白喉

当月20日,韦尔奇医生给生病的男孩比利做了检查,发现他得了白喉,这是一种主要针对儿童的致命传染病。

On the 20th of that month , Dr ． Welch examined a sick boy , Billy , and knew he had diphtheria , a deadly infectious disease mainly affecting children ．

伤寒Vi多糖、白喉、破伤风联合疫苗初探

Preliminary observation of typhoid Vi polysaccharide , diphtheria and tetanus combined vaccine

G（+）杆菌仅占2.8%，包括枯草杆菌和假白喉杆菌各1株。

While G ( + ) bacilli were isolated only in 2 occassions . ( 2.8 % ) .

免疫组织化学及RT-PCR检测白喉毒素A链基因表达；

RT-PCR and immunohistochemistry were used to detect the expression of DTA ;

Vero细胞法检测白喉抗毒素的研究

Vero Cell Assay for Determination of Diphtheria Antitoxin Titres

白喉毒素（diphtheriatoxinDT）是棒状白喉杆菌被茁噬菌体感染后分泌的一种外毒素。

Diphtheria toxin is an exotoxin secreted by Corynebacterium diphtheriae that has been lysogenized by β bacteriophage that carries the DT gene .

目的：探讨白喉毒素A（DTA）基因在肺腺癌基因治疗中的作用。

Aim : To investigate the effect of gene therapy with diphtheria toxin A gene ( DTA ) on human lung adenocarcinoma A549 cells .

人红细胞20S蛋白酶体的蛋白质组学表征及不同来源20S蛋白酶体异质性的研究白喉抗毒素是异性蛋白。

Proteomic Characterization of Human Erythrocyte 20S Proteasome and Analysis of Species-dependent 20S Proteasome Heterogeneity Diphtheria antitoxin is a foreign protein .

目的：构建含人乳癌DF3/MUC1启动子转录调控序列和白喉毒素A链（DTA）基因的重组表达载体。

Aim : To construct recombinant expression vector containing transcriptional regulation sequence of human breast cancer DF3 / MUC1 promoter and diphtheria toxin A-chain gene .

Vero细胞法测定DTP疫苗中白喉类毒素的效价与家兔皮内中和法（简称NT法）所得结果两法之间有一种平行关系，并且有很好的相关性，r＝0.93。

The diphtheria antitoxin titre of guinea pigs immunized with DTP Vaccine were detected by vero cell method and compared with those by rabbit skin neutralization test .

方法用PCR扩增白喉杆菌特异的白喉外毒素B基因（toxB）片段，琼脂糖凝胶电泳检测扩增产物。

Methods The specific fragment of diphtheria toxin B gene ( toxB ) was detected by PCR . PCR amplification products were examined by agarose gel electrophoresis .

目的探讨白喉毒素A链（DTA）基因在DF3/MUC1启动子调控下的杀伤作用。

Objective To explore the specific killing effect of diphtheria toxin A-chain ( DTA ) gene under control of the transcriptional regulation sequence of DF3 / MUC1 promoter .

1974年WHO推广扩大免疫规划（ExpandedProgramonImmunization，EPI），到1990年，预防麻疹、白喉、百日咳、破伤风、结核和脊髓灰质炎等主要传染病的疫苗免疫接种率已达到80%。

In 1974 , WHO promoted Expanded Program on Immunization ( EPI ) . In 1990 , measles , diphtheria , pertussis , tetanus , tuberculosis , polio and other major vaccines immunization rates had reached 80 % .

对6批吸附百日咳、白喉、破伤风、乙肝联合疫苗（DTPrHB），分别置不同温度、不同时间进行效力、安全稳定性试验。

The stability of six lots of DTP rHB combined vaccine was studied on conditions of storage including at different temperature and different time .

BA-ELISA法用于血清中白喉抗毒素检测的实验探讨

The Experimental Approach on the Detection of Diphtheria Antitoxin in Serum by means of BA - ELISA Method

精制白喉毒素单纯用甲醛解毒，解毒过程Lf/ml损失平均为14.81%，Lf/mgPN下降平均为13%；

During the course of detoxification of purified diphtheria toxin by using formalin alone , the average of loss rates of Lf / ml and Lf / mg PN were 14.81 % and 13 % , respectively .

