自发活动

一种测定小鼠长时间自发活动时空特点的新方法

A novel method for continuously assessing the spatio temporal properties of locomotor activity in mice

鼠、猪与猴自发活动试验方法学研究进展

Progress in study of methodology of spontaneous locomotor activity in rats , pigs and monkeys

结果：大鼠的自发活动数、骨密度增加，血Ca、血P、骨Ca、骨P以及骨中HP含量增加，血中ALP活性降低。

RESULTS : Both voluntary activity and bone density of the treated rats were increased .

结果：脑室注射IL-1β可导致大鼠的自发活动减少。

Results : The locomotion activity of rats was decreased by intracerebroventricular injection of IL-1 β .

目的：观察外源性白介素-1β（IL-1β）对大鼠自发活动的影响。

Objective : To investigate the effect of interleukin-1 β( IL-1 β) on locomotion activity in rats .

刺激强度较强，A类和C类纤维共同传入时，能易化记录部位的自发活动。

When current intensity of stimulating saphenus nerve was fairly strong and type A and C fibres were afferent together , the spontaneous activity of neurons in primary somatosensory cortex was facilitated .

侧脑室注射40μg的东莨菪碱后，海马神经元的自发活动无明显改变。

After intraventricular injection of scopolamine ( 40 μ g ) which inhibits the conditioning performance , the discharge rate of spontaneous unit activity showed no obvious changes ;

目的研究牡丹皮流浸膏（extractofmoutancortex，EMC）对多种实验性癫痫模型及小鼠自发活动的影响。

Objective The effects of the extract of moutan cortex on experimental seizures and autonomic activity were studied in mice .

主要观察指标：各组小鼠治疗后自发活动、力竭游泳时间、肾上腺维生素C含量、血清单胺类递质及其代谢产物含量的变化。

MAIN OUTCOME MEASURES : After treatment , the spontaneous exploratory activity , and the forced-swim time , the vitamin C content in adrenal gland and the changes in monoamine neurotransmitter and its metabolites were measured .

结果前脑重复缺血再灌注并没有明显影响小鼠在新异环境中的自发活动和探究行为，但使小鼠的学习记忆能力显著下降，同时伴随脑内SOD活性降低和MDA含量升高。

RESULTS Ischemia-reperfusion did not affect the spontaneous behavior , but impaired learning-memory , declined the activity of SOD , and increased the level of MDA in mice .

EGTA溶液阻断了反应并抑制自发活动，其结果与Li~+的作用类似。

EGTA solution blocks the responses and induces the same effect on the spontaneous activity as Li .

我们发现该药物显著地压制GABA神经元的自发活动水平，提示水杨酸钠通过提高中枢听觉系统的兴奋性诱导耳鸣。

It has been found that NaSal significantly suppresses the functional activity of GABA neurons , suggesting that NalSal raises excitability in the central auditory system to induce tinnitus .

自发活动试验结果：给药后30min，各受试药物组的自发活动与对照组相比均无显著性差异（P0.05）；

Spontaneous motor activity : 30 minutes after administration , no significant difference was found among the four test drugs groups and the control group ( P 0.05 );

灵芝能减少小鼠的自发活动，其ED（50）为2.65g/kg，此外尚能增强戊巴比妥的镇静作用；

It can also reduce the spontaneous activity of mice and the ED_ ( 50 ) is 2 . 65g / kg . In addition , it can somewhat enhance the sedation of pentobarbital .

结果芋螺毒素SO3（0.75~12μg·kg-1，icv）引发小鼠剂量依赖性震颤，显著降低小鼠自发活动计数；

Results CTX SO3 ( 0.75 ~ 12 μ g · kg ~ - 1 , icv ) could cause a dose-dependent tremor action in mice and significantly decrease their spontaneous activities .

61日龄：母爱剥夺组大鼠自发活动的总活动时间较对照组显著延长（P0.01），而其他指标差别均无统计学意义。

On postnatal day 61 : The time of activities of rats in maternal deprivation group was significantly increased , compared with rats in control group ( P0.01 ), while there were no difference in distance of activity between two groups .

