肉芽组织

祛瘀生肌法对实验性创面新生肉芽组织中EGFR、FN水平的影响

Influence of Stagnation-Removing and Muscle-Producing Method on the Levels of EGFR and FN of Experimental Wound Granulation Tissue

目的探讨感觉神经肽P物质（SubstanceP，SP）对碱性成纤维细胞生长因子（Basicfibroblastgrowthfactor，bFGF）表达的调控作用及其在SP促离体培养的肉芽组织成纤维细胞增殖中的作用。

Objective To explore the regulatory effect of sensory neuropeptide substance P ( SP ) on the expression of basic fibroblast growth factor ( bFGF ) and the proliferation promoting effect of bFGF on the in vitro cultured granulation tissue fibroblasts induced by SP.

P物质在诱导肉芽组织成纤维细胞增殖中的作用

Effects of substance P on granulation tissue fibroblasts proliferation and expression of basic fibroblast growth factor mRNA

感觉神经肽P物质对肉芽组织成纤维细胞核因子-κB的激活及生物学作用

Neuropeptide substance P for the activation of nuclear factor - κ B of granulation tissue fibroblasts and its biological function

皮肤肉芽组织中VEGF、PCNA和ED1表达的变化

Change of expression of VEGF 、 PCNA and ED_1 in skin granulation tissue

病理学检查发现，bFGF可刺激成纤维细胞增殖及胶原合成，促进毛细血管增生和肉芽组织形成。

Pathological observation showed that bFGF stimulated proliferation of fibroblast and collagen synthesis .

结果表明，TGFβ蛋白可在动物体内诱导局限性肉芽组织形成；

The TGF β protein can induce localized acestoma tissue formation within the boby of the animals .

钙拮抗剂在P物质激活肉芽组织成纤维细胞核因子-κB中的作用

Effect of antagonist of Ca ~ ( 2 + ) in the activation of nuclear factor - κ B of granulation tissue fibroblasts induced by substance P KIDNEY CALCIUM MILK

结果TGFβ1主要表达于肉芽组织、成纤维细胞、巨噬细胞及血管内皮细胞。

Results TGF - β 1 staining was observed in the granulation tissue , fibroblasts and endothelial cells of blood vessels .

组织学检查发现，bFGF治疗组皮瓣下肉芽组织层明显增厚，并有大量毛细血管和成纤维细胞增生；

Abundant fibroblasts and capillaries were noticed in the granulation tissue in wound bed in bFGF treated groups .

肝素可增强bFGF促进创面肉芽组织生长、毛细血管增生、纤维母细胞增殖及细胞DNA合成。

Heparin could enhance activity of bFGF to stimulate formation of granulation tissue , regeneration of capillary , proliferation of fibroblast and DNA synthesis .

OPN组肉芽组织层明显较血清组、EGF组薄，新生毛细血管数量亦较少，个别部位肉芽水肿明显。

Granulation tissue of OPN was thin than that of serum group and EGF group .

病理学检查：B组术后2周局部组织以急性化脓性炎症为主，4周时以肉芽组织增生和纤维组织形成的慢性炎症反应为主；

Pathological changes : In the Group B , the main pathological changes were acute suppurative inflammation after two weeks , and chronic inflammation with hyperblastosis of granulation and fibroplasias after four weeks .

结果：31例放射性溃疡患者在MEBO的治疗下有28例获得自行愈合，3例经培养肉芽组织创面洁净后行肌皮瓣或游离植皮修复。

Results : 28 cases healed spontaneously and 3 cases healed after skin grafting .

肉芽组织中间质细胞、单核巨噬细胞和多核巨细胞表达TGF-β、bFGF。

Expression of TGF - β and bFGF was from mesenchymal cells , macrophages and multinuclear giant cells in the granulation tissue .

取创面肉芽组织及其血液，测定纤维连接蛋白（Fn）及创面碱性成纤维因子（bFGF）的含量，同时观察伤口愈合情况，进行比较。

The level of Fn and b-FGF were measured in wound tissue specimen and blood , the healing of wounds were observed .

