肾小球基底膜

结论：该方能降低HBA1c及减轻或延缓肾小球基底膜增厚。

Conclusion : HDG could decrease HBA1c and abate or delay the pachynsis of glomerular basement membrane .

Alport综合征患者肾小球基底膜超微结构改变与层粘连蛋白的异常分布

Correlation between ultrastructural changes of glomerular basement membrane and abnormal distribution of laminins in patients with Alport 's syndrome

免疫荧光显示IgG沿肾小球基底膜散在性细颗粒状沉积。

Immunofluorescence demonstrated scattered granular deposits of IgG along the capillary walls .

小儿IgA肾病与肾小球基底膜变薄

The children IgA nephropathy with the GBM thinning

HBV-GN之MN与NHBV-GN比较有四点不同：1，肾小球基底膜增厚但钉突不明显；

Compared to MN , there were four features in HBV-GN : 1 , incrassation of glomerular basal spiky projection was not obvious ;

应用SC-声刺激器、听觉脑干诱发电位（ABR）检测及对耳蜗、近端肾小管上皮细胞的线粒体、肾小球基底膜等电镜观察，研究豚鼠电生理和组织学改变。

The physiopathology of renal and cochlea in guinea pigs were examined using auditory brainstem response ( ABR ), SC sound irritation and electron microscope .

被动型Heymann肾炎大鼠肾小球基底膜电荷屏障的变化

The Changes in Anionic Sites in Glomerular Basement Membrane in Passive Heymann Nephritic Rats

结果：PHN大鼠肾小球基底膜阴离子位点明显减少。

Result : Anionic sites in GBM of PHN rats were fewer than those of normal rats .

目的：糖胺聚糖（Glycosaminoglycans，GAGs）是肾小球基底膜的主要组成成分，在维持肾小球滤过屏障正常通透性中起重要作用。

Objective : Glycosaminoglycans ( GAGs ) are the major component of the glomerular basement membrane .

背景和研究目的糖尿病肾病（diabeticNephropathy，DN）是糖尿病的严重并发症之一，其基本病理改变公认为肾小球基底膜增厚、系膜基质增生，最终弥漫性或结节性肾小球硬化。

Background and objective Diabetic nephropathy is one of serious complication of diabetes . It basic pathobiology change is that glomerular basement membrane thickening , mesenterium matrix hyperplasy , diffuse and nodular glomerulosclerosis .

目的：检测被动型Heymann肾炎（PHN）肾小球基底膜电荷屏障的变化。方法：将含肾小管抗体的抗血清腹腔注射于大鼠体内建立被动型Heymann肾炎（PHN）模型。

Objective : To investigate the glomerular charge barrier change in passive heymann nephritic ( PHN ) rats .

目的了解肾功能正常的抗肾小球基底膜（GBM）病的临床和病理特点。

Objective To investigate the clinical and pathologic characteristics of anti-glomerular basement membrane ( GBM ) disease with normal renal function .

方法对我科近10年来经肾活检确诊的100例新月体性肾炎进行回顾性分析，对患者血清进行抗中性粒细胞胞浆抗体（ANCA）和抗肾小球基底膜（GBM）抗体的检测。

Methods 100 patients with renal biopsy proven crescentic glomerulonephritis were retrospectively studied , whose serum ANCA and anti-GBM antibody were measured by ELISA .

结论羟苯磺酸钙能抑制胶原IV过度积聚、减轻肾小球基底膜增厚，这可能与抑制糖尿病大鼠肾脏TIMP1表达、上调MMP9/TIMP1比值有关。

Conclusion Calcium dobesilate can improve microangiopathy of diabetes mellitus by inhibiting the over-accumulation of collagen IV . Calcium dobesilate may also contribute to diabetes by inhibiting expression of TIMP-1 , up-regulating the rate of MMP-9 / TIMP-1 .

12例伴血尿的非NS中4例肾小球基底膜弥漫性变薄（DTBM）。

In 12 cases of non-NS with hematuria , diffuse thin basement membrane ( DTBM ) was observed in 4 cases .

结果：（1）糖尿病肾小球基底膜（GBM）和系膜基质呈弥散和不均匀性增厚。

The results were as follows : 1 ) There was diffuse and uneven thickening of the glomerular basement membrane ( GBM ) and mesangium in NIDDM .

