耳毒性药物

避免使用耳毒性药物，除非持有合格卫生保健工作者开具的处方并对正确剂量有适当监测。

Avoiding the use of ototoxic drugs unless prescribed by a qualified health care worker and properly monitored for correct dosage ;

在任何年龄使用耳毒性药物，包括抗生素和抗疟药物，都可能损害内耳道。

The use of ototoxic drugs at any age , including some antibiotic and anti-malarial drugs , can damage the inner ear .

耳毒性药物致聋机理现状

Overview on Mechanism of Drug - induced Sensorineural Hearing Loss

庆大霉素是一种耳毒性药物，能够导致感音神经性聋。

Gentamycin is a kind of ototoxic drug , which can bring about hearing loss .

小鼠耳蜗螺旋器离体培养技术是一种较好的研究耳毒性药物的方法。

Technique of mice Cochlea Corti 's organ external cultivation is a better way to study ototoxicity drugs .

作者调查聋哑儿童229例，发现后天性聋哑儿童中54.2%与使用氨基甙类耳毒性药物有关。

An investigation and analysis of 229 deaf-mute children revealed that 54.2 % of acquired deafness were caused by ototoxic aminoglycoside drugs .

目的证实出生后第2周大鼠螺旋神经节神经元对耳毒性药物敏感。

Purpose To confirm that the cochlear spiral ganglion neurons are especially sensitive to the ototoxic drugs in the second week postnatal .

其他常见病因包括接触过量的噪音、头部和耳朵受伤、衰老和服用耳毒性药物。

Other common causes include exposure to excessive noise , head and ear injury , ageing and the use of ototoxic drugs .

耳毒性药物中毒性聋与氧自由基增多密切相关，且氧自由基参与了耳蜗组织损伤及耳蜗细胞凋亡的过程。

Hearing loss derived from ototoic drug was associated with oxygen free radical which make organ and cell of cochlea injuries or be death .

结论聋校学生听力损失以极度聋、重度聋为多，遗传因素及使用耳毒性药物是导致耳聋的重要原因。

Conclusion The hearing loss of deaf students is very serious , and genetic factor and ototoxic antibiotics were a principal causation in the occurrence of deafness .

普遍认为噪音，耳毒性药物，老化以及各种疾病引起的毛细胞的缺失，变性，损伤是感音神经性聋的主要原因。

The most common reason for sensorineural hearing loss is the degeneration of cochlear hair cells , resulting from noise overstimulation , ototoxic drugs , aging and other causes .

目的：耳蜗螺旋神经节细胞是听觉系统的初级神经元，了解它的基本电生理学特性及耳毒性药物的致病机理对于阐明听觉的形成机制和保护听觉功能意义重大。

Objective Spiral ganglion neuron is the primary neuron of auditory system , whose electrophysiological characteristics and mechanism of ototoxicity are important for clarifying the formation of audition and protecting auditory function .

毛细胞在体内、体外由于强声、耳毒性药物、老年化、外伤和各种疾病等造成的损伤，是感音神经性聋和平衡障碍的主要病理基础。

The trauma of hair cells caused by strong sound , drug , aging , injury and various diseases in vitro and in vivo is sensorineural deafness and equilibrium problems ' pathological base .

但在某些病理情况下，如：噪音、缺血、缺氧、感染、耳毒性药物使用等，均可以引起谷氨酸的蓄积，通过多种途径造成螺旋神经节细胞的损伤，导致不可逆的听力损伤。

Under certain pathological conditions , such as noise , ischemia , hypoxia , infection and ototoxic drugs , the over accumulated glutamate could cause swelling , even apoptosis of spiral ganglion neurons and result in irreversibly hearing loss .

周围性听路损害314耳（94.0%），致听力损害病因前4位依次为原因不明聋哑，原因不明聋，耳毒性药物，围产期脑损伤（103，98，42，40例）。

314 ears ( 94.0 % ) with peripheral hearing lesion , the top 4 etiological factors that induced to hearing lesion were unknown cause partimute , unknown cause deafness , ototoxicity drug and brain injury in perinatal stage ( 103 , 98 , 42 and 40 cases ) .

感音神经性聋是人类最常见的先天性疾患之一，也是耳科门诊最常见的疾患之一，由遗传、老化、耳毒性药物、感染及噪声等多因素共同作用而形成。

Sensorineural Hearing Loss is one of the most common human congenital diseases , and also one of the most common diseases in otology clinic . It is affected by many co-factors , including gene mutation , aging , and application of ototoxic drugs , infectious diseases and noise exposure .

氨基糖苷类抗生素的耳毒性是药物在内耳淋巴液内积聚，损害了毛细胞的功能所致。

The ototoxicity of aminoglycoside antibiotics was due to the accumulation of drugs in the inner ear fluid and preventing the function of hair cells .