刺突

SARS冠状病毒刺突蛋白编码基因及氨基酸序列的同源性分析

Homologous analysis of SARS-coronavirus spike protein encoding gene and amino acid sequence

SARS冠状病毒刺突蛋白的研究进展

Research advances in spike glycoprotein of SARS associated coronavirus

重组SARS-CoV刺突蛋白基因片段的原核表达及纯化

Over-expression and purification of recombinant spike protein fragment of SARS coronavirus

SARS-CoV刺突蛋白受体结合区的表达及高潜在中和性人源抗体的制备

Expression of Receptor-binding Domain of SARS-CoV Spike Protein and Isolation of Highly Potent Neutralizing Antibody

严重急性呼吸综合征患者核壳蛋白和刺突蛋白S1区的特异性抗体研究

Specific antibodies against the nucleocapsid protein and S 1 domain of spike glycoprotein in patients with severe acute respiratory syndrome

目的：冠状病毒（SARS-CoV）的刺突蛋白（Spikeglycoprotein，S蛋白）是病毒的主要结构蛋白之一，也是重要的病毒抗原，重组S蛋白的表达可用于检测病毒感染后血清抗体。

Objective : To obtain the spike glycoprotein ( S protein ) of SARS coronavirus ( SARS-Cov ) for detection of the corresponding antibody and preparation of diagnostic kits .

结论预测的SARS冠状病毒S2刺突蛋白B细胞表位肽能够诱导家兔产生针对S2蛋白的抗体，为研制抗SARS病毒基因工程疫苗奠定了基础。

CONCLUSION : The predicted B cell epitope peptide of SARS coronavirus S2 spike protein can induce the antigenicity of S2 protein , which provides some fundamental data for developing engineering vaccine against SARS coronavirus infection .

目的探讨板蓝根抗内毒素活性部位F022对脂多糖（LPS）刺激小鼠组织膜结构伸展刺突蛋白mRNA（moesinmRNA）表达的影响。

Objective To probe into the effect of the anti-endotoxic part in Radix Isatidis on the expression of moesin mRNA in tissues of mice induced by lipopolysaccharide ( LPS ) .

目的探讨SARS冠状病毒的刺突（spike，S）蛋白的免疫学特性，以及S蛋白作为SARS-CoV病毒疫苗组分的可行性。

Objective To study the immunological characteristics of the spike ( S ) protein of SARS coronavirus ( SARS-CoV ) and analyze the feasibility of using this protein as the component for SARS vaccine development .

方法：用间接ELISA法检测人和哺乳动物血清SARS冠状病毒（SARS-CoV）核衣壳蛋白（H）和刺突糖蛋白S1片段（S1）IgG滴度，并测定相应抗体的总亲和力。

Methods : Serum samples of healthy contact persons and mammals were detected with indirect ELISA for the titers and relative affinities of SARS-CoV nucleocapsid protein ( H ) and spike glycoprotein fragment 1 ( S1 ) IgG .

目的：SARS冠状病毒表面的刺突蛋白（Spike，S蛋白）可与宿主细胞上的病毒受体血管紧张素转化酶2（Angiotensin-ConvertingEnzyme2，ACE2）结合，介导病毒进入细胞。

AIMS : The spike protein ( S protein ) on the surface of SARS coronavirus can induce virus entering into the host cell by means of binding to the Angiotensin-converting enzyme 2 ( ACE2 ), the virus receptor on the cell .

禽流感病毒利用一种被称为血凝素蛋白的“棒棒糖形状”的刺突去入侵鼻和肺细胞。

The flu virus uses a " lollipop-shaped " spike known as hemagglutinin to invade nose and lung cells .

这种刺突的尖端不断变异，这意味着流感疫苗必须每年重新修改。

The tip of the spike mutates continually , which means that flu vaccines must be redefined every year .

一旦附着于其上，抗体就阻止了刺突把病毒的基因注入人类细胞，让它无法复制。

Once attached , the antibodies prevent the spike from injecting the virus 's genes into human cells , rendering it unable to replicate .

Ⅰ.PPARγ与小分子以及相关受体蛋白的相互作用研究Ⅱ.SARS冠状病毒刺突蛋白免疫片段的热力学和动力学研究

ⅰ . Interaction between PPAR γ and Ligands or Relative Nuclear Receptor ⅱ . Thermodynamic and Kinetic Investigation of SARS_CoV Spike Glycoprotein Immunological Fragment

冠状病毒也不例外，是通过其包膜糖蛋白-刺突（S）蛋白与宿主细胞表面受体结合后引起膜融合的；S蛋白在病毒包膜表面形成了冠状病毒特征性的突起，大而明显。

The envelope glycoproteins , spike ( S ) glycoproteins , of coronaviruses are no exception and mediate binding to host cells followed by membrane fusion ;

这组科学家回避了这个问题，发现了一个接触非变异的刺突颈部的方法，并且选出了可以附著于其上的抗体。

The team have sidestepped this by finding a way to expose the non-mutating neck of the spike and selecting antibodies that can attach themselves to it .

身体乌黑或淡红色。八条触手上列满吸盘，还有一排排名为腕丝的柔软肉质刺突，类似章鱼。

Jet black to pale red in color , eight arms lined with suction cups and rows of soft fleshy spines known as cirri . , like an octopus .

对其他种类冠状病毒的研究结果显示，刺突蛋白（S蛋白）和膜蛋白（M蛋白）是病毒主要的结构蛋白。

Studies on other species of coronaviruses indicated that the spike protein ( S protein ) and membrane protein ( M protein ) are the main structural proteins of the virus .