罗非昔布

然而，最近有报道显示应用另一种选择性COX-2抑制剂-罗非昔布-的患者中有心血管副作用的发生。

Unfortunately , cardiovascular side-effects have recently been reported in patients using another selective COX-2 inhibitor , rofecoxib .

罗非昔布是高选择性环氧化酶（COX-2）抑制剂，用于治疗骨关节炎，控制成人锐痛和痛经。

Rofecoxib , a COX-2 specific inhibitor , is approved for treatment of osteoarthritis , acute pain and primary dysmenorrhea .

目的：对比洛索洛芬和特异性环氧化酶2（COX2）抑制剂罗非昔布治疗膝骨关节炎（OA）的疗效和安全性。

Objective : To compare the safety and efficacy of loxoprofen and rofecoxib in treatment of knee osteoarthritis ( OA ) .

目的探索肾大部切除大鼠肾皮质环加氧酶2（cyclooxygenase，COX2）的表达及特异性COX2抑制剂罗非昔布对其的影响。

Purpose To investigate the regulation of cortical cyclooxygenase-2 expression in rats with subtotal renal ablation .

方法实验大鼠随机分为心肌缺血加选择性COX2抑制剂罗非昔布组、心肌缺血加选择性COX1抑制剂valerylsalicylate（VS）组和单纯心肌缺血组。

Methods The rats were randomly divided into 3 groups : MI group , MI plus rofecoxib group and MI plus valeryl salicylate group .

iNOS的表达显示：对照组iNOS阳性率为73.75%，罗非昔布组为52.50%，联合组为26.67%，罗非昔布组与对照组相比，差异有显著性（P<0.05）。

The expression of iNOS protein in isotonic saline group , rofecoxib group and combination group was 73.75 % , 52.50 % , and 26.67 % respectively , being significantly different among groups ( P < 0.05 ) .

方法建立裸鼠人胃癌原位种植转移模型，以罗非昔布给裸鼠灌胃，通过免疫组化Envision法检测罗非昔布对原位种植瘤胃癌组织中VEGF、iNOS蛋白的表达。

Methods After the models of human gastric carcinoma in nude mice by orthotopic transplantation were established , rofecoxib was administered intragastrically . The expressions of VEGF and iNOS were evaluated in the local tumors by Envision immunohistochemical method .

目的研究选择性COX2抑制剂罗非昔布对大鼠结肠肿瘤的防治作用及对肿瘤组织细胞外信号调节蛋白激酶（ERK/pERK）表达的影响。

Objective To study the effect of rofecoxib on colon neoplasm of rat induced by DMH and ERK / pERK expression .

目的：探讨环氧合酶-2抑制剂罗非昔布调节人胃癌SGC-7901裸鼠胃癌组织中血管内皮生长因子（VEGF）和诱导型一氧化氮合酶（iNOS）的表达对胃癌血管生成的影响。

Objective : To study on cyclooxygenase-2 inhibitor rofecoxib suppressing the angiogenesis of gastric carcinoma model established in nude mice bearing human SGC-7901 cell by regulating the expression of vascular endothelial growth factor ( VEGF ) and inducible nitric oxide synthase ( iNOS ) .

目的：考察长期服用高选择性环氧化酶2（COX2）抑制剂（罗非昔布）对大鼠关节软骨的影响。

AIM : To observe the influence of rofecoxib , a non steroidal anti inflammatory drug , administrated for a long term on the knee joints cartilage of rats .

罗非昔布和依他昔布在妇科小手术中的预先性镇痛效果

Comparison of Preemptive Analgesia Efficacy between Etoricoxib and Rofecoxib in Ambulatory Gynecological Surgery

高选择性环氧化酶-2抑制剂罗非昔布对大鼠关节软骨的影响

Influence of rofecoxib , a high selective cox-2 inhibitor , on articular cartilage of rats

罗非昔布对大鼠骨关节病关节软骨胶原的影响选择性脊神经后根切断术治疗痉挛性脑瘫

Influence of High Selective Cox-2 Inhibitor & Rofecoxib on the Collagen of the Articular Cartilage of Rats ' Osteoarthrosis

罗非昔布对裸鼠人胃癌原位种植瘤组织中血管内皮生长因子和诱导型一氧化氮合酶表达的影响

Effect of rofecoxib on expressions of VEGF and inducible NOS in human gastric carcinoma tissues established in nude mice by orthotopic transplantation

使用罗非昔布并且有心梗病史的患者心梗发生率为1.59%，而没有心梗病史的患者心梗发生率只有1.23%。

The MI rate ratio with rofecoxib use was1.59 in patients with a prior MI and1.23 in those without a previous MI .

结论：长期服用罗非昔布对大鼠骨关节病关节软骨的胶原代谢无明显影响。

Conclusion : Rofecoxib administrated for a long term has no harm influence on the collagenic metabolism of the rats ' knee joints cartilage in experimental osteoarthrosis .

结果：罗非昔布长期服用，对骨关节病关节软骨胶原的总量无影响，对Ⅱ，Ⅲ型胶原代谢无影响，而使Ⅰ型胶原含量明显增加。

Results : Rofecoxib has no significant influence on the total amount of collagen and the metabolism of the type ⅱ and type ⅲ collagen even it was administrated for a long term , but the amount of the type ⅰ collagen increased significantly .

奥曲肽联合罗非昔布在大多数效应范围的合用指数小于1，具有明显的协同作用。联合用药组的抑瘤率（971%）较罗非昔布组（732%）明显提高（P<005）。

The combination indexes of octreotide and rofecoxib in the majority of effect range were less than 1 . The inhibitory rate of xenograft in situ in the combined group ( 97.1 % ) was significantly higher than that in the rofecoxib group ( 73.2 % ) .