化学致癌

长期多次涂抹PMA，可以诱发小鼠皮肤乳头状瘤的发生进而实现化学致癌的发生发展。

Long-term repeated PMA smearing , could induce the occurrence of skin papilloma in mice so as to realize the occurrence and development of chemical carcinogenesis .

因此搞清大鼠GST-P基因转录调控机制对于了解癌变过程中GST-P基因表达的增强方式，了解化学致癌的机理，为进一步寻找对癌症的综合治疗和预防方法提供理论依据。

Therefore clarifying the transcriptional regulatory mechanism of GST-P gene appears to be very important to elucidate the induced expression of GST-P gene during carcinogenic processes and to determine the mechanisms of chemical carcinogenesis , which will provide the theory for the therapy and precaution to carcinoma .

化学致癌物能直接在DNA上造成修饰和损伤：如果没有被正确修复，这些损伤将导致突变的形成。

Chemical carcinogens can cause modifications or damages on DNA directly .

化学致癌物诱导悬浮大鼠肝细胞DNA非程序合成的研究

A study on unscheduled DNA synthesis in freshly suspended rat liver cells induced by chemical carcinogens

化学致癌物可损伤细胞DNA，使基因发生突变，从而引起肿瘤。

Chemical carcinogens can damage cell DNA to result in gene mutation , and then eventually lead to tumor development .

大多数化学致癌物均可影响DNA、RNA和蛋白质合成的过程。

It was known that most chemical carcinogens could interfere with the synthesis of DNA , RNA and protein .

电离辐射及化学致癌剂（BP）诱发鼠胚培养细胞姊妹染色单体互换及染色体畸变的研究

Sister chromatid exchanges ( sce ) and chromosomal aberrations of cultured cells of mouse embryo induced by ionizing radiation and chemical carcinogen

Y家族DNA聚合酶对化学致癌物MNNG应答的转录调控研究

Transcriptional Regulation of Y-family DNA Polymerase in Response to the Carcinogen N-methyl-N ' - nitro-N-nitrosoguanidine

目的：探讨草苁蓉（BR）对大鼠肝脏化学致癌作用的抑制效应。

Objective : To investigate the inhibitory effect of Boschniakia rossica ( BR ) on hepatocarcinogenesis in rats .

EB病毒及化学致癌物DNP对人胚鼻咽粘膜裸鼠移植的诱癌研究

Carcinogenesis of Epstein-Barr virus and chemical carcinogen DNP on transplants of human fetal nasopharyngeal mucosa in nude mice

化学致癌物DNP致人胚鼻咽上皮细胞转化相关基因的鉴定

Identification of the Gene Involved in DNP-induced Neoplastic Transformation of Human Embryonic Nasopharyngeal Epithelial Cells

目前，普遍认为EB病毒感染、遗传因素和化学致癌物是导致鼻咽癌发生的三大主要原因。

Nowadays , Epstein-Barr virus ( EBV ), certain chemical carcinogens and genetic factors are thought to be closely associated with the pathogenesis of NPC .

目的：探讨蛙皮素在化学致癌剂N鄄甲基鄄N'鄄硝基鄄N鄄亚硝基胍（MNNG）诱发人胃黏膜上皮永生细胞系GES鄄1癌变过程中的作用。

Aims : To investigate the effects of bombesin on the malignant transformation of immortalized human gastric epithelial cell line GES-1 induced by chemical carcinogen N-methyl-N ′ - nitro-N-nitrosoguanidine ( MNNG ) .

结论：蛙皮素可与化学致癌剂协同促进正常上皮细胞癌变，其机制可能与cyClinD1的过表达有关。

Conclusions : Bombesin seems to exert a synergistic effect with chemical carcinogen in promoting malignant transformation of normal epithelial cells , which may be related to the increased cyclin D1 expression .

本文研究了碱式醋酸铅（BLA）对化学致癌物诱发小鼠肺肿瘤的影响。

The effects of basic lead acetate ( BLA ) on the induction of lung tumors were studied in mice treated with chemical carcinogens .

鼻咽癌患者外周淋巴细胞经紫外线或化学致癌剂N-甲基-N'-硝基-N-亚硝基胍（MNNG）处理后，其非程序DNA合成（UDS）值比健康人的为低；

Using UV or MNNG as inducing agents , the UDS values of peripheral lymphocytes from patients with nasopharyngeal carcinoma ( NPC ) were found to be lower than that from normal healthy subjects .