结果4种药物应用后，各剂量组小鼠均出现少动、嗜睡症状，与给药前及CMC-Na组相比，各剂量组小鼠自发活动数均显著减少（P<0.05），并呈剂量反应关系。

Compared with pre-drug and CMC-Na group , spontaneous activity of mice decreased obviously at each dose ( P < 0.05 ), and the changes were relative to the doses .

根据生理特性的不同，化学感受器又可划分为R1和R2两类，R1化学感受器无自发活动，可被肾缺血激活；

The latter is further classified as R1 and R2 chemoreceptors . Some of the mechanoreceptors have a spontaneous discharge under control conditions . R1 chemoreceptors have no spontaneous activity and respond to renal ischemia .

结果：YZR能抑制小鼠自发活动，与戊巴比妥钠合用有协同作用。

Results : This oral liquid could reduce the spontaneous activity and cooperate with pentobarbital sodium to increase sleep time of mice .

结果显示βAP组大鼠在新异环境中自发活动和探究行为减少，Y-迷宫分辨学习记忆减退，同时海马SOD活性降低、MDA含量明显增加，与对照组比较，有显著性差异（P<0.05）。

The spontaneous activity and response of the β _AP group rats to novel environment in the open field were significantly decreased , and the ability of Y_maze discrimination learning_memory were attenuated . The content of SOD decreased and MDA increased , P < 0.05 compared with control group .

自发活动试验：分别于各组末次给药30min、90min两个时间点观测小鼠自发活动，记录5min的自发活动次数。

Spontaneous motor activity : The spontaneous motor activity of mice was observed at 30 and 90 minutes after the last administration to record the activity in 5 minutes .

结果大剂量ONO1078（5.0mg·kg-1）对小鼠自发活动有抑制作用，但是未观察到其它明显的神经作用。

RESULTS ONO 1078 had suppressive effect on spontaneous locomotor activity in a larger dose ( 5.0 mg · kg - 1 ), but no other significant central effects were observed in mice .

结果TFSB（30~300mg·kg-1）不影响自发活动，对戊巴比妥钠诱导睡眠时间和睡眠潜伏期无明显影响，对肌肉协调能力和运动协调能力没有显著影响（没有肌肉松驰作用）。

Results : TFSB ( 30 ~ 300mg · kg-1 ) produced neither influence on latency time and sleeping time induced by Pentobarbital sodium and spontaneous activity nor muscle and motor coordination ( no relaxing muscle ) .

方法通过YXL对实验小鼠自发活动的影响，对戊巴比妥钠阈下剂量、阈剂量小鼠睡眠时间和对硝酸士的宁致小鼠惊厥的影响，研究YXL镇静、催眠、抗惊厥作用。

Methods Mice spontaneous activities , mice sleep time induced by sodium pentobarbital in the threshold dose and under the threshold dose and mice convulsion induced by strychnine nitrate were observed to evaluate the sedative , hypnotic and anticonvulsive actions of YXL .

首先记录600s的自发活动，随后每隔4s给予一次胡须刺激，持续1000s。每个刺激的持续时间为50ms。麻醉深度的由尾静脉泵注丙泊酚维持。

Firstly record the spontaneous activities for 600s , then record the evoked activity for 1000s with stimulated the whisker every 4 s , the duration of stimulation was 50 ms. Anesthesia levels were modulated by the infusion rate of propofol administrated from tail vein .

对N-MP的中枢作用初步研究表明，它能减少小鼠自发活动，加强戊巴比妥钠所致小鼠的入睡和对抗苯丙胺的兴奋作用。

The experimental results showed that N-MP has marked sedative-hypnotic effects , it can reduce spontaneous activities in mice , antagonize excitation induced by amphetamine and facilitate the onset of a state of sleeping induced by sodium pentobarbital sodium .

不同剂量腺苷对大鼠自发活动的影响

Effect of Different Dosage Adenosine on the Locomotion Activity in Rats

诺米芬新对慢性吗啡处理后小鸡自发活动量的影响

Effects of nomifensine on locomotor sensitization in chicks pretreated with morphine

而对自发活动基本没有影响。

It has statistically no influence on mice spontaneous activities .

提示动物的自发活动行为出现了抑制现象。

This suggest the locomotor activities were inhibited . 2 .