保护基

我们找到了供体3'-端不带磷或其他保护基时，其自聚或自身环化的产生都不明显的条件，从而使供受体用量比大大降低。

We tried to find the proper conditions under which self-ligation among donor molecules were not obvious in the absence of a protecting group at the 3 ' - terminus of the donor .

方法通过三苯甲醚保护伯醇、氧化仲醇、脱去保护基的方法，合成3酮基12羟基13,14烯穿心莲内酯。

Methods 3-one-12-hydroxy-13,14-ene-andrographolide was synthesized in a three-step route , including protecting primary alcohol of andrographolide by trityl ether , oxidating secondary alcohol and removing protecting group , etc.

RNA化学合成中的保护基

Protection Groups in RNA Synthesis

其次从某点开始用有目的的终止技术芯片技术、保护基技术以及杂交实验得到起点和终点相同的DNA链；

Then DNA chains having same jumping-off point and end point are obtained using purposive ending technology , which contains chip technology , protecting acid radical technology , hybridization experiment ;

利用谷氨酸的γ羧基与4甲基二苯甲基胺（MBHA）树脂的氨基偶联固相，合成经HF切割去保护基后形成C端是谷氨酰胺的人胰岛素原C肽。

Human proinsulin C-peptide with C-terminal glutamine amide could be prepared through solid phase method by combining the γ - carboxyl group of glutamic acid with the amino group of MBHA resin . The protecting groups were cleaved by HF .

设计合成了含组氨酸残基碱基为胸腺嘧啶的手性肽核酸单体，咪唑氨基的最终保护基为2,4-二硝基苯基（Dnp）。

A chiral peptide nucleic acid ( PNA ) monomer containing histidine residue and thymine has been designed and synthesized employing 2,4-dinitrofluorobenzene to protect the NH group of imidazole .

通过催化氢化去除苄基保护基得到聚（5-羟甲基-1,4-二氧六环-2-酮）（PHDON），并用FTIR、1HNMR、13cNMR和GPC等方法对聚合物进行了表征。

The protecting benzyl group was removed subsequently by catalytic hydrogenation to give poly ( 5-hydroxymethyl-1,4-dioxan-2-one )( PHDON ) with pendant hydroxyl groups . The polymers obtained were characterized by FTIR , 1H NMR , 13C NMR and GPC .

我们发现这些带有保护基的寡聚核苷酸在DEAE-葡聚糖A-25（Cl~-型）柱上，用含有3M尿素和40%乙醇的氯化锂溶液洗脱，可以克服这一困难。

This difficulty can be overcome by separation on a DEAE-sephadex A-25 ( Gl-form ) column instead of a DEAE-cellulose column , followed by elution with lithium chloride solution containing 3M urea and 40 % ethanol .

从全合成战略与路线、关键反应、保护基应用和立体化学方面对Holton的线性全合成紫杉醇路线进行剖析归纳。

The review described the total synthesis of taxol developed by Holton , including the synthetic strategy and routes , key reactions , application of protective groups and stereochemistry .

对甲苯磺酰基酰胺和2-苯基-N，N'-二甲基苯并咪唑啉（PDMBI）之间的光诱导电子转移反应，为酰胺的保护基&对甲苯磺酰基的脱除反应，提供了一条有效途径。

The photoinduced electron transfer reaction between N-tosyl amides and2-phenyl-N , N ' - dimethyl benzimidazoline ( PDMBI ) provides an efficient approach for the deprotection of N-tosyl amides .

分析了不同的离去基团和不同的保护基策略对糖肽合成的影响。

The factors which affect the results of glycopeptide synthesis were analyzed .

以烯丙基作为核苷中糖羟基保护基的研究

Studies on the Allyl Protection of Hydroxyl Group in Nucleosides

讨论了盐酸的用量对保护基脱除效率的影响。

The effect of the concentration of HCl was discussed .

