肥胖基因

Leptin是肥胖基因的编码产物。

Leptin is the product of the obese gene .

leptin是肥胖基因（Obesegene，OB基因）的蛋白产物，具有广泛的生物学功能。

Leptin is the protein product of obese gene . Leptin has many biological functions .

人肥胖基因（Obese）转基因小鼠动物模型的建立

Establishment of a Transgenic Mouse Model for Human Obese Gene

利用PCR技术自外周血白细胞染色体DNA中扩增获取了肥胖基因（ob基因）的外显子2和3序列。

The exon 2 , 3 of ob gene were isolated from chromosome of human peripheral leucocytes by means of PCR technology .

自从1994年Zhang首次克隆出肥胖基因（Obesegene，ob基因）之后，有关ob基因的研究已有很多报道。

Since obese gene ( ob gene ) was first cloned and reported in 1994 , it has been studied profoundly .

目的：克隆人肥胖基因瘦素蛋白（leptin）编码区cDNA序列，并构建其原核表达载体。

Objective To clone the sequence of cDNA of human obese gene ( leptin ) coding area and construct a prokaryotic expression vector .

瘦素（Leptin）是由肥胖基因（ob）编码脂肪细胞产生的与代谢密切相关的蛋白激素。

Leptin is a proteohormone encoded by the obese gene and produced by adipocytes , which is involved with metabolism .

动物肥胖基因（ob）的研究进展

Advance in Animal Obese gene

瘦素（leptin）是肥胖基因（Obesegene，ob基因）的产物，具有抑制摄食、调节脂肪沉积与能量代谢的功能。1950年，Ingalls等首次发现并提出了ob基因的概念。

Leptin , the product of obese gene , has the faction of suppressing food intake , preventing obesity and regulating energetic metabolism .

目的探讨大量脂肪去除术后肥胖基因（Ob基因）、血脂、肿瘤坏死因子－α（TNF－α）表达受到的影响。

Objective To study the changes of Ob gene expression , blood lipids , tumour necrosis factor -α( TNF -α) after massive lipectomy .

本文对影响肉质的脂肪酸结合蛋白基因、肥胖基因、leptin基因、黑素皮质受体基因、脂蛋白脂酶基因、激素敏感脂酶基因的国内外研究状况加以综述。

In this paper , the research advance of FABP genes , obese gene , leptin gene , MCRs genes , LPL gene , HSL gene affecting meat quality in animals are reviewed .

肥胖基因（ob）是近年刚被克隆的新基因，该基因产物Leptin是反映体内脂肪含量和调节体重的重要信号因子。

Obese gene ( ob ) is a novel gene cloned recently . The product of ob gene Leptin is an important signal reflecting body fat mass and controlling body weight .

目的：探讨广西肥胖症、非胰岛素依赖性糖尿病（NIDDM）是否与肥胖基因突变有关，同时观察广西壮族汉族人群的肥胖基因（ob基因）多态性。

Objective : To study the relation between obesity , NIDDM and ob gene mutation , and to observe the ob gene polymorphism of Zhuang and Han peoples in Guangxi .

肥胖基因发生突变时，ob基因表达减弱，血瘦素水平下降，引起肥胖及糖尿病等。

When the obese gene had the mutation , the ob gene expression weakened , the blood thin element level dropped , which would cause obese or diabetes and so on .

目的：探讨肥胖基因的表达产物&肥胖蛋白（OP）与非胰岛素依赖型糖尿病（NIDDM）发生和发展的关系。

Objective : To explore the role of the obese protein ( OP ) of the obese gene expressive product in the genesis and development of noninsulin dependent diabetes mellitus ( NIDDM ) .

瘦素（leptin）是肥胖基因的产物，属于Ⅰ型细胞因子。在哺乳动物中，leptin主要由脂肪细胞合成与分泌，是调控摄食、能量代谢和繁殖等生理过程的重要激素。

Leptin , the protein product of the obese gene , is a type-I cytokine hormone secreted primarily by adipocytes in mammals , which plays a key role in the regulation of food intake , energy expenditure and reproduction .

目的探讨肥胖基因表达产物肥胖蛋白（OP）与儿童单纯性肥胖症发病及预后的关系。

Objective To investigate the relationship between obese gene expressive product obese protein ( OP ) and the pathogenesis and prognosis of simple obesity in 30 children with normal body weight ( control group ) .

从筛选到的阳性克隆中分离出肥胖基因，测定其序列，分析表明该片段为肥胖基因cDNA的部分序列，编码167个氨基酸组成的多肽，是成熟肽的主体部分。

The ob gene was isolated and sequenced from the positive clones screened . Sequence analysis suggested that this fragment was partial sequence of ob cDNA and coded 167 amino acid residues , which constituted the major part of leptin mature protein .

肥胖基因（ob）是近年来克隆的新基因，该基因产物-Leptin（瘦蛋白）是反映体内脂肪含量和调节体重的信号因子，具有调节摄食行为，减少能量消耗和降低动物采食量的作用。

Obese gene is a novel gene cloned recently , products of obese gene is leptin , which is signal factor affecting body fat content and body weight and can decrease energy loses and feed intake .

资料综合：瘦素（Leptin）是由肥胖基因（ob）编码，脂肪组织分泌的蛋白质，已知其主要功能是调控进食、能量消耗及体质量。

DATA SYNTHESIS : The leptin was codes by the obese gene ( ob ), the fatty tissue secreted the protein , the known its main function was the regulation eats food , the energy consumption and the body mass .

背景Leptin，又称瘦素，1994年由Zhang等首次发现，是肥胖基因表达的一种蛋白质，与下丘脑的特异性受体结合通过减少摄食量和增加能量消耗来调节体重和能量平衡。

Background Leptin , the product of the obese gene , was identified by zhang [ 1 ] etal in 1994.It is known to regulate homostasis and energy balance by reduce food intake and increase energy expenditure via interaction with specific receptors in the hypothalamus [ 2-4 ] .

leptin是肥胖基因蛋白，因其在机体饮食行为、能量代谢、脂肪组织的合成与分解代谢中起重要调节作用，而成为肥胖发生与防治研究的热点。

Leptin , the protein of obesity gene , take an important role in the regulation of food intake , energy metabolism , and lipid metabolism . All this physiologic effect of leptin catch the attention of many researchers engaged in the development and prevention of obesity .

北京鸭肥胖基因的克隆与分析

Molecular Cloning and Analyzing of Obese Gene cDNA in Pecking Duck

肥胖基因在多基因遗传中确定单一基因绝非易事

Obesity genes Identifying single genes involved in polygenic inheritance is not easy

摄食状态及胰岛素水平对大鼠脂肪组织肥胖基因表达的影响

Effects of insulin and food intake on OB gene expression in rats

莱芜黑猪肥胖基因的多态性分析

Polymorphic Analysis of Obese Gene in Laiwu Black Pigs

胰岛素对胎盘肥胖基因表达的影响

Action of Insulin for Obese Gene Expression in Placenta

淡水养殖鱼类肥胖基因克隆与组织表达研究

Molecular Cloning and Tissue Expression Analysis of Leptin Gene in Freshwater Cultured Fishes

肥胖基因的分离及其在大肠杆菌中的表达

Isolation of ob Gene and Its Expression in E.coli

人类肥胖基因克隆和表达

Cloning of Human Obese Gene and its Expression