淀粉样蛋白前体

神经传递与β-淀粉样蛋白前体的加工调控

Neurotransmission and regulation of amyloid protein precursor processing

用Western印迹和斑点印迹法分析GM1与重组β－淀粉样蛋白前体的亲和性。

The affinity of GM1 and recombinant secretory APP was analyzed by Western blot and dot blot .

家族性Alzheimer病淀粉样蛋白前体基因第16、17外显子的突变分析

A study on mutation of 16 and 17 exon of APP gene in familial Alzheimer 's disease

神经节苷脂GM1对阿尔采默病β-淀粉样蛋白前体代谢的影响

Effect of ganglioside GM 1 on the metabolism of Alzheimer amyloid β protein precursor

目的研究阿尔茨海默病（AD）动物模型-APP/PS1转基因鼠大脑内游离锌离子和β淀粉样蛋白前体蛋白（APP）在老年斑内的分布。

Objective To investigate the distribution of free zinc ions and β - amyloid precursor protein ( APP ) in the senile plaques of an Alzheimers diseased animal model , the APP / PS1 transgenic mouse .

他们的实验证明，AD脑部存在由于GA缺失造成移码突变的β淀粉样蛋白前体和泛素－B，并推测这种移码突变是AD病理的重要起始因子。

They proved mutants of β - amyloid precursor protein and ubiquitin-B , caused by GA deletion and subsequent frameshift mutation , existed in AD brain and surmised that transcript mutation was a critical factor for initiating neuropathology in nonfamilial AD.

目的研究外源性神经节苷脂GM1干扰细胞β－淀粉样蛋白前体代谢的作用，探讨GM1与阿尔采默病特征性病理变化老年斑和其他淀粉样病变形成的关系。

Objective To study the effect of GM1 ganglioside interfering the metabolism of amyloid β protein precursor ( APP ) on cells for exploring the relationship between GM1 and development of Alzheimer senile plaques and the other amyloidoses .

它们改变了这个酶切割淀粉样蛋白前体的方式。

They alter the way it cleaves amyloid precursor protein .

β淀粉样蛋白前体基因表达的研究进展

Research advances in amyloid β protein precursor gene expression

雌激素抑制淀粉样蛋白前体羧基端片段在雌性去势大鼠海马和脑皮质的表达

Estrogen inhibition on the expression of amyloid precursor protein C-terminal in ovariectomized female rat hippocampus and cortex

老年性痴呆病人载脂蛋白E基因多态性与淀粉样β蛋白前体表达的关系

A correlation between apolipoprotein E polymorphism and β amyloid precursor protein in patients with Alzheimer disease

雌激素组各观察部位淀粉样β蛋白前体蛋白β位点裂解酶表达阳性细胞数和血液雌激素含量与对照组接近（P均>0.05）。

Estrogen group and control group did not significantly differ in the number of BACE positive neurons in each encephalic region observed and the content of estrogen ( P > 0.05 ) .

淀粉样β蛋白前体蛋白17肽对神经保护的作用及其机制

Neuroprotective effect of amyloid - beta protein precursor 17 peptide and its mechanism

淀粉样β蛋白前体转基因小鼠与正常小鼠脑蛋白质组蛋白质表达差异

Difference of proteomic protein expression in brains between amyloid protein precusor transgenic mice and normal mice

背景：脑中雌激素可调节淀粉样β蛋白前体蛋白的代谢与β淀粉样蛋白的产生。

BACKGROUND : Estrogen has a role in regulating the metabolism of beta-amyloid precursor protein and the production of beta-amyloid protein .

小鼠糖尿病脑病神经元退变的机制及淀粉样β蛋白前体17肽的作用

The mechanism of neuron degeneration of diabetic encephalopathy and the effect of amyloid - β protein precursor 17 peptide in diabetic mice

结论：促进神经营养因子的表达是淀粉样β蛋白前体蛋白17肽神经元保护作用的有效机制之一；

CONCLUSION : One of the effective mechanism on the expression of NTF is the protective effect of amyloid - β protein precursor 17 peptide on neurons .

目的：以蛋白质组学技术研究淀粉样β蛋白前体转基因小鼠与正常小鼠脑蛋白质表达差异，从蛋白质分子水平探索老年性痴呆发病机制。

AIM : To study the difference of protein expression in brain with the proteomic technique between amyloid protein precusor ( APP ) transgenic mice and normal mice , and investigate the molecular mechanisms of Alzheimer disease .

了解雌激素与淀粉样β蛋白前体蛋白代谢以及关键酶淀粉样β蛋白前体蛋白β位点裂解酶的关系，对研究轻度认知障碍、阿尔茨海默病的发病原因具有重要作用。

It is important for studies on etiological factors of mild cognitive impairment and Alzheimer 's disease to understand the relationship of estrogen with the metabolism of beta - amyloid precursor protein and beta-amyloid precursor protein cleaving enzyme ( BACE ) .

氯化铝对大鼠脑组织胶质原酸性纤维蛋白和淀粉样β-蛋白前体基因表达的影响

Effects of aluminum chloride on amyloid β protein precursor and glial fibrillary acidic protein expression in rat cortex 1

目的：研究神经节苷脂GM1对β淀粉样蛋白（Aβ）分泌和β淀粉样蛋白前体（APP）基因转录水平的影响，探讨GM1在阿尔茨海默病Aβ生成过程中的作用机制。

Objective : To study the effects of ganglioside GM1 on the secretion of amyloid β protein ( A β) and the transcription of amyloid β protein precursor ( APP ) gene , and to discuss the mechanism of GM1 in the generation of A β in Alzheimer disease .

背景：淀粉样β蛋白沉积是引致阿尔茨海默病的重要原因，淀粉样β蛋白前体基因过度表达或某部分发生突变，可能与阿尔茨海默病的发生有关。

BACKGROUND : Deposition of beta-amyloid protein is the main cause of Alzheimer disease . Overexpression of β - amyloid precursor protein gene (β APP-gene ) or mutation of it at certain part can be related with the attack of Alzheimer disease .

神经节苷脂GM1促进Alzheimer病长β-淀粉样蛋白（βA4（42））分泌以及干扰β-淀粉样蛋白前体（APP）代谢

GM1 Ganglioside Increases Secretion of Long Amyloid β - Protein and Interferes Metabolism of Amyloid β - Protein Precursor ( APP ) in Alzheimer 's Disease