细胞周期特异性药物

植物碱类药物如多西紫杉醇（Taxotere）和羟基喜树碱（HCPT）是近年来发展较快的细胞周期特异性药物。目前，植物碱类药物联合顺铂是非小细胞肺癌常用的化疗方案。

The drugs of plant alkaloid , such as taxotere and hydroxycamptothecin ( HCPT ) are belong to CCSA that have rapidly developed in recent years .

结论：ORI有可能为细胞周期特异性药物，在体外能显著地抑制人食管癌细胞生长；ORI能有效地诱导人食管癌细胞凋亡，其作用机制与启动线粒体凋亡通路相关。

Conclusion : ORI probably belongs to cell cycle specific agents ( CCSA ) . It could inhibited the growth of human esophageal carcinoma cell obviously . ORI could induce apoptosis on the human esophageal carcinoma cell efficiently . The mechanism concerned with starting mitochondrium apoptotic pathway .

温热联合细胞周期特异性药物对恶性胸膜间皮瘤细胞的影响

Effects of Hyperthermia Combined Cell Cycle Specific agents on Malignant Pleural Mesothelioma

目的：通过体外实验观察D-甲硫氨酸（D-Met）合并应用细胞周期特异性化疗药物对胃癌细胞株代谢周期的影响。

Objective To elucidate the effect of D-methionine ( D-Met ) and its combination with phase-specific chemotherapeutic drug on the cell cycle of gastric cancer cell line in vitro .

背景与目的：拓扑替康（topotecan，TPT）是新一代水溶性、半合成喜树碱类衍生物，系拓扑异构酶I抑制剂、细胞周期特异性抗肿瘤药物；

Background & Objective : Topotecan , a semisynthetic water soluble derivative of camptothecin , is a potent inhibitor of DNA topoisomerase ⅰ and cell cycle specific antitumor agent ;

结论As2O3与5-Fu联合应用具有显著协同抗大肠癌作用，其机制可能与增强诱导大肠癌细胞凋亡、细胞周期特异性药物与细胞周期调控剂联合增效以及调控凋亡相关基因的表达有关。

Conclusions Arsenic trioxide combined with 5-Fu may obviously increase the anti-large intestine carcinoma effect , and maybe its mechanism is increasing apoptosis-inducing effect which is regulated by several genes and enhancing the anti-tumor effect of cell cycle specific agent combined with cell cycle regulatory agent .

本研究借鉴淋巴瘤联合化疗的成功经验，根据细胞动力学原理，选用细胞周期特异性药物长春新碱（VCR）和细胞周期非特异性药物环磷酰胺（CTX）小剂量间歇给药治疗SLE。

Drawing on the experience of combination chemotherapy in lymphoma , and according to cell kinetics theory , we choose vincristine ( VCR ), the specificity cell cycle drug and small doses of cyclophosphamide ( CTX ), the nonspecific cell cycle drug to treat SLE .

按肿瘤药物对各个细胞增殖周期敏感性的不同，可将其分为细胞周期非特异性药物和细胞周期特异性药物两大类。

The antitumor drugs can be devided into two kinds of CCNSA and CCSA according to the sensitive differences to each cell generation cycles .

髓系白血病细胞细胞动力学耐药是指处于G0期或增殖缓慢、细胞周期长于药物接触时间的白血病细胞对某些细胞周期特异性细胞毒药物产生耐药的现象。

Cytokinetic resistance of leukemic cells is a phenomenon that the blasts in quiescent state ( G0 ) or with longer cell cycle transit time than the duration of exposure to chemotherapy may escape cytotoxicity of cell cycle specific cytotoxic agents .