百日咳

你给你的孩子打过百日咳疫苗了吗？

Have you had your child vaccinated against whooping cough ?

因为孩子们没接种疫苗，麻疹、腮腺炎和百日咳又蔓延开来。

Measles , mumps and whooping cough are spreading again because children are not being vaccinated .

婴儿以一个月为间隔，接受三次百日咳疫苗的注射。

The infant receives three injections of pertussis vaccine at one-month intervals .

百日咳有强烈的传染性，因此最好将患者隔离4～6周。

The great communicability of whooping cough , males it desirable to isolate the patient for four to six weeks .

百日咳正在广泛流行。

Whooping cough is very prevalent just now .

ELISA在检测百日咳杆菌免疫原中的应用

The application of ELISA in the assessment of B. pertussis immunogen

河豚毒素单抗ELISA检测试剂盒的研制百日咳抗体酶联检测试剂盒的研制及其应用

Preparation and application of ELISA kit in detection of human antibodies against pertussis

大鼠创伤-失血性休克后腹腔巨噬细胞功能受损与百日咳毒素敏感的G蛋白的关系

The relationship of functional damage of peritoneal macrophages after traumatic hemorrhagic shock and pertussis toxin sensitive G protein

无细胞百日咳疫苗中活性PT的保护作用

Protection Role of Active Pertussis Toxin in Acellular Pertussis Vaccine

百日咳毒素和代谢抑制剂均能抑制CI引起的组胺和类胰蛋白酶释放。

Pertussis toxin and metabolic inhibitors were able to inhibit mast cell response to CI .

分子修饰的重组百日咳毒素S1亚单位的生物学和免疫学特性

Biological and immunological characterization of genetically altered S1 subunits of pertussis

无细胞百日咳疫苗生产用菌株CS的5种保护性抗原基因序列分析

Gene Sequencing of Five Kinds of Protective Antigens of CS Strain for Production of Acellular Pertussis Vaccine

百日咳毒素S1亚单位的分子修饰及在重组杆状病毒中的表达

Expression of genetically altered S1 subunits of pertussis toxin in recombinant baculoviruses

用G蛋白抑制剂百日咳毒素或GDPβs预处理细胞，能明显阻断DHT诱导的快速效应；

Pretreatment with G protein inhibitor either Pertussis toxin or GDP β S could significantly inhibited the DHT-induced fast effects .

百日咳毒素S1亚单位的表达及其免疫原性研究

Expression and Immunogenicity of Pertussis Toxin S1 Subunit

目的研究百日咳毒素S1（Pertussistoxins1subunit）亚单位在大肠杆菌中的表达及其免疫学特性。

Objective To express pertussis toxin S1 subunit in E. coli and study its immunogenicity .

因为APP中同样具有三聚体自转运黏附素，所以尝试利用百日咳的疫苗案例进行研究。

Because APP has a trimer in the same adhesin from a transfer , so try to use case studies of pertussis vaccine .

方法应用豚鼠脊髓匀浆加完全弗（氏）佐剂和百日咳杆菌免疫Wistar大鼠。

Methods Each Wistar rat was injected with Cavy 's spinal cord homogenate , mycobacteria and IFA , and Bordetella Pertussis bacilli .

实验证明菌苗中不仅含有百日咳毒素（PT）和丝状血凝素（FHA），而且还含有百日咳凝集素和百日咳粘着素。

The results showed that vaccine not only contains PT and FHA but also agglutinin and pertactin .

百日咳对EAE非敏感品系WIStar大鼠诱导EAE模型有重要作用，不同的注射部位对发病率有明显的影响。

Pertussis is important in EAE induction in un-susceptive Wistar rats and different injection places had different results .

A组大鼠用卵蛋白（OA）辅以百日咳杆菌菌苗和氢氧化铝为佐剂注射致敏。

The rats in group A were sensitized by injection of ovalbumin ( OA ) together with aluminum hydroxide and Bordetella pertussis as adjuvants .

人大肠、肺和扁桃体肥大细胞经代谢抑制剂和百日咳毒素预处理后，MT诱导其释放组胺的作用明显减弱。

Pretreatment of cells with metabolic inhibitors and pertussis toxin reduced dramatically histamine release from human colon , lung and tonsil mast cells by MT.

以上结果表明：亮啡肽诱导〔Ca2＋〕i升高是通过δ受体与百日咳毒素敏感的G蛋白耦联并诱导心肌细胞内钙释放所引起。

The results suggest that the LEK effect is mediated by coupling of G-protein with δ - receptor that induced Ca2 + release from the intracellular pool in myocytes .

百日咳杆菌LPF和FHA的纯化及其特性的研究

Studies on Separation , Purification and Properties of LPF and FHA from B. Pertussis

中国百日咳疫苗生产株S1和Prn蛋白基因序列分析

Sequencing of the S1 and Prn genes of three pertussis strains for the preparation of vaccine in China

目的：探讨兴奋性氨基酸、N甲基D天冬氨酸受体（NMDAR）在大鼠百日咳杆菌脑损伤中的变化及作用机制。

Objective : To explore changes and mechanism of EAAs and its specific N-methyl-D-aspartate receptor ( NMDAR ) on bordetella pertussis brain injury in rats .

7d后，使用添加完全福氏佐剂（CFA）的BMP和百日咳毒素免疫所有动物。

Seven days later , all animals were immunized with BMP in complete Freund 's adjuvant ( CFA ) and pertussis toxin .

方法向大鼠左颈内动脉注射百日咳杆菌悬浮液（0.2ml／kg体重），诱发感染性脑损伤模型。

Methods An IBI model was induced by injection of bordetella pertussis suspension ( BPS ) via the left internal carotid arteries of the rats .

PRN（百日咳粘着素，Pertactin，PRN）是无细胞百日咳组分疫苗的重要组成部分。

Pertactin is an important component of acellular pertussis vaccine .

因此，OMP及其组分经戊二醛处理后，有希望成为百日咳杆茵的无细胞疫苗。

Thus , the OMP and its fractions after glutaraldehyde detoxification might be adopted as acellular vaccine of B. pertussis .