头孢菌素羧基保护基的脱除方法研究进展

Research Progress of Deprotection for Carboxylic Ester of Cephalosporins

羰基的三甲基硅腈保护基脱除新方法

A novel method for deblocking the trimethylsilyl cyanide protective group in carbonyl compounds

二丁基氧化锡在糖苷类化合物脱乙酰保护基中的应用

Application of Dibutyltin Oxide to Deacetylation of Glucosides

带保护基的胆囊收缩素活性多肽类似物的合成及其活性研究

Synthesis of Protected Active Peptide Analogues of Cholecystokinin and Study of Their Biological Activities

含半胱氨酸多肽的研究&Ⅲ.牛胰岛素A链带保护基的氨端九肽的合成

Cysteine peptides & iii. synthesis of a protected N-terminal nonapeptide of the A-chain of bovine insulin

肽的研究&Ⅱ.带保护基的胰岛素A链羧端九肽的合成

Studies on peptides ⅱ . synthesis of a protected C-terminal nonapeptide of the A-chain of insulin

最后一步脱保护基的反应为平衡反应，该步反应收率受平衡条件的限制，经过优化后收率能达到78.1%。总收率达到54%，接近文献水平。

The finally reaction is an equilibrium reaction . The yield of this step is 78.1 % .

肽的研究&Ⅴ.新的带保护基牛胰岛素A链氨端五肽和九肽的合成

Studies on peptides & ⅴ . the synthesis of new protected N-terminal pentapeptide and nonapeptide of the A-chain of bovine insulin

2-氨基-2-脱氧-β-D-吡喃糖苷合成中氨基保护基的研究进展

Advances in amino - protecting groups used in synthesises of 2 - amino - 2 - deoxy - β - D - glycopyranoside

在寡糖和复合糖的合成中作为糖的端位保护基也有过成功的应用。

It has been successfully used for protection of the anomeric centre against standard reaction conditions in the synthesis of oligosaccharides and glycoconjugates .

本文介绍了用聚酰胺薄层层析的方法，分离和检定带保护基的核苷、核苷酸和低聚核苷酸。

A method of polyamide thin layer chromatography applicable to the separation and identification of blocked nucleosides , nucleotides and oligonucleotides is herewith described .

方法采用对硝基苯胺为原料，经还原、加保护基、甲酰化、氯化、环合、脱保护基六步反应法可进行化学合成。

Methods Apraclonidine was synthesized from P-Nitraniline by reaction with reduction , adding protection group , formylation , chlorination , cyclization , off-protecting group .

方法以市售唾液酸为原料，经5步反应4步操作制得生色底物1，即乙酰化、氯化、缩合和脱保护基。

METHODS The substrate 1 was synthesized from sialic acid via 4 steps . They were acetylation , chlorination , condensation and deprotection respectively .

过程中引入二乙胺基作为保护基，经还原加氢后再将保护基团脱去得到终产物。

The process is that diethylamino as protecting groups are bring in , then after a reductive hydrogenation reaction the protecting groups are taken off to get the final product .

在最后一步脱保护基的研究中，我们分别采用了锌粉还原和钯碳氢化两种方法得到最终产品，并对其后处理的方法进行了改进。

In the last step , we developed two methods of deprotection employing zinc dust and catalytic hydrogenolysis respectively to give the final product , and improved the work-up as well .

以洛伐他汀为原料，三甲基氯硅烷为羟基保护基，用活泼的强亲核试剂叔丁基锂代替当前的吡咯烷锂合成了目标产物新伐他汀，总收率达78%。

It can be synthesized with the material of lovastatin , hydroxy protecting agent of trimethylchlorosilane , and t-butyl lithium instead of pyrrole lithium . The total yield is about 78 % .

在有机中间体合成过程中作为一种温和的脱保护基基团[]以及一种有效的碱性试剂[]。

In the synthesis of organic intermediate compounds , cesium carbonate could be used as a mild and efficient reagent for deprotection [ 1 ] and as a base reagent [ 2 ] .