而发病与化学致癌物有关的肺癌中有5／10例检测到有p53基因突变，其中1例发生在外显子8，4例发生在外显子5。这5例均有p53的过表达。

No NPC or cervical carcinoma had p53 mutations in exons 5 8 of the gene , whereas mutations were found in 5 lung cancers , one in exon 8 and four in exon 5 . All five cases showed p53 overexpression .

目的：探讨珍珠梅乙酸乙酯提取物在大鼠肝脏化学致癌初期对谷胱甘肽S-转移酶（GST-P）表达的影响。

Objective : To study the effect ethyl ester extract of Sorbaria Sorbifolia on glutathione S-transferase at early stage of rat 's chemical hepatocarcinogenesis .

方法：1.取体重150～200g雄性近交系F334大鼠150只，随机分为实验组和对照组，利用化学致癌剂二乙基亚硝胺（DEN）建立起近交系F334大鼠肝癌模型。

150 male inbred rats ( 75-100Kg ) are divided into experimental group and control group randomly , the rat of liver cancer model is established by low dose DEN . 2 .

结论：珍珠梅乙酸乙酯提取物在大鼠肝脏化学致癌初期对GST-P的表达率有抑制作用

Conclusion : The ethyl ester extract of Sorbaria Sorbifolia can reduce the rate of expression of glutathione S-transferase at early stage of rat 's chemical hepatocarcinogenesis

为了探讨DNP致癌的分子机理，鉴定出化学致癌物二亚硝基哌嗪（DNP）致人胚鼻咽上皮细胞转化相关的基因及其活化方式。

To identify the genes and explore the molecular mechanism involved in neoplastic transformation of human embryonic nasopharyngeal epithelial ( HENE ) cells induced by N , N ' - Dinitrosopip erazine ( DNP ) .

采用化学致癌物与非致癌物的健康风险评价模型，结合有关机构和作者推荐的最大可接受风险水平，对上海市多介质环境下的致癌类与非致癌类PTS进行定量化的风险评估。

Using the health risk assessment model of chemical carcinogens and non-carcinogens and combing with the maximum acceptable risk level recommended by relative agencies and authors , the paper develops the risk assessment of carcinogenic and non-carcinogenic PTS in different ambient medium of Shanghai .

结论：化学致癌剂诱发实验性早期肝癌过程中，IL6可能是激活HGF的细胞因子，HGF以自分泌机制发挥促肝细胞增殖的效用。

Conclusions During rats are induced into early hepatocellular carcinomas by chemical carcinogen , the gene of HGF may be actived by a cytokine , IL 6 . An autocrine mechanism was suggested in HGF for the proliferation of hepatocytes .

结果说明尽管脾脏本底的生物转合酶活性很低，但仍可被化学致癌物诱导，并且提示了在淋巴细胞中诱导细胞色素P448的可能性。

The results indicate that rat lymphoid tissue cells can respond to chemical insults such as MQCA by a cytochrome P448 induction response .

尤其大鼠GST-P在化学致癌早期的癌前病变细胞（启动细胞）中表达大大升高，因此被作为癌变最稳定、最准确的标志酶之一。

Especially GST-P expressed at a high level in preneoplastic cells ( initiated cells ) from very early stage of chemically induced carcinogenesis in rat . On account of this , GST-P is regarded as one of the most stable and reliable preneoplastic and neoplastic marker enzymes .

大白鼠肝脏化学致癌过程中诱导产生的尿苷二磷酸葡萄糖醛酸基转移酶的纯化及其性质的研究

Purification and Characterization of UDP Glucuronyltrans ferases Induced during Rat Hepatocarcinogenesis

化学致癌物体外转化大鼠气管上皮细胞的研究

In Vitro Transformation Induced by Carcinogens in Rat Tracheal Epithelial Cells

化学致癌物对体外培养人胚鼻咽上皮的影响

The effect of chemical carcinogen on culture of human embryonic nasopharyngeal epithelium

限量饮食对化学致癌物-DNA加合物生成的影响

The effect of dietary restriction on the formation of carcinogen DNA adducts

化学致癌剂和化学致癌机理的研究状况

Situation for Researches on Chemical Carcinogens and on Mechanism of Chemical Carcinogenesis