肉豆蔻酸异丙酯
- 网络Isopropyl Myristate;ipm
肉豆蔻酸异丙酯
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渗透促进剂肉豆蔻酸异丙酯(IPM)加入到贴片中后,药物的脂溶性LogPc和其Kp间无抛物线关系。
When absorption promoter IPM ( isopropyl myristate ) was co administered with the drugs , the parabolic relationship no longer existed .
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结果表明,20%单月桂酸甘油酯、6%肉豆蔻酸异丙酯和10%油酸协同作用对其贴片有良好的促渗效果。
Results showed that the penetration effect of betamethasone patches could be improved obviously with the co-effect of 20 % mono-laurin , 6 % isopropyl myristate and 10 % oleic acid .
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结论:以1.0%卡波姆940,67%的乙醇和肉豆蔻酸异丙酯为基质的处方最佳。
Conclusion : 1 % of Carbomer 940,67 % of ethanol and isopropyl myristate were the optimum matrix of testosterone gel .
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30%乙醇和1%肉豆蔻酸异丙酯协同对α-细辛醚贴片的促渗效果最佳,透皮速率达到(20.67±1.33)μg。
30 % ethanol cooperates with 1 % Isopropyl Myristate ( IPM ) have the best effect on permeation of the patch .