喜树碱

P53基因在羟基喜树碱致大肠肿瘤细胞凋亡中的作用

The Influence of P53 Gene in Hydroxyl Camptothecin Induced Apoptosis of Colorectal Cancer

结果悬浮培养细胞在MS培养基中细胞生长良好，细胞分散性和喜树碱积累优于在其他培养基中。

Results Suspension culture cells grew well in MS medium and cell homogeneity and camptothecin content were superior to those in other media .

但浅表性膀胱癌术后复发率仍很高，术后为预防复发多配合膀胱灌注治疗，目前常用的药物为丝裂霉素C、羟基喜树碱、卡介苗等。

But the recurrence rate of superficial bladder cancer after surgery is still high .

自然光和热对闭环（E环）喜树碱稳定性的影响

Effection of Nature Light and Heat for Stability of Close Loop form of CPT

HPLC法测定羟基喜树碱人血清白蛋白纳米粒中的药物含量

Determination of 10-hydroxycamptothecin in human serum albumin nanoparticles by HPLC

羟喜树碱pH敏感阳离子纳米脂质体的制备

Preparation of Hydroxycamptothecin PH-sensitive Cationic Nanoliposomes

HPLC法测定羟喜树碱注射液中有关物质

HPLC determination of related substances in hydroxycamptothecine injection

芫花酯甲的化学结构与喜树碱类完全不同，属于新结构类型的DNA拓扑异构酶I抑制剂。

Yuanhuacine is another kind of Topo I inhibitor with completely different structure compared with known camptothecin and its analogs .

羟基喜树碱对KB细胞克隆形成的抑制及对DNA的损伤

Inhibitory effect of hydroxycamptothecin on colony formation of KB cells and DNA damage

热疗合并羟基喜树碱对荷Lewis肺癌小鼠的作用

The Effect of Hyperthemia with Hydroxycamptothecine on Mice with Lewis Lung Carcinoma

运用羟基喜树碱与5-FU治疗恶性胸腔积液的对照观察

Control observation on HCPT and 5-FU therapy for malign pleural effusion

载羟基喜树碱微泡+超声组与其他各组间的差异具有显著性意义（P0.05）。

The result of HCPT-loaded microbubbles plus ultrasound group was significantly different with other groups ( P 0.05 ) .

10-羟基喜树碱治疗胃肠道肿瘤近期疗效及安全性的Meta分析

Short-Term Efficacy and Safety of 10-Hydroxy-camptothecin Chemotherapy on Gastrointestinal Carcinoma : A Meta-analysis

结果在模拟生理pH下24h受脂质体包裹的羟喜树碱的闭环率仍大于90%。

RESULTS More than 90 % HCPT in liposomes remained its lactone form in stimulated physiological environment for 24 h.

RP-HPLC法测定注射用羟喜树碱脂质体含量

Determination of Hydroxycamptothecin Liposome for Injection by HPLC

NFκB在羟基喜树碱诱导乳腺癌细胞凋亡和细胞周期阻滞中的作用机制研究

Roles of NF κ B in G 1 / S Cell Cycle Checkpoint and Apoptosis Induced by HCPT in Human Breast Carcinoma Cells

经TLC，IR，NMR，MS分析证实为喜树碱（camptothecin），毒性试验证明是喜树叶的主要有毒成分。

The toxicity test proved that Camptothecin is the main toxic element in the leaves of Camptotheca acuminata .

结肠癌羟基喜树碱耐药细胞SW1116/HCPT酵母双杂交cDNA文库的构建和鉴定

Construction and characterization of yeast two-hybrid cDNA library of hydroxycamptothecin-resistant human colon cancer cell line SW1116 / HCPT in yeast cells

羟基喜树碱合用PF方案治疗食管癌术后肺转移68例临床观察

Clinical observation of 68 cases of esophageal carcinoma postoperative pulmonary metastasis with HCPT and PF combination therapy

方法建立了采用RP-HPLC法测定兔血浆和组织中羟基喜树碱浓度的方法。

Methods RP-HPLC was used to determine the concentration of HCPT in different tissues and plasma of rabbits .

为了研究喜树碱的药理性质，用比导数荧光光谱和紫外吸收光谱法分析了喜树碱在不同pH介质中的形态分布。

The distribution of camptothecin and its ring opened form was studied by first derivative ratio spectrum of UV vis absorption and fluorescence spectrometry in different pH aqueous buffer solutions .

目的：预测羟基喜树碱（OPT）的抗癌谱，指导临床用药。

Objective The anti carcinoma pattern of hydroxy camptothecine ( OPT ) is estimated and guided to clinical medication .

背景与目的：伊立替康（CPT-11）是喜树碱类抗癌药物，为DNA拓扑异构酶Ⅰ抑制剂。

Background and purpose : Irinotecan ( CPT-11 ) is a derivative of camptothecin , an inhibitor of DNA topoisomerase I.

结论：羟基喜树碱为主的化疗方案有明显降低瘤负荷及抑制巨噬细胞分泌TNFα的作用。

Conclusions : The chemotherapy of hydroxycamptothecin combined with calcium folinate and 5-fluorouracil can dramatically reduce the neoplasia and inhibit the secretion of TNF α of macrophagocyte .

结论拓喜（羟基喜树碱）除了对小鼠艾氏腹水癌移植瘤抑制作用有明显的时辰差异外，对WBC的影响也有时辰的变化。

Conclusion The effect and WBC change of hydroxy camptothecin on chronotherapy in EAC mice had chrono-effect and changes .

羟基喜树碱联合ELF方案治疗晚期胃癌的临床观察

Hydroxyl Camptothecin , Leucovorin , Fluorouracil and Etoposide Combined Regimen in the Treatment of Advanced Gastric Adenocarcinoma

疏水性抗癌药物喜树碱（CPT）为模型药物。

The anticancer drug , camptothecin ( CPT ) was used as a hydrophobic model anticancer drug .

结果羟基喜树碱以剂量依赖的方式抑制BEL-7402细胞的生长；

Results Hydroxyl camptothecinum could inhibit the growth of hepatoma cells in a dose-dependent manner .

喜树碱（CAM）诱导人类急性早幼粒细胞白血病细胞株（HL-60）细胞，以高渗磷酸-柠檬酸盐缓冲液（PC）处理，并同时用线性放大和对数放大进行DNA含量分析。

HL 60 cells induced by camptothecin were treated with hypertonic phosphate citric acid buffer , and the DNA content was detected by using linear and logarithmic amplifier simultaneously .

10-羟基喜树碱在0.30-4.00μg范围内线性关系良好，其低、中、高3个量的平均加样回收率分别为99.87%，99.98%，100.4%；RSD分别为0.32%，0.19%，0.34%。

The average recoveries of 10-hydroxycamptothecin were 99.87 % , 99.98 % and 100.4 % with corresponding RSD of 0.32 % , 0.19 % and 0.34 % .