苯妥英钠

灌胃惊厥大鼠苯妥英钠（PHT，0.154g·kg-1·d）7天，并于每次给药后用上述相同参数电刺激皮层，建立耐苯妥英钠大鼠惊厥模型。

Then , ig PHT ( 0.154g · kg-1 · d ) for 7 days and stimulating the cortex of rats in the same parameter as above-mentioned after each administration PHT , established phenytoin-resistant convulsive rats model .

苯妥英钠耐药鼠神经元保护基因的表达

Neuron protection genes expression in PHT resistant epileptic rats with cDNA microarray

关附甲素对实验性心律失常的作用苯妥英钠与前列腺素E2联合应用抗实验性哇巴因心律失常的研究

Effects of combination of diphenylhydantoin and prostaglandin e_2 on ouabain-induced arrhythmias

采用HPLC法测定本品中磷苯妥英钠及有关物质的含量。

P 2000 , the assay of fosphenytoin sodium and related substances was determined by HPLC .

苯妥英钠对实验性癫痫脑cAMP、cGMP的影响研究

Effect of phenytoin on cAMP or cGMP of brain tissue in experimental epilepsy rats

TCD可明显减慢苯妥英钠在大鼠体内的代谢过程。

TCD can significantly decrease phenytoin metabolism in rats .

最佳特殊效果奖，最佳音效奖，最佳配乐奖，等等。①目的探讨癫痫病人应用苯妥英钠（PH）疗的最佳有效血药浓度。

Best Special Effects , Best Sound , Best Musical Score . etc. Objective To find out the best and effective serum concentration of DPH for patients with epilepsy .

目的：本实验考察了不同时间冰冻储存（$C20℃）[1]对血清中苯妥英钠、卡马西平HPLC色谱图和测定结果的影响。

Objective : To study the HPLC chromatogram and the concentrations of phenytoin and carbamazepine in human plasma after freezing store (– 20 ℃) for different time .

苯妥英钠组测试成绩提高较慢（P<0.05），与NS组比较无明显差异。

The performance record of TPM group has been elevated slowly ( P > 0.05 ) , and is worse than NS group .

对11例癫痫病人的苯妥英钠（DPH）之药物代谢动力学参数进行了研究。

Pharmacokinetic parameters of phenytoin were determined in 11 epileptic Patients .

苯妥英钠C-T曲线的双峰现象

The double phenomena of phenytoin sodium in C - t graph

目的：本法建立了高效液相色谱法（HPLC）同时测定抗癫痫药苯巴比妥（PB）、苯妥英钠（DPH）及卡马西平（CBZ）的血药浓度。

Objective : To establish the method to determine some anti-epilepsy drugs PB , DPH and CBZ concentration in the blood by HPLC .

考察了大鼠口服苯妥英锌或苯妥英钠15mg／（kg·d）45d对血脂的影响。

Rats were treated with phenytoin zinc or phenytoin sodium 15mg / ( kg . d ) for 45d .

目的探讨苯妥英钠（PHT）对癫痫儿认知功能的影响及叶酸制剂对其认知功能障碍的改善作用。

Objectives To investigate the improvement effect of folic acid on phenytoin-induced cognitive dysfunction in epileptic children .

F检验和t检验结果显示高精度散射光度滴定法测定苯妥英钠，在精密度和准确度方面与重量法、电位滴定法测定结果均无显著差异（α>0.05）。

The results of F test and t test demonstrate that the precision and the accuracy of highly-accurate nephelometric titrimetry are comparable to those of gravimetry and potentiometric titrimetry (α > 0 05 ) .

结果：经过不同时间冰冻储存的血清，其HPLC色谱图基本上没有发生变化，血清中苯妥英钠、卡马西平浓度5次测定结果之间无显著性差异。

Results : The HPLC chromatogram were almost the same and there were no notable difference between the 5 determined concentrations of phenytoin and carbamazepine in human plasma after freezing store for different time .

背景：苯妥英钠（PHT）在蛛网膜下腔出血后被广泛地应用，经常应用数周或数月。

OBJECTIVE : Phenytoin ( PHT ) is widely administered after subarachnoid hemorrhage , often for several weeks or months .

