受体家族

Fas受体和它的天然配体FasL同属肿瘤坏死因子／神经生长因子（TNF/NGF）受体家族，Fas可表达于多种正常组织，而FasL主要表达于激活的免疫细胞。

Fas / FasL belong to the nerve growth factor / tumor necrosis factor receptor superfamily . Many kinds of tissues express Fas , but FasL is mainly expressed in activated lymphocytes .

PR（progesteronereceptor），是核受体家族中的重要转录因子。

HPR ( human progesterone receptor ), which is the important nucleus transcriptional factor .

EGF受体家族在不同胰腺癌细胞表达量不同。

EGFR family expressed in pancreatic cancer cell lines with different levels .

死亡配体与细胞表面TNF受体家族结合是细胞凋亡信号下传的重要途径。

Signaling via cell-surface receptors of the tumor necrosis factor receptor family is considered an important trigger mechanism to activate the cell 's apoptosis .

HER2/neu作为表皮生长因子受体家族的一员，在过表达的情况下能够激活Ras/Raf/MEK/MAPK通路，但是否通过此通路对乳腺癌细胞内p53表达产生影响，进而影响细胞的增殖和凋亡，目前亦未见报道。

As the analogues of human epidermal growth factor recptor , HER2 / neu overexpression can activate Ras / Raf / MEK / MAPK pathway .

EGF受体家族成员通过配体形成同源或异源二聚体，活化胞内酪氨酸激酶，从而激活信号转导通路。

EGFR family members binding with ligands to form homo-dimers or hetero-dimers activate intracellular tyrosine kinase , which further activate cysto-signal transduction pathway .

作为核受体家族的成员之一，AR在结合了雄激素后，转位到核内，与靶基因启动子结合，发挥转录因子的活性。

Similar to other nuclear receptors , upon binding to androgen , AR is translocated into nucleus , binds to the promoters , and mediates transcription of target genes .

生物信息学分析发现，该基因编码699个氨基酸，属于蓝光受体家族，与其他植物中CRY蛋白具有较高的同源性。

The results of bioinformatics analysis show that it encodes 699 amino acids and belongs to blue light receptor family , and showed high identity with other CRY in plant .

鸡Edg受体家族基因的克隆及其在胚胎发育早期中的表达分析

Cloning and Expression Analysis of Edg Family Receptors during Early Chick Development

多种类固醇/甲状腺受体家族的成员参与了CRH基因的表达调控，例如糖皮质激素受体，雌激素受体和雄激素受体等。

Several members of steroid / thyroid receptor family have been suggested in the regulation of CRH gene expression .

研究结果提示，GnRH－R属于G蛋白偶联受体家族，由包含7次跨膜结构域的单一多肽链构成，编码327或328位氨基酸。

GnRH-R belongs to the G protein coupled receptor family , and it is consisted of a polypeptide chain containing 7 transmembrane domains . The GnRH-R encodes 327 / 328 amino acids .

整合素是一类细胞膜表面糖蛋白受体家族分子，主要介导细胞与细胞外基质（Extracellularmatrix，ECM）以及细胞与细胞之间的黏附，在调节细胞生长、分化、增殖等方面起着重要作用。

Integrins are a family of glycoprotein receptor on cell surface and participate in cell adhesion with extracellular matrix ( ECM ), playing an important role in regulating cell growth , differentiation and proliferation .

PPAR激动剂，是细胞核激素受体家族转录因子的一个成员，被广泛用来治疗II型糖尿病，而且相对无毒。

Agonists of PPAR , a member of the nuclear hormone receptor family of transcription factors , are widely used in the treatment of type II diabetes and are relatively non-toxic .

Toll样受体家族（TLRs）识别抗原相关的分子模式（PAMPs）后激发先天性免疫反应。

The family of Toll-like receptors ( TLRs ) initiates an innate immune response after recognition of pathogen-associated molecular patterns ( PAMPs ) .

轴突导向因子netrin-1及其受体家族在角膜血管新生中的导向作用

Netrin and Receptors in Guidance Corneal Angiogenesis

FLT3、c-KIT是Ⅲ型酪氨酸激酶受体家族中的重要成员，其配体均为干细胞因子。

FLT3 、 c-KIT are the important members of the family receptor tyrosine kinase , the ligands are both stem cell factor .

