神经嵴

内皮素受体B基因启动子上游CpG岛甲基化对神经嵴细胞迁移的影响

Effect of Methylation at CpG Sites Upstream of Transcription Start Site of Endothelin Receptor B Gene on Migration of Neural Crest Cells

神经嵴细胞的发育异常可能参与了Cx43基因缺陷小鼠锥干部畸形的发病机制。

The abnormal distribution of cardiac neural crest cells is likely to contribute to the conotruncal malformations in Cx43-deficient mice .

毛囊bulge区神经嵴细胞体外分离培养及生物学特点（动物的）生育，繁殖，生殖

Isolation , culture and biological characteristics of neural crest cells from bulge area of hair whisker follicle in vitro

结论层粘连蛋白在无神经节细胞段表达增高是内在的，它引起肠壁神经嵴细胞的过早成熟定居导致HD的发生。

Conclusions The increased expression of laminin in aganglionic segment may cause early stop of the differentiation and migration of enteric nervous cells .

各月龄胎儿肾上腺组织均有hTR及hTRT表达，神经嵴细胞和继发皮质细胞内信号强于原发皮质细胞。

Fetal adrenal tissues of each gestational age had positive hTR and hTRT expressions .

我们推测胚胎基质的某种缺陷不仅损害了神经嵴细胞的移行，也影响ICC的分化和成熟。

It is suspected that the defect of embryo matrix inhibits either the migration of neural crest cell or the differentiation and maturation of ICC .

结论CAA基因与心脏发育密切相关。CAA基因表达受到心脏神经嵴细胞调控，剔除心脏神经嵴后其表达减少，影响了心肌细胞的成熟和分化，可能是导致心脏畸形发生的一个重要因素。

Conclusion CAA gene is closely associated with heart development , its expression was adjusted by cardiac neural crest , and its dysfunction may be an important factor leading to congenital heart defects .

目的：观察颅神经嵴细胞（CNCC）在体外是否可以向成骨细胞表型进行诱导分化。

AIM : To identify whether cranial neural crest cells ( CNCC ) can differentiate into osteoblasts in vitro .

Netrin-1作为神经轴突导向因子既能定向诱导神经轴突生长，也在肠神经嵴干细胞的迁移过程中发挥重要的作用。

Netrin-1 as an axon guidance factor plays an important role in guiding neuritis growth and the migration of gut neural crest cells .

目的Nitrofen大鼠膈疝模型中的心血管畸形多是神经嵴源性的，我们由此推论，除了心肺发育不良外，同是神经嵴源性的甲状腺、甲状旁腺和胸腺也可能异常。

Objective Experimental congenital diaphragmatic hernia ( CDH ) rat model reproduces not only diaphragmatic defect but also other anomalies such as thymus , thyroid and parathyroid which derived from neural crest .

其编码形成的蛋白Nell-1是近年来新发现的一种具有类表皮细胞生长因子编码结构并在颅面部等神经嵴来源的组织中特异性表达的分泌性蛋白。

Its coding protein Nell-1 , with EGF ( epidermal cell growth factor ) - like coding structure , is a recently discovered secreted protein and is preferentially expressed in neural crest-derived tissues like craniofacial region .

目前胚胎发育过程中神经嵴形成、迁移及分化的具体机制已基本明了，其中Notch、Wnt、Sox-10等多种信号通路及分子参与了神经嵴分化的调节。

The specific mechanism of formation , migration and differentiation of neural crest during the embryonic development has been understood basically now , it has been confirmed that Notch , Wnt , Sox-10 and other signaling pathways and molecules involves in the regulation of neural crest differentiation .

脑神经嵴干细胞体外培养方法的研究进展

Recent advances in cultured approaches of cranial neural crest stem cells

颅神经嵴干细胞成牙本质样细胞分化诱导的体内实验研究

Odontoblast-like cell phenotype differentiation of cranial neural crest stem cell in vivo

结论体外培养可成功获得心脏神经嵴细胞，且具有迁移特性和多向潜能分化能力。

These cells have ability of migration and potential of multi-directional differentiation .

心脏神经嵴细胞与先天性心脏病的发生机制

Role of Cardiac Neural Crest Cells in Pathogenesis of Congenital Heart Disease

血清对神经嵴细胞向神经胶质细胞分化诱导的体外研究

Induced differentiation of neural crest cells to glial cells in serum medium in vitro

重组人骨形成蛋白2诱导颅神经嵴细胞向肾上腺能神经元分化的研究

Recombinant human bone morphogenetic protein 2 induced cranial neural crest cells differentiating into adrenal neurons

比较胚胎和新生小鼠肠神经嵴干细胞体外增殖分化的实验研究

The proliferation and differentiation of the gut neural crest stem cells in embryonic and postnatal mice

神经嵴细胞可以发育出多种细胞，像神经元、软骨和骨细胞。

which can produce a variety of different cell types including neurons , cartilage and bone .

结果：（1）骨原始神经外胚层肿瘤来源于神经嵴的胚胎迁移细胞。

Results : ( 1 ) Osseous PNET originated from embryonic migrating cells of neural crest .

牙齿是由口腔上皮和神经嵴来源的外胚间充质相互作用而形成的。

Tooth development is the result of the interactions between ectoderm epithelium and mesenchyme from neural crest .

结果：成功地培养出小鼠的颅神经嵴细胞，其形态类似成纤维样细胞。

RESULTS : Cranial neural crest cells were cultured successfully . The shape of the cells were fibroblast-like .

当2个迁徙中的神经嵴细胞碰到一起时，它们会停止，伪足消失并改变方向。

When two migrating neural crest cells meet , they stop , collapse their protrusions and change direction .

躯干神经嵴干细胞的分离、纯化及其向雪旺细胞分化的实验研究

The Experimental Study of Trunk Neural Crest Stem Cell Isolated , Purified and Induced to Differentiating into Schwann Cells

下半部分的龟壳是胸甲，它由神经嵴细胞主导形成，

The development of the bottom half of the shell , the plastron , is driven by neural crest cells ,

本实验为肠神经嵴干细胞的后续深入研究和临床应用奠定了基础。

Our study will surely further the developmental research on gut neural crest stem cells and accelerate the application on patients .

外胚间充质是脊椎动物一个独特的结构，它包含了迁移来的颅神经嵴细胞及其衍生物。

Ectomesenchyme was an unique structure of vertebrates embryo composed of postmigratory cephalic neural crest cell ( NCC ) and its derivatives .

躯干神经嵴干细胞体外分离培养及其增殖、分化的实验研究

Culture , proliferation , and differentiation of trunk neural crest stem cells in early embryos of rats : an in vitro experiment

某些局部因素。如缺血、缺氧、免疫因素、巨细胞病毒和寄生虫感染等毁坏了肠壁内神经嵴细胞。

Some local factors to destroy intestine crest cells such as ischemia , hypoxia , immune factors , Epstein-Barr virus and parasite infection .