水飞蓟素

水飞蓟素对肾小管间质纤维化大鼠核转录因子-κB和细胞间黏附分子-1表达的影响

Effects of Silymarin on Expressions of Nuclear Factor Kappa B and Intercellular Adhesion Molecule-1 in Renal Tissue of Rats with Tubulointerstitial Fibrosis

由于水飞蓟素在水中几乎不溶，本文首先采用溶剂法，以PVPK30为载体，制备了水飞蓟素固体分散体，以提高水飞蓟素的水溶性。

Due to aqueous insolubility of silymarin , the solid dispersion was prepared by the solvent method using PVP K30 as the hydrophilic carrier matrix .

HPLC法测定水飞蓟素胶囊中水飞蓟素异构体的含量

Determination of Six Isomers of Silibin in Silymarin Capsules by HPLC

建立水飞蓟素中5种活性成份的HPLC方法，绘制各成份的释放曲线，计算各曲线间相似因子（f2）；

An HPLC method was employed to determine the five active components of silymarin , based on which , the release profiles of the components were drawn and similarity factor f2 values between each two of the profiles were calculated .

鸭肝炎病毒（DHV）刺激雏鸭增重和发育及水飞蓟素对其影响的研究

Study on the Potential of Duck Hepatitis Virus ( DHV - ⅰ) to Stimulate the Body Weight Gain and Body Length Gain and the Effects of Silymarin on Them in Younger Duck

结果水飞蓟素磷脂复合物0.28、0.84g/Kgbw剂量能降低ALT、AST活性，减轻肝脏病理损伤（P<0.05）。

Result The silymarin phosphatidylcholine complex can reduce the active of ALT and AST at the dosage of 0.28 、 0.84g/kg BW , and it can reduce the pathological damage on liver ( P < 0.05 ) .

结论水飞蓟素磷脂复合物对CCI4造成的急性肝损伤有明显的保护作用。

Conclusion The protective effect of silymarin phosphatidylcholine complex aganist acute liver damage by carbon tetrachloride was very obvious .

考察影响分散片崩解时间的因素，在此试验结果基础上，以90min水飞蓟素在水中累积溶出百分率为评价指标，运用四因素三水平正交试验设计筛选处方，确定其最佳用量；

Based on the results of single-factor tests about the influence factors on disintegration time of dispersible tablets , the amounts range of silymarin and excipients were set .

在欧洲，水飞蓟素曾广泛用于临床的肝炎治疗。

In Europe , silymarin had been used to treat hepatitis .

水飞蓟素对肝纤维化小鼠的保护作用及机制探讨

The effect and mechanism of Silymarin on liver fibrosis in mice

水飞蓟素磷脂酰胆碱复合物对实验性肝损伤的保护作用

The protective effect of silymarin phosphatidylcholine complex on liver damage in mice

水飞蓟素对大鼠非酒精性脂肪性肝炎的防治作用及机制

Effects and mechanism of silymarin on nonalcoholic steatohepatitis in rat

小分子化合物水飞蓟素和酮康唑对肿瘤靶点作用机制的研究

The Mechanism of Cancer Targeting Effect of Small Molecules Silymarin and Ketoconazole

水飞蓟素与左卡尼汀对非酒精性脂肪性肝病的临床研究

Clinical effect of silymarin combined with levocarnitine on non-alcoholic fatty liver disease

水飞蓟素自乳化给药系统处方设计及溶出度评价

Formulation and Dissolution Evaluation Design of Self-emulsifying Drug Delivery System for Silymarin

水飞蓟素前体脂质体的制备和大鼠药代动力学的研究

Preparation of silymarin proliposomes and its pharmacokinetics in rats

水飞蓟素固体分散体中总黄酮的测定

Quantitation of flavonoids in silymarin loaded solid dispersion system

水飞蓟素中活性组分同步缓释给药系统的研制

Development of synchronized and sustained release system of silymarin

水飞蓟素固体脂质纳米粒载药机制的研究

Drug-loaded mechanism of solid lipid nanoparticles loading with silymarin

水飞蓟素微乳大鼠在体小肠吸收的动力学

The absorption kinetics of silymarin microemulsion in rat intestine

常温超高压提取水飞蓟素的研究

The High Pressure Extraction of Silymarin at Room Temperature

进行了水飞蓟素磷脂复合物家兔体内的生物利用度研究。

The oral bioavailability of silymarin-phosphatidylcholine complex and silymarin in rabbits was studied .

水飞蓟素药学研究进展

Advances in the pharmaceutical research on the Silymarin

以水飞蓟素、柚皮苷、葛根素和没食子酸为靶标分子。

Silymarin , Naringin , Puerarin and Gallic Acid were used as target molecules .

结论该方法简便、可靠，适用水飞蓟素滴丸的质量控制。

CONCLUSION This method is simple and reliable for the assay of the preparation .

水飞蓟素对乳腺癌细胞系的作用及其机制研究

Inhibitory effect of silymarin on different breast cancer cell lines and associated molecular mechanism

水飞蓟素抗肿瘤作用及其机制研究进展

Progress in antineoplastic effects and mechanisms of silymarin

水飞蓟素-两亲性壳聚糖胶束的制备及其大鼠在体肠吸收

Preparation of silymarin-loaded amphiphilic chitosan micelle and its in situ absorption in rat intestine

水飞蓟素对脑缺血性损伤的影响

The Effect of Sematron on Cerebral Ischemia Damage

微波辅助萃取水飞蓟素的动力学机理

Kinetic mechanisms for silymarin by microwave-assisted extraction