生长抑素受体家族介导的子宫内膜癌细胞系HEC-1A的生长抑制作用

The growth-inhibitory effect of endometrial carcinoma cell line HEC-1A induced by somatostatin receptor family

已有研究表明，病菌侵入后，其胞内的内毒素释放出来首先与乳腺上皮细胞膜表面的的TOLL样受体家族结合，进而激活下游通路，导致促炎症因子的释放。

There has been shown that the endotoxin firstly release from its intracellular after bacteria invasion and then bind with the Toll-like receptor family of the mammary epithelial cell membrane , activate downstream pathways , result in the proinflammatory cytokine release .

与GNT作用的是早幼粒细胞白血病锌指蛋白（PLZF），属于视黄酸受体家族的一种转录因子。

Promyelocytic leukaemia zinc finger protein ( PLZF ) is a transcriptional factor and a member of retinoic acid receptor family .

最近的研究工作表明，睾丸的分化受到胰岛素受体家族基因的调控，正常情况下SRY需通过两个不同的核运输途径使足够剂量的SRY蛋白进入细胞核调控性腺分化过程。

Recent studies show that testis differentiation requires insulin receptor family function in mice . SRY normally requires two distinct NLS-dependent nuclear import pathways to reach sufficient levels in the nucleus for gonadal differentiation .

表达上调的基因主要包括肿瘤坏死因子配体和受体家族、半胱氨酸家族、Bcl-2家族、DNA损伤检测和P53途径和细胞分裂周期蛋白和激酶等；

The up-regulated genes mainly belonged to the tumor necrosis factor ( TNF ) ligand and receptor superfamily , Caspase family , Bcl-2 family , DNA damage checkpoint / P53 and ATM pathways , cell division cycle proteins and kinases , cyclin , cyclin - dependent kinases and inhibitors .

背景和目的原癌基因HER-2属于表皮生长因子受体家族成员，在20%~30%的卵巢癌中过表达，参与了卵巢癌的发生和发展。

Background and Objective HER-2 is a member of the epidermal growth factor receptor family , and its overexpression in ovarian cancer has been reported to be approximately 20 ~ 30 % , which is involved in the carcinogenesis and progression of ovarian cancer .

研究表明，Eph受体家族整合信号是调节细胞迁移与侵袭的关键点，Eph受体家族有望成为监测及治疗白血病髓外浸润的突破口。

It has been shown that integration signaling of Eph receptor family is the key point for regulating migration and invasion , and Eph receptor family is expected to become the breakthrough for the monitoring and treatment of extramedullary infiltration .

上皮生长因子受体家族与肺癌的分子靶向治疗

Epidermal growth factor receptor family and molecular targeting therapy of lung cancer

一个新的信号受体家族&Toll/IL1R家族的研究进展

A New Signal Receptor Family & A Review of the Current Progress of Toll / IL-1R Family

目的：检测食管癌组织中表皮生长因子受体家族的表达水平，了解其与食管癌临床病理各指标及预后的关系。

Objective : To investigate the expression of EGFR family in esophageal carcinoma and its relation with clinical significance .

在肺癌淋巴转移过程中，血管内皮生长因子及其受体家族发挥了重要的作用。

Vascular endothelial growth factors ( VEGFs ) and their receptors ( VEGFRs ) play important roles during this processes of lymphatic metastasis .

对视黄酸受体家族、视黄酸受体γ基因和视黄酸受体γ同工型基因的结构以及视黄酸受体γ的表达与调控等方面进行了综述。

This review introduced retinoic acid receptor families , the structure of retinoic acid receptor gamma gene and its isomorphic gene , expression and regulation of retinoic acid receptor gamma gene .

核受体家族的经典作用机制是在其配基存在下结合在靶基因的应答元件上，从而在转录水平上调节基因的表达。

The classical mechanism for nuclear receptors to regulate gene expression is to bind the hormone response element ( HRE ) on the target gene in the presence of their ligands .

ERβ属于核受体超家族成员。

ER β is a member of the nuclear receptor super family .