脂溶性药物

pKa值7.9942。结论：染料木黄酮为弱酸性脂溶性药物。

The pKa value of genistein was 7.9942 . CONCLUSIONS Genistein is a kind of subacid and fatsoluble drug .

生物利用度较只含有植物油的VES制剂提高了1.54倍，说明SEDDS是一有效的提高脂溶性药物日服吸收的途径。

SEDDS has improved the bioavailability of VES significantly . The date suggest the potential use of SEDDS to provide an efficient way of improving oral absorption of lipophilic drugs .

聚乙二醇1000维生素E琥珀酸酯（TPGS）是维生素E的水溶性衍生物，在国外现已广泛应用于制剂研究中，作为增溶剂、吸收促进剂、乳化剂、增塑剂以及脂溶性药物传递系统的载体。

Alpha-tocopherol polyethylene glycol 1000 succinate ( TPGS ), a water-soluble derivative of natural-source vitamin E , has been extensively applied at abroad as a pharmaceutical excipient , such as solubilizing agent , absorption enhancer , emulsifier , plasticizer and vehicle for controlled drug delivery application .

海藻酸微胶囊作为脂溶性药物缓（控）释载体的研究

Research on Alginate Microcapsule as a Controlled Released Carrier of Lipophilic Drugs

结论醇质体能显著促进脂溶性药物非那甾胺的经皮渗透，增加药物在皮肤中的蓄积，有望成为一类新型的皮肤给药制剂。

CONCLUSION Ethosomes can improve the transdermal permeation and skin accumulation of finasteride .

皮肤不同层对脂溶性药物经皮渗透的影响

Influence of different layers of skin on the percutaneous absorption of drugs with different lipophilicity

药物在溶剂体系中的溶解性及与高分子材料的相容性是影响药物能否被纤维成功包埋的直接因素，一般脂溶性药物易于被脂溶性的高分子纤维包埋。

The drugs ' solubility in the solvent system and compatibility with the polymer materials will directly influence the encapsulation effect . Generally , lipophilic drugs can be encapsulated inside the lipophilic polymer fibers .

白桦脂酸是难溶性药物，可以通过增加药物的溶出度，进而提高药物的生物利用度。

The bioavailability of betulic acid preparation can be increased by increasing the dissolution rate and the solubility .