晶状体蛋白

UV辐射可进一步降低硒性白内障α晶状体蛋白的分子伴侣活性。

UV irradiation further decreased chaperone activity of α crystallin from selenite cataractous lenses .

NorthernBlot显示热休克诱导心肌细胞αB晶状体蛋白mRNA的表达增加。

Northern blot showed that heat shock induced α B crystallin mRNA expression .

半乳糖诱导白内障大鼠异常晶状体蛋白X（36）与白内障形成的关系

Relationship between abnormal rat crystalline X_ ( 36 ) and galactose-induced cataractogenesis

α晶状体蛋白包括αA和αB晶状体蛋白，属于小分子热休克蛋白家族成员。

Alpha - crystallin includes α A and α B - crystallins , being a member of the small heat - shock protein family .

αB晶状体蛋白在许多器官、组织、细胞均有结构性表达，在抵御内、外环境应激发挥重要作用。

Alpha B is constitutively expressed in many organs , tissues , and cells . It holds some functions of resisting environment stress in vivo and in vitro .

方法用晶状体蛋白与葡萄糖保温合成晶状体蛋白AGE并免疫家兔获得抗血清，通过竞争性ELISA测定正常对照组与晚期肾炎组血清中AGE。

Methods Anti-serum was gained by immunizing rabbits with AGE-crystallin . The serum levels of AGE in normal and end-stage nephritis were measured by competitive ELISA .

晶状体蛋白βB1基因错义突变引起常染色体显性遗传性白内障

Missense mutation in the β B1-crystallin gene caused autosomal dominant congenital cataract in China

发现：热休克预处理组心肌细胞中αB晶状体蛋白表达明显增加，H2O2所致的细胞死亡率及LDH释放率降低，总抗氧化能力增强；

The results showed that heat shock pretreatment significantly reduced cell mortality rate , LDH release rate and increased total antioxidation of the cells .

结论αA2、βA3、γ晶状体蛋白和某些脱氢酶是最容易被糖基化的晶状体蛋白质。

Conclusion α A2 ,β A3 ,γ - crystallin and possibly some dehydrogenase are the most susceptible lens proteins to glycation .

其中，LECs的凋亡又是晶状体蛋白改变的发生因素之一。

And the apoptosis of LECs is also the cause of lens protein changes .

结果：①westernblot显示热休克后胞浆中可溶性αB晶状体蛋白迅速移位至细胞内的不溶性结构中，2h左右基本复位；

Results : ① Western blot analysis demonstrated that cytosolic soluble α B crystallin rapidly translocated to insoluble intracellular structure at 10 or 30 minutes and returned to cytosolic soluble compartment at about 1 ~ 2 ? h after heat shock .

重组人晶状体蛋白CRYAB基因表达载体的构建为研究CRYAB基因的功能及进一步研究先天性白内障的发病机制奠定了基础。

It is concluded that expression recombinant of α B-crystallin CRYAB gene will be helpful in studying function of CRYAB gene .

目的：研究半乳糖诱导白内障大鼠异常晶状体蛋白X36的出现及其与白内障形成的关系。

Objective : To study the abnormal crystalline protein X36 in cataract SD rat and to explore the relationship be-tween X36 and cataractogenesis .

结论α－晶状体蛋白具有分子伴娘功能。

Conclusion The α - crystalline has function of a molecular chaperone .

一个先天性核性白内障家族的γ晶状体蛋白基因筛查

Screening the γ - crystallin Genes in a Congenital Nuclear Cataract Family

糖基化对α-晶状体蛋白的修饰和分子伴侣活性的降低

Modification of α - crystallin and reduction of molecular chaperone activity by glycation

αB-晶状体蛋白在大鼠心肌缺血预适应早期相中的作用

The roles of α B-crystallin during early phase of myocardial ischemic preconditioning in rats

年龄和离体翻译后修饰对兔α-晶状体蛋白分子伴娘活性的影响

Effects of aging and post-translational modifications on molecular chaperone-like activity of α - crystalline

目的了解兔α－晶状体蛋白是否具有分子伴娘功能。

Objective To study whether α - crystalline has function of a molecular chaperone .

谷胱甘肽S-转移酶可能是外源性α晶状体蛋白的靶蛋白，但还需进一步的验证。

However , whether α crystallin exactly target on the glutathione S-transferase , needs further verification .

6-磷酸果糖和核糖对α-晶状体蛋白分子伴侣活性的作用

Effects of fructose 6 - phosphate and ribose on molecular chaperone activity of α - crystallin

研究年龄相关性白内障α-晶状体蛋白的分子伴侣功能。

Purpose : To evaluate the molecular chaperone function of α - crystallin in age-related cataract .

α晶状体蛋白的研究进展

Progression of alpha crystalline protein

αB-晶状体蛋白抗细胞凋亡的机制研究

The Mechanisms of α B-crystallin Against Apoptosis Induced by Hydrogen Peroxide in C_2C_ ( 12 ) Cells

热休克对心肌细胞中αB-晶状体蛋白移位及表达的影响

Effects of heat shock pretreatment on the translocation and expression of α B-crystallin in cultured neonatal rat cardiomyocytes

复方参果液对大鼠半乳糖性白内障及晶状体蛋白相关酶活性的影响

Effect of compound liquid of ginseng fruit on formation of rat galactose-cataract and activity of enzymes related to crystallin

对于大鼠晶状体蛋白的糖基化，其抑制率分别是对照组的：46%、30%、33%、31%和0。

For lens protein itwas 46 % , 305 , 33 % , 31 % respectively of 0 percent in control .

与对照组相比较，晶状体蛋白热凝聚值呈浓度依赖性增加（P<0·001）。

The aggregation of selenite-treated fractions showed a concentration-dependent increasing absorption compared with normal control portions ( P < 0.001 ) .

同白内障相关的晶状体蛋白基因突变发生在所有三个晶状体蛋白家族中（α-，β-和γ-晶状体蛋白），并显示为不同的表型。

Cataract-associated mutations in the crystallin genes are known to occur in all three crystallin families and show a variety of phenotypes .

遗传性核性金黄色结晶样白内障患者γ晶状体蛋白基因错义突变

Autosomal dominant congenital golden crystal nuclear cataract caused by a missense mutation in γ D crystallin gene ( CRYGD ) in a Chinese family