苯中毒

结论有效组属于苯中毒AAA，无效组可能为原发性AAA。

Conclusion Effective group belongs to AAA due to benzolism , ineffective group may be primary AAA .

补肾养血方治疗慢性苯中毒34例疗效观察

Treatment of 34 Cases of Chronic Benzolism with Bushen Yangxue Tang

苯中毒病人外周血淋巴细胞DNA损伤的检测

Detection of damaged peripheral lymphocyte DNA in patients with benzene intoxication

苯中毒恒河猴骨髓细胞DNA代谢的研究

Study on the metabolism of DNA in bone marrow of benzene-intoxicated monkeys

DNA损伤修复能力与慢性苯中毒关系研究

Study on repair capacity of DNA damage associated with chronic benzene poisoning

慢性苯中毒小鼠DNA氧化损伤的单细胞凝胶电泳检测

Study on DNA Oxidative Damage in Benzene Exposed Mice by Single Cell Gel Electrophoresis

SD大鼠苯中毒模型的建立与检测

Establishment of a model of benzene toxicosis in SD rats

用cDNA微阵列分析苯中毒肿瘤相关基因表达谱

Analysis on tumor related gene expression profiles in benzene poisoning using cDNA microarray

目的筛选与苯中毒有关的DNA复制及损伤修复基因。

Objective To screen DNA replication , and damage repair genes associated with benzene poisoning by using gene expression profile analysis .

谷胱甘肽转移酶T1基因型与苯中毒遗传易感性

Glutathione S - transferase T1 genotype and susceptibility to benzene poisoning

苯中毒小白鼠血液中SOD过氧化物酶GSH过氧化物酶变化的实验研究

Experimental study on changes of SOD and glutathione peroxidase in blood of mice exposed to benzene

结论：该方法建立的SD大鼠苯中毒模型可用于苯中毒疾病研究。

Conclusion : This model is successful and may be used to study benzene toxicity for human body .

本文对苯中毒小白鼠血液中SOD、过氧化物酶、GSH过氧化物酶的变化进行了实验研究。

The changes of SOD and glutathione peroxidase in blood of mice exposed to benzene were studied .

为观察急性苯中毒对小鼠骨髓细胞超微结构的影响，用BALB／c小白鼠做了急性毒性实验。

The acute toxic effects of benzene to the ultrastructural changes in bone marrow cells of BALB / c mice were studied .

慢性苯中毒患者T淋巴细胞rDNA转录活性的研究

Study of T lymphocyte rDNA transcription activity in chronic benzene poisoning patients

用cDNA微阵列芯片检测苯中毒细胞色素P450基因表达差异

Analysis on differential expression profile of cytochrome P450 genes in benzene poisoning cells using cDNA microarray

GPA基因突变与慢性苯中毒的关系

Association of glycophorin A gene mutation in peripheral erythrocytes and chronic benzene poisoning

苯中毒再生障碍性贫血患者骨髓细胞免疫功能和Fas、CD34抗原变化

Alteration of Fas and CD34 antigen expression and cellular immune function in patients with aplastic anemia caused by benzene poisoning

探讨谷胱甘肽硫转移酶（GST）基因多态与慢性苯中毒患者血清中必需元素的关系。

To study the relationship between essential elements and GST genetic polymorphisms in patients with chronic benzene poisoning .

结果联合治疗苯中毒中，再障2例均治愈，1例骨髓增生异常综合征（MDS）明显进步，1例急性造血停滞治愈。

Results 2 cases of aplastic anemia were cured and 1 case MDS was improved and 1 cured of stasis to produce blood .

部分苯中毒导致的再障患者即使无IST的应用，造血干细胞的损伤也能逐渐恢复。

The destruction of hematopoietic stem cells induced by benzene can recover gradually in some patients even without IST .

毛大丁草多糖C（Gcp）对苯中毒小鼠的升白作用及其机制研究

Study on the Treatment Effects and the Mechanisms of Gerbera Piloselloides ( Linn . ) Cass . Polysaccharide C ( Gcp ) on Increasing Leukocyte Counts in Benzene Intoxicated Mice

目的观察慢性苯中毒患者外周血T淋巴细胞rDNA转录活性的变化，探讨其对慢性苯中毒人群免疫监测的意义。

Objective To observe the changes in peripheral blood T lymphocyte rDNA transcription activity and to study the significance of immune monitoring for patients with chronic benzene poisoning .

方法应用姐妹染色单体交换（SCE）技术，对22例苯中毒病人和30例正常人外周血淋巴细胞SCE频率进行检测分析。

Methods The sister chromatid exchange ( SCE ) frequencies in peripheral blood lymphocytes of22 patients with benzene intoxication and30 normal people were detected by SCE technique .

结果表明，轻度苯中毒时，其骨髓毒性可能主要由于骨髓分化细胞DNA的合成受到干扰而引起，骨髓造血微环境可能也受到波及。

The results revealed that in mild benzene poisoning the myelotoxicity seemed primarily due to the depression of the repopulation ability of differentiated bone marrow cells by the interference in DNA synthesis , and probably the hematopoietic inductive microenvironment ( HIM ) was also involved .

苯中毒病人SCE率为（6.31±1.26）次/细胞，对照组（5.59±0.18）次/细胞；

SCE rate in benzene poisoning cases was ( 6.31 ( 1.26 )) times / cell , and in the control group ( 5.590.18 ) times / cell .

随着苯中毒的程度加重，GSH-Px活性下降，且低于对照组，尤其表现在苯重度中毒组病人全血中的GSH-Px。

With the aggravation of intoxication , GSH Px activity decreased gradually , and significantly lower than that of the control , especially as far as severe intoxication workers are concerned .

目的探讨细胞免疫功能、Fas和CD34抗原与苯中毒再生障碍性贫血发生、发展及转归的关系。

Objective To explore the relationship of the expression of Fas and CD34 antigen and cellular immune function with occurrence , progress , prognosis , outcome and pathological mechanism of benzene poisoning aplastic anemia ( BPAA ) .

结果提示：在苯中毒早期WBC在正常范围时，GSH过氧化酶、SOD和过氧化物酶已发生变化，为我们进一步研究苯中毒早期诊断指标提供了重要依据。

The results showed that the changes of SOD and glutathione peroxidase were prior to that of the counts of WBC and it gave us an important clue for further study on early diagnostic indexes of benzene poisoning .

方法用HLA配型全相合的女性供者异基因外周血造血干细胞移植（alloPBSCT）治疗1例苯中毒致SAA男性患者。

Methods HLA-compatible sibling ( pregnancy ) allogeneic peripheral blood stem cell transplantation ( Allo-PBSCT ) was successfully performed for a patient with severe aplastic anemia caused by benzene poisoning .