卡马西平

HPLC法测定人唾液中卡马西平浓度及其药代动力学

Determination of carbamazepine concentration in human saliva by HPLC and its pharmacokinetic study

卡马西平对青霉素点燃癫痫大鼠脑内GABAB受体蛋白表达的影响

The influences of carbamazepine on GABA_B-R protein expression in brain of PNC-kindled convulsant rats

运用Excel建立卡马西平TDM室内质控方法

The internal quality control method of TDM for carbamazepine by Excel

HPLC法同时测定人血清中卡马西平、环氧化卡马西平和苯妥英

HPLC Simultaneous Determination of Carbamazepine , Carbamazepine - 10 , 11 - epoxide , Phenytoin in Human Serum

RP-HPLC同时测定人血清中苯巴比妥、苯妥英、卡马西平的浓度

Determination of Phenobarbital , Phenytoin and Carbamazepine in Serum by RP-HPLC

HPLC法和FPIA法检测卡马西平血药体积百分比的比较研究

Comparison of HPLC and FPIA Method in Determination of Carbamazepine in Human Serum

且卡马西平自身不会使大鼠产生CPP。

Carb itself did not induce CPP in rats .

卡马西平能提高脑脊液及血浆中5-HT和5-HIAA含量。

AEDs can raise concentrations of 5-HT / 5-HIAA in CSF .

结论：应用HPLC法对卡马西平进行TDM，可以用手指血代替静脉血。

CONCLUSIONS : The finger prick blood can be used for TDM of CBZ by HPLC instead of venous blood .

LC-MS测定大鼠脑微血管内皮细胞中卡马西平的含量

Determination of Carbamazepine in the Brain Capillary Endothelial Cells of the Rat by LC-MS

目的：本实验考察了不同时间冰冻储存（$C20℃）[1]对血清中苯妥英钠、卡马西平HPLC色谱图和测定结果的影响。

Objective : To study the HPLC chromatogram and the concentrations of phenytoin and carbamazepine in human plasma after freezing store (– 20 ℃) for different time .

卡马西平与TRH抗癫痫作用相互关系的研究

A study on the relationship of antiepileptic effect between carbamazepine and thyrotropin releasing hormone

目的：建立HPLC法同时测定血清苯妥英（PHT）与卡马西平（CBZ）浓度。

OBJECTIVE : To develop an HPLC method for quantitative determination of phenytoin and carbamazepine in blood serum .

在不同时间点采集小鼠血样和脑组织样品，经过处理后通过HPLC测定卡马西平血药浓度和脑组织浓度，绘制药-时曲线图。

Blood and brain tissue samples were collected at different time . After the samples were pretreated . they were detected by HPLC , and the concentration-time curves were obtained .

目的：本法建立了高效液相色谱法（HPLC）同时测定抗癫痫药苯巴比妥（PB）、苯妥英钠（DPH）及卡马西平（CBZ）的血药浓度。

Objective : To establish the method to determine some anti-epilepsy drugs PB , DPH and CBZ concentration in the blood by HPLC .

结果：经过不同时间冰冻储存的血清，其HPLC色谱图基本上没有发生变化，血清中苯妥英钠、卡马西平浓度5次测定结果之间无显著性差异。

Results : The HPLC chromatogram were almost the same and there were no notable difference between the 5 determined concentrations of phenytoin and carbamazepine in human plasma after freezing store for different time .

目的：观察神经妥乐平和卡马西平对带状疱疹后神经痛（PHN）的疗效。

Objective : To observe the efficacy of neurotropin and carbamazepine in the treatment of post herpetic neuralgia .

目的探讨卡马西平与促甲状腺素释放激素（TRH）抗癫痫作用的相互关系。

Objective To investigate the relationship of antiepileptic effect between carbamazepine ( CBZ ) and thyrotropin releasing hormore ( TRH ) .

目的探讨丙戊酸钠（VPA）与卡马西平（CBZ）对脑电活动的影响。

Objective To explore the effect of VPA and CBZ ( valproate and carbamazepine ) on the electroencephaletro activity .

目的：建立卡马西平（CBZ）诱导的骨髓抑制大鼠模型。

Aim : To establish the model of rat bone marrow inhibition induced by carbamazepine tablets ( CBZ ) .

目的探讨卡马西平（CBZ）对脑电图背景频率的影响。

Objective To investigate the influence of carbamazepine ( CBZ ) on background frequency of eletroencephalogram ( EEG ) .

目的：探讨丙戊酸钠（VPA）和卡马西平（CBZ）对脑电图的影响。

Objectives : To investigate the effect of valproic acid ( VPA ) and carbamazepine ( CBZ ) upon electroencephalogram .

目的：评价国产卡马西平（CBZ）在躁狂症临床治疗中的实用性。

Objective : To evaluate the practicality of carbamazepine ( CBZ ) made in China in the treatment of mania .

目的探讨卡马西平（CBZ）对癫痫患儿甲状腺激素水平的影响。

Objective To evaluate the effect of carbamazepine ( CBZ ) monotherapy on serum levels of thyroid hormones in epileptic children .

目的研究唾液取样方法和昼夜生物节律对唾液中卡马西平（CBZ）浓度的影响。

AIM To investigate the effect of collection methods and diurnal rhythm on the carbamazepine ( CBZ ) level in saliva .

口服卡马西平及三叉神经撕脱术使TSEP图形发生变化。

Result indicated that Carbamazepine and trigeminal nerve avulsion made TSEP graph change .

用RP－HPLC法测定人血清中卡马西平（CBZ）及活性代谢产物卡马西平10，11－环氧化物（CBZ－E）的含量。

A RP-HPLC method for the simultaneous determination of carbamazepine ( CBZ ) and carbamazepine-10 , 11-epoxide ( CBZ-E ) in serum was described .

卡马西平（Carbamazepine，CBZ）是杂环类（亚氨基二苯乙烯）广谱抗癫痫药，具有抗外周神经痛、抗躁狂抑郁、抗利尿及抗心律失常等作用。

Carbamazepine is a heterocyclic ( iminodiacetic styrene ) broad-spectrum antiepileptic drug , and has the role of anti-peripheral nerve pain , anti-manic-depressive , anti-diuretic and antiarrhythmic .

目的：探讨中药复康片对卡马西平（CBZ）致大鼠肌纤维损害的保护效果。

Aim : To investigate the effect of carbamazepine on motor unit potential ( MUP ) of rectus femoris of rats and the protective effect of Fukang tablets .

报告25例单用苯妥英钠（PHT）和12例PHT与卡马西平（CBZ）联用引起中毒的癫痫患者的血药浓度。

He serum phenytoin concentration was reported in epileptic patients who were poisonedwithphenytoin ( PHT ) monotherapy in 25 cases and with phenytoin combined with carbamazepine ( CBZ ) in l2 cases .