结论：胆脂瘤、肉芽组织和脑组织横向驰豫时间（T2）具有可区别的范围，MRI中T2值有助于鉴别上述不同的病理类型。

Conclusion : The T2 relaxation times of cholesteatoma granulation tissue and brain tissue are different range so the pathologic tissue above can be differentiated .

87例均伴有患侧轻~中度肾盂积水，其中46例合并结石远端输尿管狭窄，69例合并息肉或肉芽组织包裹，21例为ESWL治疗失败后。

Among them , 46 cases with ureteral stricture , 69 cases with polypus and 21 cases fail of ESWL .

周边的肉芽组织，由于炎性的富血供和血管通透性的增高，导致在T2序列上显示为明显的高信号。

The surrounding granulation tissue , with its inflammatory hypervascularity and increased vascular permeability , will be markedly hyperintense on T2-weighted images .

MΦ主要表达于粘膜固有层；TGFβ1主要表达于肉芽组织、成纤维细胞、MΦ及血管内皮细胞。

Macrophage staining was found at the intrinsic layer under mucosa membrane , TGF β 1 staining at the granulation tissue , fibroblasts and endothelial cells of blood vessels .

目的：研究感觉神经肽P物质（SP）对肉芽组织成纤维细胞核因子-κB（NF-κB）的激活作用，以探讨其生物学作用的信号机制。

AIM : To study the effect of neuropeptide substance P ( SP ) on the activation of nuclear factor κ B of granulation tissue fibroblasts so as to explore its signal transduction mechanisms of biological function .

组织形态学观察可见VAC组创面炎症反应较轻，肉芽组织生长和再上皮化速度均较对照组快。

The VAC-treated wounds also showed less severe inflammation and higher velocity of formation of granulation tissue and reepithelization .

目的：观察抗感染喷剂对大鼠皮肤创伤修复模型修复面积及肉芽组织中表皮生长因子（EGF）表达的影响。

Objective : To observe the effect of Kangganran spray on repaired area and expression of EGF in wounded tissue of skin injury model rats .

方法：2例支气管结核、1例气管鳞癌和1例气管腺样囊性癌，在镍钛合金气道支架置入后存在新生物或肉芽组织过度生长，应用APC治疗。

Methods : Two cases of endobronchial tuberculosis , 1 case of squamous cell carcinoma of trachea and 1 case of adenoid cystic carcinoma .

术后第4～7天，血清组、EGF组可见肉芽组织逐渐成熟，其中成纤维细胞和新生毛细血管含量丰富，胶原纤维增多。

For 4 ~ 7 days after operation , granulation tissue of serum group and EGF group became mature , and had new capillary and fibroblasts .

实验揭示了不同分子量的HA对伤口收缩、肉芽组织血管生成和伤口愈合强度的作用不一。

The study revealed that HA with different molecular weights had different actions on the contraction of wounds , the angiogenesis of the granulation tissues and the healing strength of the wounds .

肉芽组织中EGFEGFR于伤后第3天从较低水平逐渐升高，至第9天达最高，然后明显降低。

EGF / EGFR was at low level at the 3rd day , then increased gradually and reached the peak at the 9th day , then declined .

观察2组肉芽组织出现时间（GT）、溃疡愈合时间（HT）、临床疗效及半年内溃疡复发情况。

Time of granulation tissue ( GT ) appearing and ulcer healing ( TH ), clinical effect and recurrence of ulcer in half year were observed .

结果：外用重组bFGF明显促进了肉芽组织和毛细血管的增生，增强了创伤性炎症增生反应，同时无促进腺泡细胞增生和涎液分泌的作用。

Results : It could be observed that bFGF promoted the proliferation of granulation tissue and capillaries but did not promote the proliferation of acinar cells of sialic secretion .

术后第4～7天，OPN组肉芽组织层明显较血清组、EGF组薄。

On the day 4 to 7 after operation , granulation tissue in OPN group was thinner than that in serum group and EGF group .