抗原肽

目的研究MAGE3抗原肽对肝细胞癌（HCC）患者进行免疫治疗的可行性。

Objective To explore the possibility of immune therapy for hepatocellular carcinoma ( HCC ) with MAGE-3 antigen peptide ( FLWGPRALV ) .

目的探讨通过树突状细胞（DC）提呈途径降低肿瘤抗原肽用量的可行性，了解热休克蛋白70（Hsp70）和抗原肽修饰DC作用的特点。

Objective To investigate the feasibility of reduction in tumor antigen peptide dose by dendritic cell ( DC ) presenting so as to elucidate the characteristics of modifying DC by heat shock protein ( Hsp70 ) and antigen peptide .

结论DC提呈抗原肽激活淋巴细胞的途径能够有效杀伤肿瘤。

Conclusions DC-presenting pathway to activate lymphocytes could kill the tumor effectively .

抗原肽、DC及CD4~+T细胞对CD8~+T细胞免疫应答的影响

Influence of Peptides , DCs and CD4 ~ + T Cells on CD8 ~ + T Cell Activation

目前在抗肿瘤免疫治疗中，最常用的负载DC的方式有应用抗原肽和全抗原两种。

DC vaccines are always made by been pulsed with tumor peptide or complex antigen in anti-tumor immunotherapy .

点突变p53抗原肽的预测及其与MHCⅠ类分子的结合

Prediction and binding of a mutant p53 peptide to MHC class I molecule

HBV抗原肽冲击的DC对慢性乙型肝炎及HBV携带者的免疫治疗作用

Efficacy of immunotherapy using autologous dendritic cells pulsed with hepatitis B surface antigen in patients with chronic hepatitis B

目的：可溶性HLAA2抗原肽复合物的体外折叠复性与生物素化。

AIM : To refold and biotinylate HLA A2 peptide complex in vitro .

胆管癌抗原肽对转染全长野生型p53的树突状细胞免疫功能的影响

Effects of bile duct cancer peptide on immune response of dendritic cells transfected with full-length wild type P53

SLAⅡ类基因的多态性和抗原肽结合位点密切相关，这些位点能结合处理过的抗原，然后递呈给T细胞。

SLA class ⅱ polymorphism was related to the antigenic peptide binding sites .

同种CTL识别表位的抗原肽非依赖性现象

Antigenic Peptide-independent Phenomena of the Epitope Recognized by Allogeneic CTL

MAGE-12的新B细胞表位抗原肽的设计、合成及免疫原性研究

Symthesis and identification of a new B-cell epitope of tumor antigen MAGE-12

MHCⅠ类分子及其结合抗原肽的研究进展

The Research Advances in MHC Class ⅰ Molecules and Their Binding Antigenic Peptides

抗原肽与MHC分子相互作用的QSAR模型研究

QSAR Model Study of Interaction between Peptides and MHC Molecules

结论同种反应性CTL对同种MHC分子的识别不依赖抗原肽。

Conclusion Allogeneic recognition of alloreactive CTLs to MHC molecules was antigenic peptide-independent .

GAD抗原肽抗体介导免疫耐受对NOD小鼠糖尿病治疗研究

GAD-grafted IgG Molecule Induces Immune Tolerance to Treat Diabetes in NOD Mice

目的检测安徽省1型糖尿病患者的抗原肽相关运载蛋白体（Transporterassociatedwithantigenprocessing，TAP）基因位点多态性。

Objective To understand the polymorphisms of transporter associated with antigen processing ( TAP ) genes in patients with Type 1 Diabetes mellitus in Anhui .

Mage-A3抗原肽负载DC过继免疫治疗乳腺癌的实验研究

Immunotherapy of dendritic cells loaded with the peptide derived from mage-a_3 on mice breast cancer

值得注意的是，疱疹病毒颗粒在宿主细胞内体中装配，而内体恰为MHcII分子与抗原肽结合的部位。

It is noteworthy that the Herpes virus assembles viral particles in endosomes , where antigenic peptides bind to MHC II molecules .

目的：体外折叠形成可溶性HLAG1抗原肽复合物，并研究其生物学功能。

AIM : To form soluble HLA-G 1-peptide complex by refolding in vitro , and study its immune function .

MHCI类分子与抗原肽的结合具有MHC等位基因特异性。

The combination between MHC class I molecule and antigenic peptide express the MHC allele - specificity .

Graves甲亢肝损害与抗原肽运载体1基因多态性关联性的研究

The Association between Graves ' Disease of Hepatic Injury and Polymorphism in Transporter Associated with Antigen Processing 1 Gene

HLA-A2相关肝癌抗原肽的初步研究

Study on HLA-A2 associated antigen peptide from human hepatocellular carcinoma

人食管癌Eca-109细胞Mr小于3000膜蛋白肿瘤抗原肽的筛选

Screening of tumor antigenic peptides in membrane antigen with M_r less than 3000 of human esophageal carcinoma Eca-109 cell line

目的探讨GAD抗原肽抗体诱导特异性免疫耐受对IDDM糖尿病的基因治疗。

Objective Gene therapy with GAD-IgG tolerogens that induces specific tolerance to IDDM .

微囊化CEA抗原肽表位/IL-18基因重组细胞疫苗的构建及其免疫学活性的研究

The Study on the Construction and the Immunological Activity of the Tumor Vaccine Combined with CEA-epitopes and IL-18 in Microencapsulated Cells

利用HLAI类分子与单链抗体的融合可将特定的抗原肽／HLA复合物加载到目的细胞表面，目前研究主要应用于加载HLA分子到肿瘤表面。

The fusion of HLA class I molecule and single-chain antibody can attach the peptide / HLA complex to target cells like tumor cells .

CTL和DC-抗原肽嵌合疫苗已应用于临床并取得了显著效果。

Now the application of CTL and " DC - peptide " vaccine in the clinic show much effect .

弱酸洗脱提取的肿瘤抗原肽致敏的树突状细胞对CTL的体内外激活效应

In vivo and in vitro activation of CTL by murine dendritic cells pulsed with acid eluted tumor antigen peptides

能与MHC分了绑定结合的抗原肽，被称为MHC分子亲和肽。MHC分子亲和肽的精确预测对于免疫学家和医学工作者意义重大。

Accurate prediction of such peptides that can bind to MHC molecules is of great significance for immunologists and biomedical staff .