蛋白质药物分析中的应用研究

Studies on the Application of Affinity Chromatography Coupled with Bio-Mass Spectrometry in the Analysis of Protein Drugs in Vivo

蛋白质药物作为重要的生物技术药物之一，被广泛的应用于医药治疗与组织工程等领域。

Protein drugs are one of the most important biological drugs in the field of medical treatments and tissue engineering today .

另一种口服蛋白质药物的投药方法，是将药物包裹于可以穿过肠壁的携带分子之内。

Another strategy to deliver protein-based drugs orally is to encase them in carrier molecules that can ferry them across the gut lining .

把蛋白表面连接水溶性聚合物可以减弱蛋白质药物被免疫系统识别出来，从而增加蛋白质的循环时间。

Linking water-soluble polymers on the protein surface can protect proteins from recognition by the immune system and hence increase the protein circulation time .

回国一个月后，他和他的团队升级了新型生物反应器，使他们能够从生菜中提取出蛋白质药物。

After a month , he and his team upgrade a new model of bioreactor that allows them to produce protein drugs from lettuce .

蛋白质药物与通常药物之间的差别在于，前者必须以注射形式给药，后者可以通过口服的形式给药。

Among the differences between protein drugs and pharmaceuticals is that the former must be administered by injection land the latter are delivered in pill form .