多能造血干细胞

多能造血干细胞的不均一性Ⅲ.9天和13天CFU-S与脑相关表面抗原

The heterogeneity of pluripotent hematopoietic stem cell ⅲ . the brain-associated surface antigen of day 9 and day 13 cfu-s ⅲ

研究背景慢性髄细胞白血病（CML）是一种起源于多能造血干细胞的克隆性恶性血液病。

【 Research background 】 Chronic myeloid leukemia ( CML ) is a clonal hematologic malignancy that arise in the stem cell compartment .

用脾集落技术结合有关方法对小鼠多能造血干细胞（CFU-S）的一些性质与功能做了观察。

The properties and functions of mouse pluripotential stem cells ( CFU-S ) were studied with spleen colony technique and other related methods .

慢性粒细胞白血病（Chronicmyeloidleukemia，CML）是一种骨髓多能造血干细胞异常增生的血液系统恶性肿瘤，占成人白血病的20%，目前尚无有效的治疗方法。

Chronic myeloid leukemia ( CML ) is a malignant disease of human hematopoietic stem cell , accounting for 20 % of leukemias in adult . So far there is no effective treatment to put the majority of CML patients under control .

发现无细胞胎肝液能明显促进受抑制骨髓中多能造血干细胞（CFUS）的集落形成率，但对扩散盒内粒系祖细胞（CFUD）的增殖分化无促进作用。

It was discovered that FLL could significantly promote the rate productive of colony of CFU-S in the depressed marrow , but could not stimulate the proliferation and differentiation of CFU-D in the diffussion chamber .

采用体外细胞培养的方法，观察了小鼠腹腔巨噬细胞对骨髓多能造血干细胞（CFU-S）和粒-单系祖细胞（CFU-GM）增殖的调控作用。

By using the techniques of spleen colony formation and culture of hematopoietic progenitor cells in vitro , we studied the actions of peritoneal macrophages of the mouse on the proliferation of colony forming unit-spleen ( CFU-S ) and colony forming unit - granulocyte monocyte ( CFU-GM ) .

肥大细胞是由骨髓的多能造血干细胞分化而来。

Mast cells are derived from pluripotent progenitor stem cells in the bone marrow .

造血是人一生中不断由多能造血干细胞更新造血祖细胞和成熟血细胞的过程。

Hematopoiesis is a lifelong process responsible for replenishing hematopoietic progenitor cells and mature blood cells from a pool of pluripotent , long-term reconstituting stem cells .

哺乳类红细胞的发生是多能造血干细胞在诸多细胞因子协同作用下沿着一定的基因表达程序进行增殖和分化的过程。

Mammalian erythropoiesis is a process of proliferation of progenitor or multipotential stem cells towards differentiation along a prospective sequential gene expression program under the coordination of activation or suppression of a series of cytokines .

人的造血分化是一个极复杂且多步骤的发展过程，它起始于多能造血干细胞（HSCs）在骨髓微环境（HSCsniche）中的产生，以红细胞生成为终止。

Human hematopoiesis is a very complex and multistep developmental process that starts from the level of pluripotent hematopoietic stem cells ( HSCs ) at bone marrow microenvironment ( HSCs niche ) and terminates with the production of erythrocytes .