方法：采用稽延症状自评量表，SAS焦虑自评量表，不良反应监测表，苯妥英钠血药浓度监测等手段，对我所在院病人进行临床观察和实验研究。

Methods : Through the self-evaluate list of protracted symptom ; SAS ; drug reactions monitor list and blood solubility monitor , to observe and investigate the patients in our center .

材料：苯妥英钠购自Sigma公司，人精液标本取自近半年内未接触过理化诱变因子的健康成年男性。

MATERIALS : Phenytoin sodium was purchased from Sigma Company . The human sperms were collected from the healthy males who had not contacted with any physicochemical mutagen within recent 6 months .

目的探索性应用苯妥英钠（PHT）、苯巴比妥钠（PB）诱导建立难治性癫疒间动物模型，并研究其多药耐药机制。

Objective To establish an animal model of refractory epilepsy by peritoneal injection of phenytoin sodium ( PHT ) and phenobarbital sodium ( PB ), and investigate into their multidrug resistance mechanism in kindling rats .

目的研究服用苯妥英钠（DPH），癫痫（EP）患者唾液与血清中DPH浓度关系，探讨测定唾液中DPH浓度替代血药浓度的可行性。

The relation ship between the salivary and the blood Diphenylhydantoin ( DPH ) Levels in the epileptic ( EP ) patients with oral dosing DPH were studied .

目的通过了解耐/非耐苯妥英钠（PHT）癫痫鼠与人类同源线粒体基因的差异表达来探索难治性癫痫的分子病理机制。

Objective To explore the molecular mechanism of intractable epilepsy through the differential expression of mitochondrial genes in brains between the phenytoin resistant and non resistant epileptic rats .

目的探讨苯妥英钠（Diphenylhydantoin，DPH）在急性缺氧条件下的脑保护作用。

Objective The aim of this study was to investigate the role of diphenylhydantoin ( DPH ) in protection of brain against acute hypoxia .

报告25例单用苯妥英钠（PHT）和12例PHT与卡马西平（CBZ）联用引起中毒的癫痫患者的血药浓度。

He serum phenytoin concentration was reported in epileptic patients who were poisonedwithphenytoin ( PHT ) monotherapy in 25 cases and with phenytoin combined with carbamazepine ( CBZ ) in l2 cases .

结果戊四氮（PTZ）可诱发癫痫大发作，如若在注入PTZ前30min先注入地塞米松或苯妥英钠（DPH）能减轻或抑制大鼠癫痫发作症状。

Results Major epilepsy was induced by pentylenetetrazole ( PTZ ) . Dexamethasone or diphenylhydantoin ( DPH ) administered in rat 30 ? min before administration of PTZ could suppress or inhibit epileptiform .

结果（1）服用苯妥英钠（PHT）的女性病人血清PRL明显升高，且血清PRL与PHT浓度呈正相关。

Results ( 1 ) The serum PRL levels in women received phenytoin ( PHT ) were significantly higher than the controls , and there was positive relationship between serum PRL and PHT levels ( P < 0.05 );

苯妥英锌腹腔注射的ED（50）和LD（50）分别为9.74和138.1mg/kg，治疗指数与苯妥英钠接近，刺激性比苯妥英钠小。

ED_ ( 50 ) and LD_ ( 50 ) of phenytoin zinc ip were 9.74 and 138.1 mg / kg respectively . The therapeutic index of phenytoin zinc was closed to that of phenytoin sodium , but its irritability was less than that of later .

末次灌胃1h后，各组ig苯妥英钠50mg·kg-1，于给药后1,2,3,4,5,7,9,12,15,20和25h后剪尾取血，高效液相色谱法检测血浆中苯妥英钠的浓度，并计算药动学参数。

Each group was given phenytoin 50mg · kg-1 after 1 h at the last time given TCD and Cut tail draws blood after 1,2,3,4,5,7,9,12,15,20 and 25h after the treatment . To detect plasma dilantin sodium concentrations used High performance liquid chromatographic and calculated pharmacokinetic parameters .

长期服苯妥英钠癫痫患者的骨代谢研究

The bone metabolism in epileptic patients on long-term treatment with phenytoin

苯妥英钠与卡马西平在健康志愿者体内药物动力学相互作用

The pharmacokinetic interactions of phenytoin and carbamazepine in healthy Chinese volunteers