苦参素

苦参素对小鼠肝细胞Bcl-2，Bax表达的影响

Effects of oxymatrine on expression of Bcl-2 and Bax in mice hepatocytes

目的：研究苦参素对成纤维细胞增殖及Ⅲ型原胶原mRNA表达的影响，探讨其抗纤维化的作用机制。

Objective : To study the effect of oxymatrine on fibroblastic proliferation and procollagen mRNA expression in search of effective medicine for liver fibrosis .

苦参素对Hela细胞增殖及凋亡的影响

Effects of Matrine on proliferation and apoptosis of Hela cells in vitro

阿德福韦酯联合苦参素胶囊对慢性乙型肝炎患者HBV复制及T淋巴细胞亚群的影响

Effects of adefovir dipivoxil in combination with Marine Capsules on HBV replication and T lymphocyte subsets in patients with chronic hepatitis B

目的：建立用HPLC法测定血浆中苦参素浓度的方法，考察苦参素注射液犬体内的药动学过程。

OBJECTIVE To establish a method for determining oxymatrine in plasma with HPLC and to determinate the pharmacokinetics process of oxymatrine injection in dogs .

苦参素对HBsAg转基因小鼠血清Th1和Th2细胞因子水平的影响

Effects of oxymatrine on serum levels of Th1 / Th2 type cytokines in HBsAg transgenic mice

目的建立RP-HPLC法测定苦参素磷脂复合物胶囊体外溶出度的方法。

Aim To establish a method for the dissolution determination of Kushenin-phospholipid complex capsule by RP-HPLC method .

清肝化瘀方药、苦参素对大鼠肝癌形成过程中ERK蛋白的影响

Effect of Liver-clearing and Stasis-removing Decoction and Matrine on ERK in Hepatocellular Carcinoma of Rats

结论：干扰素α-2b联合苦参素治疗慢性乙型肝炎疗效及随访观察疗效B基因型优于C基因型。

Conclusion : The clinical therapeutic effect of interferon 2-2b combined with matrine is very good for chronic hepatitis B , and the clinical therapeutic effect of genotype B is superior to that of genotype C.

目的探讨苦参素胶囊治疗慢性乙型肝炎（CHB）的疗效。

To evaluate the effect of Oxymatrine capsule on chronic hepatitis B ( CHB ) .

结论苦参素可能通过影响成纤维细胞的增殖、抑制成纤维细胞的分裂和ECM的合成发挥其抗肝纤维化作用。

Conclusion Oxymatrine can inhibit the proliferation and the ECM synthesis of NIH / 3T3 fibroblasts and thus play an important role in its anti-fibrosis mechanism .

苦参素诱导人胃癌MGC-803细胞凋亡的体内外实验研究

Experimental study on oxymatrine inducing apoptosis of human carcinoma cells MGC-803 in vivo and in vitro

结论拉米夫定联合苦参素具有协同抗HBV效应，能明显改善慢性乙型肝炎患者临床生化指标。浙江、广东省耐药监测项目中耐药肺结核治疗现况研究

Conclusion lamivudine combined oxymatrine had synergistic treatment efficacy for treating HBV . Research on treatment efficacy of the patients with drug resistance in the project for drug resistance surveillance in Guangdong and Zhejiang provinces

目的：评价干扰素联合苦参素治疗慢性乙型病毒性肝炎（CHB）的疗效。

OBJECTIVE : To evaluate the therapeutic effects of interferon combined with kushenin in the treatment of Chronic Hepatitis B ( CHB ) .

建立了HPLC-MS法测定人血浆中苦参素浓度，并用于其胶囊的药物动力学研究。

A HPLC-MS method was established for the determination of oxymatrine in human plasma , and was used in the pharmacokinetic study of its capsules .

结论Ara-AMP、苦参素、胸腺肽联合治疗CHB疗效可靠，无毒副作用。

Conclusions CHB therapy with Marine , Ara - Amp and Thymic peptide has reliable effect but no side effect .

结果苦参素可抑制NIH/3T3成纤维细胞的增殖，减少S期细胞，降低细胞增殖指数，抑制ECM的合成，并呈剂量依赖关系。

Results Oxymatrine could inhibit the proliferation of NIH / 3T3cell , decrease the cell cycle at S phase and the cell proliferation index , and inhibit the synthesis of ECM components in a dose-dependent manner .

与CCl4模型组比较，经甘珀酸钠苦参素1∶12、∶1包合物处理的小鼠血清GOT、GPT水平较低（P<0.05，或P<0.01）；

Compared with the model group by CCl_4 , the GOT and GPT levels in serum were lower in the clathrate compound of 1 ∶ 1 and 2 ∶ 1 ( P < 0.05 , P < 0.01 ) .

目的探讨苦参素对人膀胱癌T24细胞的抑制作用及其可能机制。

Objective To study antitumor effects and mechanism of oxymatrine ( OMT ) on human bladder cancer T24 cell line in vitro .

方法：乳鼠脑内接种半数感染剂量的CMV，运用光学显微镜和透射电镜观察苦参素对脑组织病理形态的影响。

Methods : CMV of TCID 50 was inoculated into the brain of the newborn mice , and the morphological change in the brain tissue infected by CMV was observed with light microscope and transmission electron microscope .

1.25mg/ml苦参素作用72h后分别是54.52%，44.42%，1.06%，凋亡率是5.37%；

Exposed 1.25mg/ml OMT for 72h , they were 54.52 % , 44.42 % , 1.06 % , respectively and apoptosis cells were 5.37 % ;

目的探讨苦参素注射液（Oxymatrine，OM）联合促肝细胞生长素（pHGF）治疗慢性乙型重型肝炎（CSHB）的临床价值。

Objective To observe the clinic therapeutic effect of oxymatrine ( OM ) combined with promoting hepatocyte growth factor ( pHGF ) on chronic severe hepatitis B ( CSHB ) .

探讨国产抗病毒药物单磷酸阿糖腺苷（Ara-AMP）、苦参素、胸腺肽联合治疗慢性乙型肝炎（CHB）的疗效。

Objective To study the effects of anti-virus agents Marine , Adenine arabinoside Adenosine monophosphate ( Ara-Amp ) and Thymic peptide in treatment of chronic hepati - tis B ( CHB ) .

室内毒力测定中，0.3%苦参素3号LC50最低，其次是4号和1号，它们分别是20%三氯杀螨醇的0.02869倍0、。

The result showed that the toxicity measurement indoors 0.3 % matrine ( the 3rd ) was the lowest in LC_ ( 50 ), the second was the 4th and 1st .

苦参素注射液治疗56例肿瘤化疗后白细胞减少症

Treatment with Matrine for Leukopenia Attributable to Chemotherapy in 56 Cases

结论：苦参素片与胶囊具有生物等效性。

CONCLUSION : The tablet and capsule of kushenin were bioequiva_lent .

博尔泰力（苦参素）治疗慢性乙型肝炎临床疗效观察

A study of Marine ( Oxymatrine ) treatment chronic hepatitis B

苦参素联合微卡治疗慢性乙型肝炎

Marin Combined with M.vaccae in the Treatment of Chronic Hepatitis B

苦参素对维持性血液透析患者营养不良及贫血的影响

Effects of Oxymatrine on Malnutrition and Anemia in Maintenance Hemodialysis Patients

苦参素对大鼠慢性肝损伤的防护作用

Protective effects of oxymatrine on chronic liver damage in rats