临床前

放射性氯化铊（~（201）Tl）注射液的临床前药理研究

Preclinical pharmacological study of thallium chloride ~ ( 201 ) Tl injectior

一种相关的神经靶向给药系统载体NG2在临床前动物试验中被证实可以降低神经损害和糖尿病引起的神经性疼痛。

A related NTDDS vector , NG2 reduces pain-related behaviors in preclinical models of neuropathic pain from nerve injury and diabetes .

ICH对药物临床前心脏安全性评价的技术要求

Technical requirements from ICH for Preclinical Cardiac Safety Evaluation of Pharmaceuticals

PPS紧密结合其它临床前的基础科学课程。

PPS is closely integrated with other preclinical " basic science " courses .

在该完整回复函中，FDA并未要求补充新的临床前或临床研究资料。

In the complete response letter there are no requests for new pre-clinical or clinical trials .

联合血小板淀粉前蛋白比和rCBF单光子发射计算机断层扫描分析对阿尔茨海默病进行临床前诊断

Pre-clinical diagnosis of Alzheimer disease combining platelet amyloid precursor protein ratio and rCBF spect analysis

3分别开展了6例同种异体人胚胎感光前体细胞和4例神经层视网膜细胞移植治疗RP的临床前试验。

We performed 6 cases of allograft fetal RPP cells transplantation and 4 cases of fetal neuroretina cells transplantation in RP patients .

结论研制了高质量的冻干小鼠神经生长因子，为NGF的临床前和临床研究奠定了基础。

CONCLUSION High qualified lyophilized mouse nerve growth factor has been produced , which has laid a foundation for further NGF application research .

重组腺病毒介导人野生型p53、GM-CSF和B7-1基因对恶性肿瘤生物治疗的临床前研究

Pre-clinical Study on Bio-therapy of Malignant Tumor with Human Wild-Type p-53 , GM-CSF and B7-1 Genes Mediated by Recombinant Adenovirus Vector

本文首次建立了测定血浆中阿德福韦浓度的液相色谱-串联质谱（LC／MS／MS）法，并应用此方法对阿德福韦地匹福酯的临床前药代动力学进行了系统的研究。

A new LC / MS / MS method for determination of adefovir in animal plasma was developed and validated and successfully used in the preclinical metabolism and pharmacokinetics study of adefovir dipivoxil .

临床前及临床研究正在开发基于TLRs信号通路的肿瘤免疫治疗。

The strategy of cancer immunotherapy based on TLRs signaling is developing in preclinical and clinical studies .

目的研究13N-氨水（13N-NH3·H2O）的临床前药理，探讨13N-NH3·H2O的PET显像方法及其在心脏疾患诊断中的应用。

: Objective To study the preclinical pharmacology of 13N-ammonia , and to explore its methods for clinical PET imaging and its application in diagnosis of heart diseases .

目的对促肝细胞生长素注射液（InjectionofPHGF）进行临床前实验研究，为新剂型的研究提供依据。

Objective For further research on the new form of PHGF , three lots of PHGF Injection stored for six months at room temperature as stepped-up test were studied as pro-clinic research .

RNAi现广泛用于多个生物体的功能基因组学研究，以及在基因表达异常导致的多种疾病的临床前模型中进行干预治疗。

RNAi is currently used for both systematic functional genomics in several organisms and for specific therapeutic intervention in preclinical models of different diseases characterized by aberrant gene expression .

大量临床前及早期临床试验结果提示EGFR是肿瘤治疗的靶点。

The results of a large body of preclinical studies and the early clinical trials thus far conducted suggest that targeting the EGFR could represent a significant contribution to cancer therapy .

基于MMPs的种类、结构和作用方式，已经发现了多种抑制剂，均处于临床前或临床研究阶段。

A number of MMPs inhibitors at clinical or pre-clinical stages have been developed for cancer treatment based on category , structure and mechanism of MMPs . Now , the (?)

它是中国唯一一家临床前CRO实验室，其研究数据被美国食品药物管理局（FDA）和欧洲药品管理局（EMEA）接受为重要规章备案文件的一部分。

It is the only preclinical CRO laboratory in China whose data have been accepted by both the FDA and EMEA as part of successful regulatory filings .

RoyFreeman教授：基于临床前研究的数据和最近的临床资料，有许多生化途径在神经变性的功能障碍中发挥着关键作用。

Prof Roy Freeman : There are a number of biochemical pathways based on preclinical data and more recently clinical data which play a key role in dysfunction of nerve degeneration .

