内异症

目前国内外关于NF-кB在内异症发病机制中作用的研究甚少。

Currently , there are not systematic studies on the role of NF - к B in the pathogenesis of endometriosis .

内异症与非内异症子宫内膜均可分离培养成功（P0.05）。

The glandular epithelial cells from both endometriosis and non-endometriosis can be isolated and cultured successfully ( P0.05 ) .

结论内异症模型鼠脾脏NK细胞活性下降，内膜中NK细胞数减少。

Conclusion The NK cell number and activity of model rat decreased .

内异症Ⅰ-Ⅱ期患者IL-10水平与对照组比较差异无显著性（P＞0.05）。

There was no different amount of IL-10 between patients with mild endometriosis and controls ( P > 0.05 ) .

结论内异症患者腹腔液中VEGF升高是腹腔微环境改变导致内异症的原因。

Conclusion The VEGF increasing of patients with EM may cause the changing of the celiac microenvironment which leads to EM.

IGF-I促进异位子宫内膜生长，与内异症形成有关。

IGF-I can motivate ectopic endometria growth and is concerned with endometriosis .

米非司酮与GnRHA预防内异症术后复发的疗效观察

Clinical Observation on the Effects of Mifepristone and GnRH-a for Postoperative Pelvic Endometriosis

结果表明内异症组与盆腔炎组外周血免疫球蛋白IgA、IgM、IgG均升高，与对照组相比，有显著性差异（P＜0.01）；

Results : As compared with Group ⅲ, the contents of Ig rise significantly in Group I and Group ⅱ ( P < 0.01 );

目的：探讨核转录因子（NF-κB）和血管内皮生长因子（VEGF）的表达与子宫内膜异位症（内异症）预后的关系。

Objective : To investigate the prognostic value of nuclear factor-kappa B ( NF - κ B ) and vascular endothelial growth factor ( VEGF ) in endometriosis patients .

IL-6在内异症血液及腹腔液中水平与对照组中的水平分别比较均显著升高（P＜0.05）；

Significantly elevated levels of interleukin-6 ( cytokines of T help cell 2 ) were found in the serum and intraabdominal of patients with endometriosis ( P < 0.05 ) .

survivin基因在正常子宫内膜、内异症中的表达及GnRH-a、COX-2抑制剂对其表达的影响

Survivin Expression in Endometriosis and Normal Human Endometrium and Effects of GnRH-a and COX-2 Inhibitor on It

方法：分别采用免疫组化和实时定量逆转录-聚合酶链反应（Real-TimeRT-PCR）检测内异症患者在位内膜及正常对照中galectin-3蛋白及mRNA的表达，比较其表达差异。

Methods : Immunohistochemistry was used to detect the location and expression of galectin-3 protein . The mRNA expression of galectin-3 was detected by real-time quantitative RT-PCR .

结论：（1）内异症患者的子宫在位内膜和异位内膜的NK细胞的数量无明显变化；

Conclusion : ( 1 ) There is no significant difference in the number of NK cells between ectopic and eutopic endometrium in patients with EM.

观察内异症在位内膜细胞与正常内膜细胞中paxillinmRNA及蛋白达水平的差异。

To observe protein and mRNA level of Paxillin in endometriosis entopic endometrial cells and normal endometrial cells . 4 .

内异症子宫内膜细胞色素芳香化酶P-450的表达与AFS分期无相关性。

No correlation was observed between the expression of aromatase cytochrome P450 and AFS stage of endometriosis .

Northern杂交比较不同类型异位病灶之间以及内异症患者的在位内膜与非内异症的对照子宫内膜之间IL鄄8mRNA表达强度的差异。

The differences of IL-8 mRNA expression in eutopic endometrium of patients between with and without endometriosis , and the differences among different endometriotic lesions were further studied by Northern Blotting .

结论：小柴胡汤联合丹那唑对大鼠内异症具有明显治疗作用；小柴胡汤治疗机制有可能是通过下调异位内膜COX-2的表达，从而减少前列腺素的产生而实现的。

Conclusion : The mechanism of Xiao Chaihu Tang on the treatment endometriosis may be to decrease the COX-2 expression and reduce the prostaglandin synthesization .