白喉和破伤风免疫后抗体滴度的几何平均值（GMT）分别比免疫前增加4～28倍和7～11倍。

Concerning both diphtheria and tetanus antibody titres , the raise of GMT ranged from 4 to 28 and 7 to 11 fold in comparison with titres of pre-immunization .

大肠杆菌表达白喉毒素突变体CRM197高密度发酵工艺研究

The study on high-density fermentation of E.coli expressing diphtheria toxin mutant CRM197

本文报告用两种配方的吸附精制白喉&破伤风二联类毒素（DT），在浙江省黄岩县中学生和青工中进行免疫效果观察。

This paper reports the observation of the immune responses of adolecents and young workers immunized with two types of purified and adsorbed diphtheria-tetanus toxoids ( DT ) in Huang Yan county , Zhejiang province .

使用DTP后，发病率和病死率均大为下降，江苏省已多年未发生白喉病例。

After using DTP , the disease incidence rate and the case fatality rate greatly were the drop , Jiangsu Province many years have not had diphtheria case .

应用TFF微孔过滤澄清白喉、破伤风毒素培养液及超滤浓缩的试验

Experiments of Microporous Tangential flow Filtration in Clarification of Diphtheria and Tetanus Culture Suspension and Ultrafiltration in Concertration of Toxin Fluid

白喉杆菌异染颗粒Neisser法染色的新探讨

Neisser Stain of the Metachromatic Granules of C. diphtheriae

原位细胞凋亡检测，观察EWS-FLI1介导的白喉毒素A链基因表达后，肿瘤细胞的凋亡情况。

Apoptosis in situ was detected by TUNEL method .

含有硫柳汞的疫苗包括预防白喉、破伤风和百日咳（DTP）、乙型肝炎、B型流感嗜血杆菌、狂犬病、流感和脑膜炎球菌病的疫苗。

Vaccines that contain thiomersal include those against diphtheria , tetanus and pertussis ( DTP ), hepatitis B , Haemophilus influenzae type b ( Hib ), rabies , influenza and meningococcal diseases .

在以前的研究中，人白细胞介素4（hIL4）与白喉毒素（DT）的融合蛋白（DT4H）被构建，且它对某些肿瘤细胞系的高毒性得到了证明。

Previously , a fusion protein ( DT4H ) was constructed with human interleukin 4 ( hIL4 ) and diphtherial toxin ( DT ) .

结论应用Stainer培养基与TFF系统可获得符合我国现行规程要求的精制白喉类毒素。

Conclusions The results indicate that application of Stainer medium and TFF system can obtain purified diphtheria toxoid which meets the Requirements for Biologics of China .

WHOW发言人PaulGarwood表示，联合国机构和海地政府下周将为数千名5岁以下儿童接种麻疹，破伤风和白喉疫苗。

WHO spokesman Paul Garwood says U.N. agencies and the Haitian government will conduct a campaign next week to hundreds of thousands of children under age five against measles , tetanus and diphtheria .

EWS-FLI1介导白喉毒素表达对尤文肉瘤移植瘤杀伤作用研究

Killing Effect of Expression of the Diphtheria Toxin a Chain Gene Regulated by the EWS-FLI 1 Fusion Gene on Ewings Sarcoma

方法采用随机抽样方法抽取调查点和被测人群，用间接血凝试验（IHA）检测抗白喉毒素抗体，结果分析采用χ2检验和F检验。

Methods The investigation site and the samples from teen-age people were selected with the random sampling method . By using the indirect hemagglutination assay ( IHA ) method , the antibodies against diphtheria toxoid were examined . The results were analyzed with χ ~ 2 test and F test .

结果1、对重组载体的酶切鉴定和测序结果证实，在pS2-DTA中EWS-FLI-1特异性结合序列（ACCGGAAGT）位于白喉毒素A链基因上游。

Results 1 . The result of restriction enzyme digest and gene sequence showed that the EWS-FLI-1 binding sequence ( ACCGGAAGT ) lay at the upper stream of diphtheria toxin A fragment .