下一步可能的工作：一旦该药物的正式的临床前毒理学试验完成，最快在2009年，开始针对MPD患者进行临床试验。

The next likely step will be to open clinical trials for people with MPD as soon as2009 once formal preclinical toxicology studies are completed .

结论：应用多克隆抗体可以检测体内外CD基因的表达，为临床前和临床上深入开展CD基因的生物治疗研究提供重要的实验材料。

CD recombinant protein . Conclusion With the polyclonal antibody , CD expression can now be monitored throughout in vitro and in vivo gene transfer studies with the polyclonal antibody . The polyclonal antibody can be used in further biological gene therapy of CD gene .

临床前药理实验研究结果表明：TW－SR与TW一样具有显著的抗炎、镇痛和免疫抑制作用。TW－SR毒性明显小于TW。

Results of pre-clinical pharmacologic experimental study showed that the TW-SR has obvious anti-inflammatory , analgesia and immunosuppress ' ive action as the TW has , while its toxicity was less than the latter significantly .

HBI-8000的临床前有效性和药代动力学特性预示，其临床特性可能优于目前市售或开发中的其他HDAC抑制剂。

The preclinical efficacy and pharmacokinetic properties of HBI-8000 may translate into an improved clinical profile over other HDAC inhibitors currently being marketed or in development .

他说，在这临床前的试验阶断，对认识HN如何用于人还为时尚早，但他相信自然肽在保护细胞方面是非常有前景的。

He says that in this preclinical testing period , it is still too soon to know how HN would perform in humans , but he believes the naturally occurring peptide 's ability to preserve cells is promising .

Patria疫苗已在不同种类的动物身上进行临床前试验，证明了其有效性。

The " Patria " vaccine has already demonstrated its effectiveness in pre-clinical tests on different species of animals .

目的研究一种新型基因工程人肿瘤坏死因子－α（nrhTNF－α）的临床前药理、毒理和药代动力学特性。

Aim To study the preclinical pharmacology , toxicology and pharmacokinetics characteristics of a novel recombinant tumor necrosis factor - α( nrhTNF - α) .

综合临床前研究方法学的进展，文章主要对BMSC的细胞类型、细胞移植的时间窗、细胞移植途径、移植细胞后体内追踪技术以及治疗效果评价等方面的最新进展做了综述。

Synthesizing the advances in methodology of preclinical studies , this article mainly reviews the types of BMSC , time window for cell transplantation , approaches of cell transplantation , tracing technique in vivo after cell transplantation , and treatment effectiveness evaluation .

临床前研究，Ⅰ和（或）Ⅱ期临床试验都已证实，HDAC的小分子抑制剂能够有效地促进抑癌基因表达，抑制肿瘤生长并诱导细胞凋亡。

Small molecular inhibitors of HDAC inducing histone acetylation are highly effective in up-regulating tumor suppressor gene ex - pression , repressing tumor growth and inducing apoptosis in preclinical studies and in phase ⅰ and ⅱ clinical trials .

经过几十年的临床前和临床研究，最初被证实具有辐射防护作用的药物WR-2721已经进入临床应用阶段，并已试用于多种肿瘤的辅助治疗。

After several decades of preclinical and clinical research , WR-2721 ( Amifostine ), the first approved radioprotective drug , has been introduced into the clinic and applied in auxiliary therapy of many kinds of tumors .

本文通过建立测定生物样品中两种新型喹诺酮衍生物CS-940及KNT-009浓度的高效液相色谱-紫外检测法（HPLC-UV），对两种化合物在动物体内的临床前药代动力学进行了系统的研究。

New HPLC-UV methods for the determination of CS-940 and KNT-009 in biological specimen were developed and successfully used in the preclinical metabolism and pharmacokinetics study of these two new quinolones .

TN-101是以血管细胞内皮生长因子受体（VEGFR）和成纤维细胞生长因子受体（FGFR）为靶点的选择性酪氨酸激酶抑制剂，临床前实验表明它能有效地抑制肿瘤血管生成。

TN-101 is a selective tyrosine kinase inhibitor , with vascular endothelial cell growth factor receptor ( VEGFR ) and fibroblast growth factor receptor ( FGFR ) as target spots . Pre-clinical study shows TN-101 can effectively inhibit tumor angiogenesis .