目的：研究NMDA受体及nNOS的表达与子宫内膜异位症疼痛的相关性，分析NMDA受体及nNOS在内异症疼痛发生中的意义，探讨内异症疼痛的可能机制。

To study the correlation between the expression of NMDA receptor , nNOS and pain in endometriosis and their significance .

结果：NF-κB在内异症患者的异位和在位内膜中的表达率分别为73.49%及59.04%，VEGF表达率分别为69.88%及和55.42%。

Results : The positive rates of NF - κ B and VEGF expressions were 73.49 % and 69.88 % respectively in ectopic endometrium , and 59.04 % and 55.42 % respectively in eutopic endometrium .

探讨血管内皮生长因子VEGF和趋化因子RANTES在内异症患者异位和在位子宫内膜中的表达变化及意义。

To study the expression of VEGF and RANTES in ectopic and eutopic endometrium in patients with endometriosis and significance of the expression . 3 .

内异症患者异位和在位内膜中VEGF和RANTES的表达明显增强，与内异症的发生、发展密切相关。

Significantly increased expression of VEGF and RANTES in ectopic and eutopic endometrium in patients with endometriosis may be closely related to pathogenesis of endometriosis .

目的探讨芳香酶P450和雌激素受体（ER）在子宫内膜异位症（内异症）患者在位内膜与不同部位异位内膜中的表达及其相关性。

Objective To detect the expression of aromatase P450 and estrogen receptor ( ER ) in eutopic and ectopic endometrium in endometriosis and their correlation with endometriosis .

结论类似肿瘤的转移和侵袭机制，c-Met、MMP-2在内异症的发病中发挥了重要作用。

Conclusion Analogous to tumour metastasis and invasive mechanism , c-Met and MMP-2 may play an important role in the pathogenesis of endometriosis .

研究方法1、应用Real-timePcR、westernblot和免疫组化比较内异症患者与非内异症妇女在位内膜中stathmin和Annexin-1的表达。

The expression of stathmin and Annexin-1 in eutopic endometrium of women with and without endometriosis was detected by Real-Time PCR , immunohistochemistry and Western blot . 2 .

在位内膜VEGF和RANTES的高表达有望成为早期诊断内异症和治疗的新途径。

The high expressions of VEGF and RANTES in eutopic endometrium is expected to become a new target of early diagnosis and therapy of endometriosis . 3 .

测定内异症患者血清与腹水中，Bcl-2与PGE-2的浓度，从蛋白水平探讨腹腔局部环境中Bcl-2与PGE-2的表达与内异症发病的关系。

To detect the concentrations of PGE-2 and Bcl-2 in sera and peritoneal fluid of women with and without endometriosis .

目的：探讨子宫内膜芳香化酶细胞色素P450（简称芳香化酶P450），CA125联合检测对子宫内膜异位症（简称内异症）的诊断价值。

Objective To evaluate the diagnostic value of examining endometrial biopsy specimens for aromatase cytochrome P450 and CA_ ( 125 ) for endometriosis .

免疫组化和TUNEL法观察分析内异症患者在位内膜与正常内膜增殖与凋亡的特点，并分析与Fas／FasL促凋亡系统的关系。

Observe and analysis the proliferation and apoptosis of endometrium using IHC and TUNEL and the relationship with Fas / FasL , the apoptosis promoting system . 5 .

抑制MMP在盆腔内的含量，改善生殖内环境可提高内异症性不孕症的治愈率。

To reduce the level of MMP-2 in pelvic cavity and improve inner environment of reproduction may have action for increasing cure rate of infertility of endometriosis .

在中重度内异症同一期别中，RANTES在异位内膜中的表达均明显高于在位内膜，差异有统计学意义（P0.05）。

The expression of RANTES in ectopic endometrium was obviously higher than that in eutopic endometrium of the same clinical stage in patients with moderate-severe endometriosis ( P0.05 ) . 3 .