在电镜下应用医用图像处理系统测定肾小球基底膜厚度（GBMT）；

Glomerular basement membrane thickness ( GBMT ) was measured under electronic microscope with Medical Image System .

方法对21例有肾脏病家族史且诊断为TBMN患儿采用间接免疫荧光法检测皮肤基底膜（EBM）及肾小球基底膜（GBM）Ⅳ型胶原α链分布情况。

Methods Twenty-one patients , diagnosed as TBMN that all had the family history , detected the distribution α chains of ⅳ collagen in EBM and GBM by indirect immunofluorescence .

结果与未用药的硬化组比较，地塞米松（DEX）用药组肾小球基底膜增厚减轻；节段硬化、球囊增厚和间质炎性细胞的浸润明显减轻；

Results : Compared with the glomerulosclerosis group , in DEX group the thickening of glomerular basement membrane , segmental glomerulosclerosis , thickening of saccule and the infiltration of the interstitial inflammatory cells are all obviously alleviated .

目的探讨狼疮肾炎患者抗肾小球基底膜抗体（anti-GBM）与抗双链DNA抗体（anti-dsDNA）和抗核小体抗体（anti-NuA）的关系。

Objective To establish whether the anti-glomerular basement membrane antibodies ( anti-GBM ) correlate with anti-double stranded DNA antibody ( anti-dsDNA ) and anti-nucleosome antibodies ( anti-NuA ) in patients with lupus nephritis ( LN ) .

方法观察perindopril对肾小球基底膜、系膜和尿蛋白的影响及血浆和肾组织肾素活性、血管紧张素Ⅱ（ATⅡ），肾组织血管紧张素原mRNA表达的改变。

Methods Changes of indexes , which include glomerular basement membrane thickness , mesangial matrix volume density , urinary protein excretion rate , plasma and renal tissue renin activity 、 angiotensin ⅱ concentration and renal angiotensinogen mRNA expression level in rats with experimentally induced diabetes , were observed .

结果证实，应用GTW或CsA后大鼠移植肾肾长明显减少，肾重明显减轻，肾小球基底膜增厚，肾小管空泡变性、坏死及间质水肿明显减轻；

It was shown that the length and the weight of kidney were markedly decreased in the rats treated with GTW . The vacuolar degeneration and necrosis in renal tubules and interstitial edema could be dramatically improved in the rats treated with GTW .

采用间接免疫荧光法检测皮肤基底膜（EBM）Ⅳ型胶原α1、α5和肾小球基底膜（GBM）Ⅳ型胶原α1、α3和α5链表达。

The synthetic levels of α 1 and α 5 chains for epidermal basement membrane ( EBM ) type IV collagen and α 1 ,α 3 ,α 5 chain for glomerular basement membrane ( GBM ) type IV collagen were detected by indirect immunofluorescence .

结果：TBMN患儿肾小球基底膜中Ⅳ型胶原α1、α3～5链表达同正常，均为沿基底膜连续线状沉积。

RESULTS The α 1 (ⅳ) and α 3 5 (ⅳ) chains expressions were found linear positive along the GBM in TBMN patients , in a same pattern as in the normal controls .

方法：复制大鼠被动型Heymann肾炎（PHN）、抗胸腺细胞血清性肾炎（ATSN）、抗肾小球基底膜性肾炎（AGBMN）及慢性血清病肾炎（CSDN）4种动物模型。

METHODS : The four models of rats , namely , passive Heymann nephritis ( PHN ), anti-thymocyte serum nephritis ( ATSN ), anti-glomerular basement membrane nephritis ( AGBMN ) and chronic serum disease nephritis ( CSDN ) were reproduced .

羟苯磺酸钙对糖尿病模型大鼠肾小球基底膜的影响研究

Efficacy of Calcium Dobesilate on Glomerular Basement Membrane in Diabetic Rats

抗肾小球基底膜抗体的亲和力与肾脏病理表现密切相关

Avidity of anti-glomerular basement membrane autoantibodies was associated with renal pathological damage

普乐可复防治大鼠抗肾小球基底膜肾炎的实验研究

Effects of FK506 on anti - glomerular basement membrane nephritis in rats

肾小球基底膜病变与儿童无症状性血尿

Glomerular basement membrane lesions and asymptomatic hematuria in children

抗肾小球基底膜单克隆抗体放射免疫显像的研究进展

Development in radioimmunoimaging using antiglomerular basement membrane monoclonal antibody